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  • 00:00

    [BEEPS AND STATIC]
    [BEEPS AND STATIC]

  • 00:07

    [MUSIC PLAYING]
    [MUSIC PLAYING]

  • 00:12

    NINA MAK: When the media covers pet cloning, it's often
    NINA MAK: When the media covers pet cloning, it's often

  • 00:15

    fluff pieces and these warm, fuzzy pieces about, oh, look
    fluff pieces and these warm, fuzzy pieces about, oh, look

  • 00:19

    how cute these animals are and isn't it cool
    how cute these animals are and isn't it cool

  • 00:21

    that we could do this?
    that we could do this?

  • 00:22

    And there's very little coverage, if any, of what it
    And there's very little coverage, if any, of what it

  • 00:27

    really meant to clone that animal and what it took.
    really meant to clone that animal and what it took.

  • 00:30

    DR. DUANE KRAEMER: I think it more of reproduction.
    DR. DUANE KRAEMER: I think it more of reproduction.

  • 00:32

    If we had created her, we'd have started from
    If we had created her, we'd have started from

  • 00:35

    nothing and made her.
    nothing and made her.

  • 00:37

    But we started with ova from other cats and cells from
    But we started with ova from other cats and cells from

  • 00:42

    another cat and just put them together in a way that they
    another cat and just put them together in a way that they

  • 00:45

    could reproduce.
    could reproduce.

  • 00:47

    That's not vastly different than people
    That's not vastly different than people

  • 00:50

    that arrange for mating.
    that arrange for mating.

  • 00:50

    It's just that we threw in some technology.
    It's just that we threw in some technology.

  • 00:59

    [MUSIC PLAYING]
    [MUSIC PLAYING]

  • 01:16

    DR. DUANE KRAEMER: I'm Duane Kraemer.
    DR. DUANE KRAEMER: I'm Duane Kraemer.

  • 01:18

    I'm a professor at Texas A&M University.
    I'm a professor at Texas A&M University.

  • 01:21

    I've been working in the area of embryo transfer cloning and
    I've been working in the area of embryo transfer cloning and

  • 01:25

    genetic engineering.
    genetic engineering.

  • 01:32

    My dream was to become a farmer.
    My dream was to become a farmer.

  • 01:34

    And I went to the university intending to just get what I
    And I went to the university intending to just get what I

  • 01:39

    needed to come back.
    needed to come back.

  • 01:40

    And then I got bit by the research bug.
    And then I got bit by the research bug.

  • 01:43

    My father was very disappointed that I didn't
    My father was very disappointed that I didn't

  • 01:46

    come back to the farm.
    come back to the farm.

  • 01:48

    My mother said, well, I knew you'd find something better.
    My mother said, well, I knew you'd find something better.

  • 01:52

    And I didn't mean that it was better, it was just different.
    And I didn't mean that it was better, it was just different.

  • 01:58

    Cloning, as it's most customarily practiced at the
    Cloning, as it's most customarily practiced at the

  • 02:02

    present, involves the transfer of nuclei from cells and
    present, involves the transfer of nuclei from cells and

  • 02:07

    transferring those cells into eggs where the nucleus has
    transferring those cells into eggs where the nucleus has

  • 02:11

    been removed, and then the nucleus from the animal to be
    been removed, and then the nucleus from the animal to be

  • 02:14

    cloned is put in its place.
    cloned is put in its place.

  • 02:16

    If it's a mammal, those new embryos then have to be
    If it's a mammal, those new embryos then have to be

  • 02:20

    transferred into recipient females for them
    transferred into recipient females for them

  • 02:24

    to carry on to term.
    to carry on to term.

  • 02:26

    And usually, those recipient animals nurse them and raise
    And usually, those recipient animals nurse them and raise

  • 02:30

    them as well.
    them as well.

  • 02:35

    This is the first of the deer to be cloned.
    This is the first of the deer to be cloned.

  • 02:38

    This is Dewey.
    This is Dewey.

  • 02:40

    Students named him after me.
    Students named him after me.

