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  • 00:00

    Hello! I am Dr Aizaz from medicovisual.com and  today we will talk about development of placenta.  

  • 00:07

    So, what is placenta? What is the definition  of placenta? Placenta is a discoidal  

  • 00:15

    temporary but vital vascular feto-maternal  organ that is responsible for metabolism and  

  • 00:23

    exchange of chemicals between mother and fetus  or the embryo. Please note that I will use the  

  • 00:32

    term embryo and fetus interchangeably during  this lecture but truly speaking the fetus is  

  • 00:38

    an embryo that has grown beyond the ninth  week of development after fertilization.  

  • 00:45

    If you want to learn more about such embryological  terms please watch the first lecture of embryology  

  • 00:51

    lecture series by medico- visual. Now  that we have seen that what is placenta  

  • 00:59

    let's first look at why there is the  need of placenta for the human embryo?  

  • 01:07

    As you know that birds lay their eggs outside  their bodies their eggs contains nutritious  

  • 01:14

    egg yolk the embryos of the bird develop  inside these eggs while utilizing the egg  

  • 01:23

    yolk. They utilize this egg yolk they eat up this  egg yolk and develop inside the egg. This type of  

  • 01:30

    development comes with a caveat that such eggs are  vulnerable to harshness of external environment.  

  • 01:38

    For example these eggs they may be destroyed by  other animals, they may even be eaten up by humans  

  • 01:45

    Hmm! the chick eggs are yummy I must say.  The human mothers are much protective  

  • 01:52

    regarding their embryos. The human embryo grows  inside the womb of his or her mother. Warm,  

  • 02:00

    nourished and well protected from the external  environment, inside the bodies of their mothers.  

  • 02:07

    So, as the human embryo develop inside the body of  their mother they contain little to no egg yolk.  

  • 02:15

    It means that they somehow need to  fetch the nutrition from their mother.  

  • 02:20

    Also they have to release the waste material  into the maternal body and for this purpose  

  • 02:26

    human and other mammals have evolved a special  nutritious fetching device called placenta.  

  • 02:34

    So, here is this plate-like device called  placenta, plate-like organ called placenta with  

  • 02:40

    the help of which the, the fetus or the embryo  will fetch the nutrition from the maternal body  

  • 02:47

    and release its waste materials into the maternal  blood. So, this is the purpose of placenta.  

  • 02:57

    Now let's see when does placenta start developing?  Placenta start developing much earlier than you  

  • 03:04

    think. So, as you know that a zygote, the  fertilized egg called zygote it undergoes  

  • 03:12

    a series of mitotic division called cleavage  to form a ball of cell called morula.  

  • 03:19

    Morula consists of closely packed cells  called blastomeres. They are tightly,  

  • 03:26

    closely packed with each other. At this morula  stage these blastomeres they decide so as to say  

  • 03:33

    that these outer cells they will for, they will  arrange for the nutrition and these inner cells  

  • 03:39

    they will form the embryo proper. So, as this  morula comes inside the uterine cavity, here this  

  • 03:48

    zona pelucida will rupture and a cavity will form  inside this and now two types of cells are formed  

  • 03:59

    these cells that will form the embryo  proper they are called inner cell mass or  

  • 04:04

    embryoblast and the other cells these cells  that are outside this embryo proper they are  

  • 04:11

    called outer cell mass or trophoblast. These  trophoblasts they are the major contribution,  

  • 04:18

    they forms the major part of the fetal placenta.  Actually the placenta it has two parts the fetal  

  • 04:26

    part as well as maternal part and we will  discuss these details later. So, now this  

  • 04:35

    inner cell mass and outer cell mass it has to  implant into the endometrium of their mother.  

  • 04:44

    Let's zoom in into this part and let's see what  happens. So, here is the endometrium of maternal  

  • 04:51

    uterus and here comes this embryo through selectin  it will loosely bind with the uterine wall  

  • 05:00

    as it happens these cells of the uterus they  will undergo what we call as decidual reaction.  

  • 05:08

    By decidual reaction I mean  that they will accumulate  

  • 05:12

    lots of glycogen and fat and they will  become fat globular cells and we call them  

  • 05:18

    decidual cells and this process of formation of  decidual cells is called decidual reaction. As  

  • 05:26

    this decidual reaction happens this  outermost layer of the endometrium,  

  • 05:31

    this luminal layer of the endometrium is now  called decidua of endometrium of maternal uterus.  

