Ugh, your head hurts,
Ugh, your head hurts,

you're nauseated, you're achy,
you're nauseated, you're achy,

and you are certainly never drinking again.
and you are certainly never drinking again.

The only thought running through your foggy mind is,
The only thought running through your foggy mind is,

"Why are hangovers the absolute worst?"
"Why are hangovers the absolute worst?"

Let's go back to last night.
Let's go back to last night.

As you down that cocktail, alcohol migrates
As you down that cocktail, alcohol migrates

through your GI tract to your liver,
through your GI tract to your liver,

where enzymes break it down.
where enzymes break it down.

But as you continue to drink, your liver can't keep up.
But as you continue to drink, your liver can't keep up.

So the alcohol overflows into your bloodstream
So the alcohol overflows into your bloodstream

and travels to other organs like your brain.
and travels to other organs like your brain.

There, it suppresses a hormone called vasopressin.
There, it suppresses a hormone called vasopressin.

Normally, vasopressin prevents you from urinating too much.
Normally, vasopressin prevents you from urinating too much.

So without it, you have to pee all the time,
So without it, you have to pee all the time,

dehydrating you in the process,
dehydrating you in the process,

and that helps explain your brutal headache
and that helps explain your brutal headache

the next morning.
the next morning.

But there are other chemicals at work,
But there are other chemicals at work,

such as proinflammatory cytokines.
such as proinflammatory cytokines.

These are small proteins that stimulate inflammation,
These are small proteins that stimulate inflammation,

which causes symptoms like nausea, jitters, and headaches.
which causes symptoms like nausea, jitters, and headaches.

And people who are hungover
And people who are hungover

have tons of them in their blood.
have tons of them in their blood.

In fact, when researchers injected proinflammatory cytokines
In fact, when researchers injected proinflammatory cytokines

into people who were stone-cold sober,
into people who were stone-cold sober,

they actually felt hungover without all the fun beforehand.
they actually felt hungover without all the fun beforehand.

What a rip-off.
What a rip-off.

Now, scientists aren't exactly sure why binging
Now, scientists aren't exactly sure why binging

triggers this kind of inflammatory response,
triggers this kind of inflammatory response,

but there is some evidence that it's more severe
but there is some evidence that it's more severe

when you drink darker alcohols.
when you drink darker alcohols.

In one study, participants who drank bourbon
In one study, participants who drank bourbon

instead of vodka reported that their hangover symptoms
instead of vodka reported that their hangover symptoms

were 36% worse the next morning.
were 36% worse the next morning.

Then, there's that awful morning anxiety called "hangxiety."
Then, there's that awful morning anxiety called "hangxiety."

And no, it's not the guilt that you feel
And no, it's not the guilt that you feel

from all the bad decisions you made the night before.
from all the bad decisions you made the night before.

It's actually biological.
It's actually biological.

Hangxiety starts to develop when you finally put down
Hangxiety starts to develop when you finally put down

that last empty cocktail glass.
that last empty cocktail glass.

You see, up until that point, your brain
You see, up until that point, your brain

has been ramping up the activity of receptors
has been ramping up the activity of receptors

called G-A-B-A, giving you that calming buzz.
called G-A-B-A, giving you that calming buzz.

And at the same time, it's been blocking glutamate,
And at the same time, it's been blocking glutamate,

a stimulant linked to anxiety.
a stimulant linked to anxiety.

But when you stop drinking,
But when you stop drinking,

that whole system flips right around.
that whole system flips right around.

Your brain empties those calming G-A-B-A receptors
Your brain empties those calming G-A-B-A receptors

and floods with stimulating glutamate,
and floods with stimulating glutamate,

which can make you feel abnormally anxious
which can make you feel abnormally anxious

by the time morning comes around.
by the time morning comes around.

It can also disrupt your sleep so you wake up still tired.
It can also disrupt your sleep so you wake up still tired.

But enough with all that bad news.
But enough with all that bad news.

You want to know how you can make
You want to know how you can make

that nasty hangover a thing of the past.
that nasty hangover a thing of the past.

Sorry to say, but that delicious, greasy breakfast
Sorry to say, but that delicious, greasy breakfast

isn't doing you any favors.
isn't doing you any favors.

Your body is running low on water, not fat.
Your body is running low on water, not fat.

So your best bet is to hydrate
So your best bet is to hydrate

and take an anti-inflammatory.
and take an anti-inflammatory.

Chances are the hangover will vanish within 24 hours
Chances are the hangover will vanish within 24 hours

or at least in time for next weekend.
or at least in time for next weekend.

Uh, hello, my good friend?
Uh, hello, my good friend?

Yes, I'd love to go to the big party,
Yes, I'd love to go to the big party,

and I will be drinking a lot of alcohol as well.
and I will be drinking a lot of alcohol as well.