  • 02:42

    I think it's because I insisted that he be allowed to
    I think it's because I insisted that he be allowed to

  • 02:46

    be born natural birth.
    be born natural birth.

  • 02:48

    And he survived.
    And he survived.

  • 02:49

    I think that earned me that privilege, I guess.
    I think that earned me that privilege, I guess.

  • 02:55

    NINA MAK: The truth is that cloning is highly experimental
    NINA MAK: The truth is that cloning is highly experimental

  • 02:58

    and very problematic.
    and very problematic.

  • 03:00

    And most of the time, it doesn't work.
    And most of the time, it doesn't work.

  • 03:03

    Only a few clones have actually been born
    Only a few clones have actually been born

  • 03:05

    successfully.
    successfully.

  • 03:06

    And of the ones that have been, a good percentage
    And of the ones that have been, a good percentage

  • 03:09

    actually end up dying within the first six months, because
    actually end up dying within the first six months, because

  • 03:12

    they have some sort of complication, health
    they have some sort of complication, health

  • 03:13

    abnormality, a physical deformity,
    abnormality, a physical deformity,

  • 03:15

    something like that.
    something like that.

  • 03:16

    You talk about using a very large number of animals to
    You talk about using a very large number of animals to

  • 03:19

    even try to produce just one clone.
    even try to produce just one clone.

  • 03:23

    DR. DUANE KRAEMER: Some people just don't like anything
    DR. DUANE KRAEMER: Some people just don't like anything

  • 03:24

    that's unnatural and think they can abide by that.
    that's unnatural and think they can abide by that.

  • 03:30

    But of course, most of the things they do are unnatural.
    But of course, most of the things they do are unnatural.

  • 03:33

    I think it has to do with the Hollywood version, to some
    I think it has to do with the Hollywood version, to some

  • 03:37

    extent, of cloning.
    extent, of cloning.

  • 03:39

    They have always pretty much made it a
    They have always pretty much made it a

  • 03:41

    monster kind of activity.
    monster kind of activity.

  • 03:44

    Well, I hope that there will be continued research to make
    Well, I hope that there will be continued research to make

  • 03:48

    it more dependable.
    it more dependable.

  • 03:51

    At present, about 25% of offspring have some type of
    At present, about 25% of offspring have some type of

  • 03:56

    abnormality.
    abnormality.

  • 03:57

    They're developmental abnormalities.
    They're developmental abnormalities.

  • 04:00

    They're not mutations.
    They're not mutations.

  • 04:01

    They don't get passed on to the next generation.
    They don't get passed on to the next generation.

  • 04:04

    But they need special care.
    But they need special care.

  • 04:06

    [MUSIC PLAYING]
    [MUSIC PLAYING]

  • 04:13

    DR. DUANE KRAEMER: These are microscopes we
    DR. DUANE KRAEMER: These are microscopes we

  • 04:15

    use to find the eggs.
    use to find the eggs.

  • 04:18

    We have to get the eggs out of ovaries.
    We have to get the eggs out of ovaries.

  • 04:21

    It is simple after you learn how to do it.
    It is simple after you learn how to do it.

  • 04:24

    But there are just many, many details
    But there are just many, many details

  • 04:28

    that have to be followed.
    that have to be followed.

  • 04:29

    And if you do one thing wrong, then the chain is broken and
    And if you do one thing wrong, then the chain is broken and

  • 04:35

    you get nothing from it.
    you get nothing from it.

  • 04:38

    Well, our team is working on a genetic engineering of
    Well, our team is working on a genetic engineering of

  • 04:41

    livestock to produce animals that are resistant to disease.
    livestock to produce animals that are resistant to disease.

  • 04:48

    This is the cloned bull that's resistant to brucellosis,
    This is the cloned bull that's resistant to brucellosis,

  • 04:52

    which is a disease that causes abortion in cattle and
    which is a disease that causes abortion in cattle and

  • 04:55

    undulant fever in humans.
    undulant fever in humans.

  • 04:58

    The original bull was naturally resistant to it.
    The original bull was naturally resistant to it.