  • 05:40

    After loosely binding through the selectin  molecules now this embryo will firmly bind  

  • 05:46

    with the help of fibronectin and integrins. Then  what happens that some of these trophoblast cells  

  • 05:53

    at this part they will proliferate and they will  lose their cell membranes and they will act as  

  • 05:59

    a single structure called syncytium. Now the  trophoblast has been divided into cytotrophoblast  

  • 06:07

    that has clear-cut cellular boundaries and  syncytiotrophoblast that does not have clear-cut  

  • 06:13

    cell boundaries. The syncytiotrophoblast is highly  invasive and it will invade the uterine wall.  

  • 06:21

    Development up to this happens till  the end of first week of development.  

  • 06:26

    Now let's go to the mid of second  week of development and let's see  

  • 06:30

    what happens to trophoblasts during  the mid of second week of development.  

  • 06:38

    So, now we have fast forwarded towards the mid  of second week of development. Here you can  

  • 06:43

    see that this is the syncytiotrophoblast  and here is the cytotrophoblast. These  

  • 06:49

    are the two parts of trophoblast. Within the  syncytiotrophoblast small but interconnected  

  • 06:56

    network of spaces called lacunar network is  formed. As the syncytiotrophoblast erodes the  

  • 07:04

    maternal endometrium it also erodes the maternal  blood vessels. Let's say it has eroded at one end  

  • 07:12

    a maternal artery or arteriole and at the other  end it has eroded the maternal venule. Actually  

  • 07:20

    multiple arterioles and venules are eroded but for  the sake of simplicity I have only shown the one.  

  • 07:28

    So, with such erosions the arterial blood with  high pressure they start flowing into the lacunar  

  • 07:35

    network and then this blood goes back into the  venule. So, as the maternal blood start flowing  

  • 07:42

    into this lacunar network this is the formation of  earliest form of the placenta and this is called  

  • 07:51

    primitive uteroplacental circulation. Now if we  unblur the embryonic part what we will see is that  

  • 07:59

    this is the embryo proper and it consists  of amniotic cavity and yolk sac cavity  

  • 08:04

    and all this structure is surrounded by chorionic  cavity it is also called extra embryonic coelom.  

  • 08:12

    And here is the extra embryonic somatopleuric  mesoderm. Remember that chorion consists of  

  • 08:19

    extra embryonic somatopleuric mesoderm as well  as the cytotrophoblast and according to some  

  • 08:26

    authors the syncytiotrophoblast also contributes  towards the chorionic membrane or chorion.  

  • 08:33

    Now what happens here is that as the nutritious  blood comes into the lacunae here the nutrients  

  • 08:40

    including oxygen and glucose they can diffuse into  the chorionic cavity and from chorionic cavity  

  • 08:47

    nutrition can be picked up by yolk sac as well as  the amniotic cavity and then this nutrition can  

  • 08:55

    reach to these cells that are forming the  bilaminar embryonic disc or bilaminar germ disc.  

  • 09:02

    Similarly the waste material at the stage it  is secreted by the cells into first yolk sac  

  • 09:09

    as well as amniotic cavity and then these are  released into the chorionic cavity and from  

  • 09:15

    chorionic cavity they go back to the maternal  blood and this maternal blood it will be then  

  • 09:21

    released into the venules of the mother. So,  at this stage there are no blood vessels here  

  • 09:28

    simple diffusion is enough to meet  the nutritious needs of the baby.  

  • 09:35

    At the end of second week of development the  embryo is completely implanted into the decidua  

  • 09:41

    of endometrium of their mother. Topographically  we can divide the decidua into three types  

  • 09:49

    this capsule-like deciduous that is overlying the  implanted conceptus is called deciduous capsularis  

  • 10:00

    and this basal plate-like deciduous that  is underlying the conceptus is called  

  • 10:06

    decidua basalis and all the remaining part  of decidua all this part of the decidua  

  • 10:14

    which is not involved in this process  it is named as decidua parietalis.  

  • 10:20

    So, we have three types of decidua. Please  note that decidua basalis is the only part  

  • 10:26

    of decidua that contributes towards the  formation of maternal part of placenta.  

  • 10:35

    So, now let's see further development of  placenta. So, here we are near the end of  

  • 10:40

    second week of development at this stage  the finger like processes primary villi  

  • 10:46

    arise from the cytotrophoblast and they  penetrate into the syncytiotrophoblast.  

