Granulation is the act or process of forming or crystallizing into grains. Granules typically
Granulation is the act or process of forming or crystallizing into grains. Granules typically

have a size range between 0.2 to 4.0 mm depending on their subsequent use.
have a size range between 0.2 to 4.0 mm depending on their subsequent use.

Synonym "Agglomeration": Agglomeration processes or in a more general term particle size enlargement
Synonym "Agglomeration": Agglomeration processes or in a more general term particle size enlargement

technologies are great tools to modify product properties. Agglomeration of powders is widely
technologies are great tools to modify product properties. Agglomeration of powders is widely

used to improve physical properties like: wettability, flowability, bulk density and
used to improve physical properties like: wettability, flowability, bulk density and

product appearance.
product appearance.

Chemical industry
Chemical industry

In the chemical industry, granulation refers to the act or process in which large objects
In the chemical industry, granulation refers to the act or process in which large objects

are cut or shredded and remelted into granules or pellets.
are cut or shredded and remelted into granules or pellets.

Pharmaceutical industry In the pharmaceutical industry, granulation
Pharmaceutical industry In the pharmaceutical industry, granulation

refers to the act or process in which primary powder particles are made to adhere to form
refers to the act or process in which primary powder particles are made to adhere to form

larger, multiparticle entities called granules. It is the process of collecting particles
larger, multiparticle entities called granules. It is the process of collecting particles

together by creating bonds between them. Bonds are formed by compression or by using a binding
together by creating bonds between them. Bonds are formed by compression or by using a binding

agent. Granulation is extensively used in the manufacturing of tablets and pellets.
agent. Granulation is extensively used in the manufacturing of tablets and pellets.

The granulation process combines one or more powder particles and forms a granule that
The granulation process combines one or more powder particles and forms a granule that

will allow tableting or spheronization process to be within required limits. This way predictable
will allow tableting or spheronization process to be within required limits. This way predictable

and repeatable process is possible and quality tablets or pellets can be produced using tabletting
and repeatable process is possible and quality tablets or pellets can be produced using tabletting

or spheronization equipment. Purpose
or spheronization equipment. Purpose

Granulation is carried out for various reasons, one of those is to prevent the segregation
Granulation is carried out for various reasons, one of those is to prevent the segregation

of the constituents of powder mix. Segregation is due to differences in the size or density
of the constituents of powder mix. Segregation is due to differences in the size or density

of the component of the mix. Normally, the smaller and/or denser particles tend to concentrate
of the component of the mix. Normally, the smaller and/or denser particles tend to concentrate

at the base of the container with the larger and/or less dense ones on the top. An ideal
at the base of the container with the larger and/or less dense ones on the top. An ideal

granulation will contain all the constituents of the mix in the correct proportion in each
granulation will contain all the constituents of the mix in the correct proportion in each

granule and segregation of granules will not occur.
granule and segregation of granules will not occur.

Many powders, because of their small size, irregular shape or surface characteristics,
Many powders, because of their small size, irregular shape or surface characteristics,

are cohesive and do not flow well. Granules produced from such a cohesive system will
are cohesive and do not flow well. Granules produced from such a cohesive system will

be larger and more isodiametric, both factors contributing to improved flow properties.
be larger and more isodiametric, both factors contributing to improved flow properties.

Some powders are difficult to compact even if a readily compactable adhesive is included
Some powders are difficult to compact even if a readily compactable adhesive is included

in the mix, but granules of the same powders are often more easily compacted. This is associated
in the mix, but granules of the same powders are often more easily compacted. This is associated

with the distribution of the adhesive within the granule and is a function of the method
with the distribution of the adhesive within the granule and is a function of the method

employed to produce the granule. For example, if one were to make tablets from
employed to produce the granule. For example, if one were to make tablets from

granulated sugar versus powdered sugar, powdered sugar would be difficult to compress into
granulated sugar versus powdered sugar, powdered sugar would be difficult to compress into

a tablet and granulated sugar would be easy to compress. Powdered sugar’s small particles
a tablet and granulated sugar would be easy to compress. Powdered sugar’s small particles

have poor flow and compression characteristics. These small particles would have to be compressed
have poor flow and compression characteristics. These small particles would have to be compressed

very slowly for a long period of time to make a worthwhile tablet. Unless the powdered sugar
very slowly for a long period of time to make a worthwhile tablet. Unless the powdered sugar

is granulated, it could not efficiently be made into a tablet that has good tablet characteristics
is granulated, it could not efficiently be made into a tablet that has good tablet characteristics

such as uniform content or consistent hardness. Granulation techniques
such as uniform content or consistent hardness. Granulation techniques

In pharmaceutical industry, two types of granulation technologies are employed, namely, wet granulation
In pharmaceutical industry, two types of granulation technologies are employed, namely, wet granulation

and dry granulation. Wet granulation
and dry granulation. Wet granulation

In wet granulation, granules are formed by the addition of a granulation liquid onto
In wet granulation, granules are formed by the addition of a granulation liquid onto

a powder bed which is under the influence of an impeller or air. The agitation resulting
a powder bed which is under the influence of an impeller or air. The agitation resulting

in the system along with the wetting of the components within the formulation results
in the system along with the wetting of the components within the formulation results

in the aggregation of the primary powder particles to produce wet granules. The granulation liquid
in the aggregation of the primary powder particles to produce wet granules. The granulation liquid

contains a solvent which must be volatile so that it can be removed by drying, and be
contains a solvent which must be volatile so that it can be removed by drying, and be

non-toxic. Typical liquids include water, ethanol and isopropanol either alone or in
non-toxic. Typical liquids include water, ethanol and isopropanol either alone or in

combination. The liquid solution can be either aqueous based or solvent based. Aqueous solutions
combination. The liquid solution can be either aqueous based or solvent based. Aqueous solutions

have the advantage of being safer to deal with than solvents.
have the advantage of being safer to deal with than solvents.