  • 05:00

    His cells that were used for cloning him have been stored
    His cells that were used for cloning him have been stored

  • 05:05

    for 15 years.
    for 15 years.

  • 05:07

    His name is Bruce after brucellosis.
    His name is Bruce after brucellosis.

  • 05:11

    The process of selective breeding to produce superior
    The process of selective breeding to produce superior

  • 05:14

    individuals has been going on for many years, even using
    individuals has been going on for many years, even using

  • 05:17

    natural breeding.
    natural breeding.

  • 05:18

    And then embryo transfer and artificial insemination made
    And then embryo transfer and artificial insemination made

  • 05:22

    that process more efficient, where you could get more
    that process more efficient, where you could get more

  • 05:24

    offspring from the genetically valuable animals.
    offspring from the genetically valuable animals.

  • 05:27

    If they're superior and can't reproduce by themselves, then
    If they're superior and can't reproduce by themselves, then

  • 05:32

    the techniques such as cloning can produce offspring.
    the techniques such as cloning can produce offspring.

  • 05:38

    Anything we do could be used incorrectly and wrongly.
    Anything we do could be used incorrectly and wrongly.

  • 05:44

    And most things are by somebody somewhere, sometime.
    And most things are by somebody somewhere, sometime.

  • 05:48

    GEORGE W. BUSH: Chinese scientists have derived stem
    GEORGE W. BUSH: Chinese scientists have derived stem

  • 05:51

    cells from cloned embryos created by combining human DNA
    cells from cloned embryos created by combining human DNA

  • 05:57

    and rabbit eggs.
    and rabbit eggs.

  • 06:00

    Others have announced plans to produce cloned children,
    Others have announced plans to produce cloned children,

  • 06:05

    despite the fact that laboratory cloning of animals
    despite the fact that laboratory cloning of animals

  • 06:08

    has led to spontaneous abortions and terrible,
    has led to spontaneous abortions and terrible,

  • 06:11

    terrible abnormalities.
    terrible abnormalities.

  • 06:14

    Human cloning is deeply troubling to
    Human cloning is deeply troubling to

  • 06:17

    me and to most Americans.
    me and to most Americans.

  • 06:20

    DR. DUANE KRAEMER: The issue of human cell storage is one
    DR. DUANE KRAEMER: The issue of human cell storage is one

  • 06:24

    that we have not dealt with.
    that we have not dealt with.

  • 06:26

    We don't have any--
    We don't have any--

  • 06:27

    don't even have my cells stored here.
    don't even have my cells stored here.

  • 06:30

    We have not worked at all with the human cells.
    We have not worked at all with the human cells.

  • 06:34

    Anyone who could effectively culture and preserve cells
    Anyone who could effectively culture and preserve cells

  • 06:39

    from animals would be able to do so with humans as well.
    from animals would be able to do so with humans as well.

  • 06:45

    [MUSIC PLAYING]
    [MUSIC PLAYING]

  • 06:48

    DR. DUANE KRAEMER: I still get goose bumps
    DR. DUANE KRAEMER: I still get goose bumps

  • 06:50

    when I see an embryo.
    when I see an embryo.

  • 06:51

    It's just kind of thrilling to be able to see something as
    It's just kind of thrilling to be able to see something as

  • 06:55

    simple as a little embryo that you know can develop into
    simple as a little embryo that you know can develop into

  • 06:58

    something as complex as a complete individual.
    something as complex as a complete individual.

  • 07:04

    CC was, I think, a special cat, because she was the first
    CC was, I think, a special cat, because she was the first

  • 07:08

    of the pets to be cloned.
    of the pets to be cloned.

  • 07:12

    It's not a new creation.
    It's not a new creation.

  • 07:14

    We're just helping with reproduction.
    We're just helping with reproduction.

  • 07:17

    Cats had more to do with it than we did.
    Cats had more to do with it than we did.

  • 07:18

    It was their eggs that made it possible and the recipient
    It was their eggs that made it possible and the recipient

  • 07:22

    that made it possible.
    that made it possible.