  • 10:53

    Let's zoom into the one primary villi and let's  see what further happens to this primary villi.  

  • 11:01

    So, here is a single primary villi.  It consists of finger-like projection  

  • 11:06

    of cytotrophoblast along with that here is  the extra embryonic somatopleuric mesoderm.  

  • 11:14

    So, here is another 3D diagram of  cut section of this primary villi.  

  • 11:22

    During the third week of development the  underlying extra embryonic somatopleuric mesoderm  

  • 11:28

    sends its extension into the core of this primary  villus and as this mesenchymal core is formed  

  • 11:36

    inside the primary villus. Now this primary  villus is converted to the secondary villus.  

  • 11:42

    So, again in this 3D diagram you can see that  there is the inner core in a mesenchymal core  

  • 11:48

    which is the extension of extra  embryonic somatopleuric mesoderm.  

  • 11:54

    This mesenchyme then forms the blood vessels  inside it and as the blood vessels form inside  

  • 12:01

    this Villi. Now it is termed as tertiary villus.  The blood vessels has an arteriolar end as well  

  • 12:09

    as the venous end. Interestingly the arterial  end here it is shown in blue colour because it  

  • 12:16

    is oxygen deficient and the venous end is shown in  red colour because it is oxygen rich because the  

  • 12:24

    nutrient from the maternal blood comes inside it  and it becomes oxygen rich. Usually the tertiary  

  • 12:31

    villi are branched but the structure of each of  its branch is similar to the main stem villus.  

  • 12:39

    So, here is a trophoblast with that  number of branched tertiary villi.  

  • 12:44

    Initially the chorionic villi surrounds the  embryo from all sides but later on perhaps due to  

  • 12:51

    decreased blood supply at the luminal side these  villi, this chorionic villi here they degenerate  

  • 12:58

    and the chorionic villi are mainly present on that  side of trophoblast that is facing the endometrium  

  • 13:04

    of mother. So, this part of chorion or this part  of trophoblast it has lots of villi and it is  

  • 13:13

    rough in structure it is leaf-like in structure  we call it chorionic frondosum but this side,  

  • 13:20

    this luminal side of trophoblast or chorion it  has little to no chorionic villi. So, it has a  

  • 13:26

    smooth structure and we call it chorionic laeve.  So, there are two faces of chorion the chorionic  

  • 13:33

    frondosum and chorionic laeve. Please note that  only the chorionic frondosum contributes towards  

  • 13:40

    the fetal part of placenta. So, here are the  maternal endometrial spiral arteries that open up  

  • 13:48

    into these lacunae and then within this  lacunae the exchange of material occurs  

  • 13:53

    and then this blood is taken up by the endometrial  veins back into the maternal circulatory system.  

  • 14:03

    So, here you can see that within the extra  embryonic somatopleuric mesoderm these chorionic  

  • 14:08

    vessels develop and these chorionic vessels  they are connected with the vasculature of  

  • 14:14

    the tertiary villi. At the end of third week of  development the primordial heart is also formed  

  • 14:21

    and primordial blood vessels also begin to form  within the embryo as well as in the wall of yolk  

  • 14:28

    sac and this wall is formed by the extra embryonic  splanchnopleuric mesoderm. This primordial heart  

  • 14:35

    it starts pumping the blood. Now as the embryo  has grown enough the simple diffusion from this  

  • 14:42

    lacunae into these cavities is simply not enough  to meet the nutritious needs of the baby. So, this  

  • 14:50

    circulatory system is required to help in exchange  of material. So, now you can see that blood  

  • 14:56

    vessels are found within the embryo and blood  vessels are formed within this primordial placenta  

  • 15:02

    but still there is no connection between these  blood vessels. So, how the connection will be  

  • 15:08

    established? Well! the answer is simple we have  this connecting stalk. The blood vessels also  

  • 15:15

    form within the connecting stalk and these are  called the umbilical vessels. This connecting  

  • 15:20

    stalk is the primordial of umbilical cord.  Now let's see how umbilical cord forms.  

  • 15:29

    First of all you know that an extension of yolk  sac into the connecting stalk called allantois  

  • 15:35

    forms. Now as the embryo undergoes the embryonic  folding, this will be the structure of conceptus  

  • 15:45

    a part of yolk sac is incorporated into the embryo  and the remaining part of yolk sac is outside the  

  • 15:53

    embryo but both of these part they are connected  by this duct by this connection called vitelline  

  • 15:59

    duct or omphaloenteric duct. As the embryo grow  further this yolk sac is markedly diminished.  