Water mixed into the powders can form bonds between powder particles that are strong enough
Water mixed into the powders can form bonds between powder particles that are strong enough

to lock them together. However, once the water dries, the powders may fall apart. Therefore,
to lock them together. However, once the water dries, the powders may fall apart. Therefore,

water may not be strong enough to create and hold a bond. In such instances, a liquid solution
water may not be strong enough to create and hold a bond. In such instances, a liquid solution

that includes a binder is required. Povidone, which is a polyvinyl pyrrolidone, is one of
that includes a binder is required. Povidone, which is a polyvinyl pyrrolidone, is one of

the most commonly used pharmaceutical binders. PVP is dissolved in water or solvent and added
the most commonly used pharmaceutical binders. PVP is dissolved in water or solvent and added

to the process. When PVP and a solvent/water are mixed with powders, PVP forms a bond with
to the process. When PVP and a solvent/water are mixed with powders, PVP forms a bond with

the powders during the process, and the solvent/water evaporates. Once the solvent/water has been
the powders during the process, and the solvent/water evaporates. Once the solvent/water has been

dried and the powders have formed a more densely held mass, then the granulation is milled.
dried and the powders have formed a more densely held mass, then the granulation is milled.

This process results in the formation of granules. The process can be very simple or very complex
This process results in the formation of granules. The process can be very simple or very complex

depending on the characteristics of the powders, the final objective of tablet making, and
depending on the characteristics of the powders, the final objective of tablet making, and

the equipment that is available. In the traditional wet granulation method the wet mass is forced
the equipment that is available. In the traditional wet granulation method the wet mass is forced

through a sieve to produce wet granules which is subsequently dried.
through a sieve to produce wet granules which is subsequently dried.

Dry granulation The dry granulation process is used to form
Dry granulation The dry granulation process is used to form

granules without using a liquid solution because the product granulated may be sensitive to
granules without using a liquid solution because the product granulated may be sensitive to

moisture and heat. Forming granules without moisture requires compacting and densifying
moisture and heat. Forming granules without moisture requires compacting and densifying

the powders. In this process the primary powder particles are aggregated under high pressure.
the powders. In this process the primary powder particles are aggregated under high pressure.

Sweying granulator or high shear mixer-granulator can be used for the dry granulation.
Sweying granulator or high shear mixer-granulator can be used for the dry granulation.

Dry granulation can be conducted under two processes; either a large tablet is produced
Dry granulation can be conducted under two processes; either a large tablet is produced

in a heavy duty tabletting press or the powder is squeezed between two counter-rotating rollers
in a heavy duty tabletting press or the powder is squeezed between two counter-rotating rollers

to produce a continuous sheet or ribbon of materials.
to produce a continuous sheet or ribbon of materials.

When a tablet press is used for dry granulation, the powders may not possess enough natural
When a tablet press is used for dry granulation, the powders may not possess enough natural

flow to feed the product uniformly into the die cavity, resulting in varying degrees of
flow to feed the product uniformly into the die cavity, resulting in varying degrees of

densification. The roller compactor uses an auger-feed system that will consistently deliver
densification. The roller compactor uses an auger-feed system that will consistently deliver

powder uniformly between two pressure rollers. The powders are compacted into a ribbon or
powder uniformly between two pressure rollers. The powders are compacted into a ribbon or

small pellets between these rollers and milled through a low-shear mill. When the product
small pellets between these rollers and milled through a low-shear mill. When the product

is compacted properly, then it can be passed through a mill and final blend before tablet
is compacted properly, then it can be passed through a mill and final blend before tablet

compression. See also
compression. See also

Granular material Pelletizing
Granular material Pelletizing

Spheronisation
Spheronisation

References
References

Handbook of Pharmaceutical Granulation- 3rd Edition Editor- Dilip M. Parikh
Handbook of Pharmaceutical Granulation- 3rd Edition Editor- Dilip M. Parikh

Pharmaceutics - The science of dosage form design - M. E. Aulton 2nd EDT
Pharmaceutics - The science of dosage form design - M. E. Aulton 2nd EDT

Pharmaceutical dosage forms and drug delivery system - Loyd V. Allen, Nicholas G. Popovich
Pharmaceutical dosage forms and drug delivery system - Loyd V. Allen, Nicholas G. Popovich

& Howard C. Ansel 8th EDT Lachman leon, Industrial pharmacy, special
& Howard C. Ansel 8th EDT Lachman leon, Industrial pharmacy, special

indian edition, CBS publishers External links
indian edition, CBS publishers External links

Nanoparticle technology handbook Hosokawa Corporation
Nanoparticle technology handbook Hosokawa Corporation

5th International Granulation Workshop
5th International Granulation Workshop