  • 07:23

    I'm pleased with the result and pleased to have been a
    I'm pleased with the result and pleased to have been a

  • 07:27

    part of it.
    part of it.

  • 07:28

    [MUSIC PLAYING]
    [MUSIC PLAYING]

  • 07:36

    SHIRLEY KRAEMER: Come on over and meet those kitties.
    SHIRLEY KRAEMER: Come on over and meet those kitties.

  • 07:38

    -Yeah.
    -Yeah.

  • 07:39

    SHIRLEY KRAEMER: Yeah, come on over.
    SHIRLEY KRAEMER: Yeah, come on over.

  • 07:40

    -Grazie.
    -Grazie.

  • 07:40

    SHIRLEY KRAEMER: Right over here's their house.
    SHIRLEY KRAEMER: Right over here's their house.

  • 07:45

    DR. DUANE KRAEMER: She's up in that window.
    DR. DUANE KRAEMER: She's up in that window.

  • 07:46

    SHIRLEY KRAEMER: She's up in that window.
    SHIRLEY KRAEMER: She's up in that window.

  • 07:47

    And that's her favorite place.
    And that's her favorite place.

  • 07:49

    [MUSIC PLAYING]
    [MUSIC PLAYING]

  • 07:58

    SHIRLEY KRAEMER: Hi, CC.
    SHIRLEY KRAEMER: Hi, CC.

  • 07:58

    Come on.
    Come on.

  • 07:58

    Say hello, CC.
    Say hello, CC.

  • 08:00

    Hi, Cece, how you doing?
    Hi, Cece, how you doing?

  • 08:03

    How you doing, CC?
    How you doing, CC?

  • 08:04

    I worried when CC was expecting.
    I worried when CC was expecting.

  • 08:07

    I thought, oh, what if she's born with two children without
    I thought, oh, what if she's born with two children without

  • 08:10

    ears and one without a tail?
    ears and one without a tail?

  • 08:12

    I'm going to have to say, oh, this is not good.
    I'm going to have to say, oh, this is not good.

  • 08:14

    But she came through for us.
    But she came through for us.

  • 08:17

    She came through.
    She came through.

  • 08:18

    CC came through.
    CC came through.

  • 08:19

    CC's a good kitty.
    CC's a good kitty.

  • 08:21

    CC's a good kitty.
    CC's a good kitty.

  • 08:22

    She said, I know, I know.
    She said, I know, I know.

  • 08:26

    She knew exactly what to do.
    She knew exactly what to do.

  • 08:28

    I really worried about that, because I thought, I'm going
    I really worried about that, because I thought, I'm going

  • 08:30

    to have to buy little bottles and feed each kitten.
    to have to buy little bottles and feed each kitten.

  • 08:33

    No, I didn't have to.
    No, I didn't have to.

  • 08:35

    She was a wonderful mother.
    She was a wonderful mother.

  • 08:37

    DR. DUANE KRAEMER: It's in the genes.
    DR. DUANE KRAEMER: It's in the genes.

  • 08:38

    SHIRLEY KRAEMER: It's in the genes.
    SHIRLEY KRAEMER: It's in the genes.

  • 08:39

    DR. DUANE KRAEMER: Different species have different
    DR. DUANE KRAEMER: Different species have different

  • 08:40

    instincts and behaviors.
    instincts and behaviors.

  • 08:43

    That's one thing about the clones.
    That's one thing about the clones.

  • 08:44

    They all act like their own species.
    They all act like their own species.

  • 08:46

    SHIRLEY KRAEMER: Species, yeah.
    SHIRLEY KRAEMER: Species, yeah.

  • 08:48

    DR. DUANE KRAEMER: It's a privilege to have been in a
    DR. DUANE KRAEMER: It's a privilege to have been in a

  • 08:50

    situation where we could do this and also to be able to
    situation where we could do this and also to be able to

  • 08:53

    enjoy her is an added privilege.
    enjoy her is an added privilege.