  • 16:08

    Now the whole this structure, this  vitelline duct, this allantois  

  • 16:12

    and the connecting stalk along with these  blood vessels it forms what we call as  

  • 16:19

    primitive umbilical cord later due to some unknown  reason the amniotic cavity markedly grows in size  

  • 16:30

    as it happens it completely surrounds and  protects this umbilical cord from all sides.  

  • 16:37

    As it happens the chorionic cavity is obliterated.  Now there is no more chorionic cavity and this  

  • 16:44

    amnion it is connected with chorion and these  two layers they are called Amniochorion. So, as  

  • 16:51

    you know that this embryo along with these extra  embryonic membranes and this primitive placenta  

  • 16:58

    it is implanted into the decidua of his or  her mother and here is the decidua capsularis  

  • 17:05

    and here is the deciduous basalis and rest  of the decidua is the decidua parietalis,  

  • 17:13

    as the embryo grows further the uterine cavity is  obliterated and here you can see that this decidua  

  • 17:20

    capsularis it starts touching the deciduous  parietalis. As the embryo grows further the blood  

  • 17:28

    supply of decidua capsularis is also compromised  this results in degeneration of decidua  

  • 17:35

    capsularis. Ultimately the decidua capsularis is  also lost. This degeneration of decidua capsularis  

  • 17:43

    happens somewhere between 5th and sixth month of  development. So, what we can say is that initially  

  • 17:50

    the embryo starts growing within the decidua but  later on it is growing within the uterine cavity.  

  • 17:57

    Remember that initially the embryo is not growing  within the uterine cavity initially it is growing  

  • 18:04

    within the uterus but later on as the decidua  capsularis is lost now it is growing within  

  • 18:10

    the uterine cavity and it is growing so much  so that uterine cavity is even obliterated.  

  • 18:16

    Thank you so much for watching this video. In the  next lecture we will see the structure of placenta  

  • 18:22

    in a bit more detail we will also learn more about  the physiology and functioning of the placenta.

All

The example sentences of PRIMARY in videos (15 in total of 1385)

let verb, base form 's possessive ending zoom noun, singular or mass into preposition or subordinating conjunction the determiner one cardinal number primary adjective villi noun, singular or mass and coordinating conjunction let verb, base form 's possessive ending see verb, base form what wh-pronoun further adjective happens verb, 3rd person singular present to to this determiner primary adjective villi noun, singular or mass .
they personal pronoun may modal end verb, base form up preposition or subordinating conjunction being verb, gerund or present participle the determiner primary adjective wage noun, singular or mass earner noun, singular or mass , the determiner primary adjective parent noun, singular or mass , the determiner one cardinal number who wh-pronoun functions verb, 3rd person singular present
your possessive pronoun primary adjective goal noun, singular or mass come verb, base form from preposition or subordinating conjunction many adjective successful adjective people noun, plural discover verb, non-3rd person singular present their possessive pronoun primary adjective goals noun, plural by preposition or subordinating conjunction analyzing verb, gerund or present participle smaller adjective, comparative
now adverb remember verb, base form , primary adjective benzylic adjective , even adverb though preposition or subordinating conjunction it personal pronoun 's verb, 3rd person singular present primary adjective is verb, 3rd person singular present still adverb a determiner lot noun, singular or mass more adverb, comparative stable adjective than preposition or subordinating conjunction
now adverb select verb, base form your possessive pronoun primary proper noun, singular dns proper noun, singular server proper noun, singular and coordinating conjunction enter verb, base form the determiner primary adjective dns proper noun, singular server noun, singular or mass from preposition or subordinating conjunction the determiner following verb, gerund or present participle
what wh-pronoun we personal pronoun will modal do verb, base form that wh-determiner create verb, base form primary adjective partition verb, base form you personal pronoun have verb, non-3rd person singular present to to type verb, base form " create verb, base form primary adjective partition noun, singular or mass "
primary adjective so preposition or subordinating conjunction it personal pronoun can modal follow verb, base form and coordinating conjunction then adverb it personal pronoun starts noun, plural to to go verb, base form towards preposition or subordinating conjunction the determiner native adjective primary adjective
so preposition or subordinating conjunction they personal pronoun 're verb, non-3rd person singular present not adverb quite adverb it personal pronoun 's verb, 3rd person singular present their possessive pronoun primary adjective job noun, singular or mass for preposition or subordinating conjunction us personal pronoun but coordinating conjunction it personal pronoun 's verb, 3rd person singular present not adverb their possessive pronoun primary adjective
pick verb, base form that preposition or subordinating conjunction as preposition or subordinating conjunction your possessive pronoun primary adjective goal noun, singular or mass , the determiner primary adjective direction noun, singular or mass you personal pronoun re noun, singular or mass going verb, gerund or present participle to to go verb, base form and coordinating conjunction then adverb you personal pronoun ve proper noun, singular
expedite verb, base form only adjective works noun, plural for preposition or subordinating conjunction the determiner primary adjective , you personal pronoun pay verb, non-3rd person singular present the determiner premium noun, singular or mass processing noun, singular or mass fee noun, singular or mass from preposition or subordinating conjunction the determiner primary adjective applicant noun, singular or mass ,
into preposition or subordinating conjunction the determiner primary adjective suites noun, plural primary adjective bathroom noun, singular or mass and coordinating conjunction closet noun, singular or mass got verb, past tense some determiner storage noun, singular or mass spaces noun, plural over preposition or subordinating conjunction there adverb on preposition or subordinating conjunction my possessive pronoun
you personal pronoun and coordinating conjunction that wh-determiner is verb, 3rd person singular present going verb, gerund or present participle to to be verb, base form the determiner primary adjective bedroom noun, singular or mass the determiner primary adjective bathroom noun, singular or mass closets noun, plural and coordinating conjunction laundry noun, singular or mass space noun, singular or mass
the determiner property noun, singular or mass this determiner is verb, 3rd person singular present the determiner primary adjective and coordinating conjunction this determiner primary adjective suite noun, singular or mass is verb, 3rd person singular present incredible adjective for preposition or subordinating conjunction so adverb many adjective different adjective reasons noun, plural
fashion proper noun, singular is verb, 3rd person singular present not adverb the determiner primary adjective thing noun, singular or mass , the determiner primary adjective effort noun, singular or mass in preposition or subordinating conjunction motion noun, singular or mass pictures noun, plural is verb, 3rd person singular present to to tell verb, base form a determiner story noun, singular or mass
primary proper noun, singular sources noun, plural let verb, non-3rd person singular present you personal pronoun examine verb, non-3rd person singular present the determiner thing noun, singular or mass , secondary adjective sources noun, plural let verb, non-3rd person singular present you personal pronoun examine verb, non-3rd person singular present the determiner primary adjective sources noun, plural .

Use "primary" in a sentence | "primary" example sentences

How to use "primary" in a sentence?

  • There are so many young talented actors today whose work I respect and admire - Ryan Gosling is probably primary among them. I take inspiration from so many amazing actors.
    -Daniel Sunjata-
  • Being is primary and doing is secondary for them. Celebration comes first and work takes a back seat in their lives. Work is preparatory to celebration.
    -Rajneesh-
  • The primary motive for good care and good use of the land-community is always going to be affection, which is too often lacking.
    -Wendell Berry-
  • There are other relations besides reality, which the mind is capable of grasping and which also are primary, like chance, illusion, the fantastic, the dream.
    -Louis Aragon-
  • That's a wonderful thing, because one of the primary qualities of a good performance is honesty.
    -Roberta Flack-
  • The primary rule of business success is loyalty to your employer. That's all right as a theory. What is the matter with loyalty to yourself?
    -Mark Twain-
  • If you want small changes in your life, work on your attitude. But if you want big and primary changes, work on your paradigm.
    -Stephen Covey-
  • I hope to see Ruby help every programmer in the world to be productive, and to enjoy programming, and to be happy. That is the primary purpose of Ruby language.
    -Yukihiro Matsumoto-

Definition and meaning of PRIMARY

What does "primary mean?"

/ˈprīˌmerē/

adjective
principal.
noun
preliminary election.
verb
run as opponent of incumbent in preliminary election.

What are synonyms of "primary"?
Some common synonyms of "primary" are:
  • main,
  • chief,
  • key,
  • prime,
  • central,
  • principal,
  • foremost,
  • first,
  • predominant,
  • paramount,
  • overriding,
  • major,
  • ruling,
  • dominant,

You can find detailed definitions of them on this page.

What are antonyms of "primary"?
Some common antonyms of "primary" are:
  • secondary,
  • subordinate,
  • secondary,

You can find detailed definitions of them on this page.