  • 08:59

    If people want to use their resources to get a genetic
    If people want to use their resources to get a genetic

  • 09:03

    copy of their original pet, I don't see
    copy of their original pet, I don't see

  • 09:06

    anything wrong with that.
    anything wrong with that.

  • 09:07

    NINA MAK: There's a life that gets lived-- a beginning,
    NINA MAK: There's a life that gets lived-- a beginning,

  • 09:09

    middle, and an end.
    middle, and an end.

  • 09:10

    And it's hard to deal with the end.
    And it's hard to deal with the end.

  • 09:13

    But that's part of life.
    But that's part of life.

  • 09:15

    And trying to prevent that from being a part of life with
    And trying to prevent that from being a part of life with

  • 09:18

    this idea that you could somehow have the same animal
    this idea that you could somehow have the same animal

  • 09:20

    your whole life--
    your whole life--

  • 09:21

    these are still animals, and they still very much matter.
    these are still animals, and they still very much matter.

  • 09:24

    And to treat them like objects, it's not really
    And to treat them like objects, it's not really

  • 09:31

    something that I find acceptable.
    something that I find acceptable.

  • 09:33

    DR. DUANE KRAEMER: They say, accusatory, you're playing
    DR. DUANE KRAEMER: They say, accusatory, you're playing

  • 09:37

    God, creating something.
    God, creating something.

  • 09:40

    No more than anybody else is creating.
    No more than anybody else is creating.

  • 09:43

    Besides, I'm doing it to serve God, not to take his place.
    Besides, I'm doing it to serve God, not to take his place.

  • 09:48

    And I'm not playing.
    And I'm not playing.

  • 09:49

    This is my vocation--
    This is my vocation--

  • 09:52

    work, but really good work.
    work, but really good work.

  • 09:56

    SHIRLEY KRAEMER: There you go, CC.
    SHIRLEY KRAEMER: There you go, CC.

  • 09:57

    [MUSIC PLAYING]
    [MUSIC PLAYING]

All

How to Clone Animals

492,485 views

Intro:

[BEEPS AND STATIC]. [MUSIC PLAYING]. NINA MAK: When the media covers pet cloning, it's often
fluff pieces and these warm, fuzzy pieces about, oh, look
how cute these animals are and isn't it cool. that we could do this?. And there's very little coverage, if any, of what it
really meant to clone that animal and what it took.
DR. DUANE KRAEMER: I think it more of reproduction.
If we had created her, we'd have started from. nothing and made her.. But we started with ova from other cats and cells from
another cat and just put them together in a way that they
could reproduce.. That's not vastly different than people. that arrange for mating.. It's just that we threw in some technology.. [MUSIC PLAYING]. DR. DUANE KRAEMER: I'm Duane Kraemer.. I'm a professor at Texas A&M University..

Video Vocabulary

/ˈdif(ə)rənt/

adjective

Not of the same kind; unlike other things.

/ˈanəməl/

noun other

living organism. Living creatures that are not plants or people.

/ˈnəTHiNG/

adjective adverb noun pronoun

of no value. not at all. Number or value of zero. not anything.

noun verb

Moving to a different place, job, or school. To give someone your right to a property.

/ˈwərkiNG/

adjective noun verb

Doing your job. action of doing work. To be functioning properly, e.g. a car.

/inˈtendiNG/

adjective verb

planning or meaning to do or be specified thing. To plan or want to do something.

/əˈrānj/

verb

To organize events so they happen.

/təˈɡeT͟Hər/

adjective adverb

self-confident, level-headed, or well organized. With the same physical position.

/jəˈnedik/

adjective

relating to genes or heredity.

/prəˈfesər/

noun

university academic of highest rank.

/klōn/

noun verb

Creating an exact copy of a cell, gene, etc.. make genetic clone of.

/ˌyo͞onəˈvərsədē/

noun

High-level educational institution; college.

/əˈnəT͟Hər/

adjective determiner pronoun

One more, but not this. One more added. One more (thing).

/stärt/

verb

begin or be reckoned from particular point in time or space.

/krēˈāt/

verb

To make, cause, or bring into existence.