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  • 00:00

    We at Crash Course and our  partners Operation Outbreak
    We at Crash Course and our  partners Operation Outbreak

  • 00:02

    and the Sabeti Lab at the Broad  Institute at MIT and Harvard
    and the Sabeti Lab at the Broad  Institute at MIT and Harvard

  • 00:06

    want to acknowledge the Indigenous people  native to the land we live and work on,
    want to acknowledge the Indigenous people  native to the land we live and work on,

  • 00:10

    and their traditional and ongoing  relationship with this land.
    and their traditional and ongoing  relationship with this land.

  • 00:13

    We encourage you to learn about the  history of the place you call home
    We encourage you to learn about the  history of the place you call home

  • 00:16

    through resources like native-land.ca
    through resources like native-land.ca

  • 00:18

    and by engaging with your local  Indigenous and Aboriginal nations
    and by engaging with your local  Indigenous and Aboriginal nations

  • 00:21

    through the websites and resources they provide.
    through the websites and resources they provide.

  • 00:24

    A single virus is about one  thousandth the width of a human hair.
    A single virus is about one  thousandth the width of a human hair.

  • 00:27

    And yet they have the capacity to wreak  havoc on nearly all human life on Earth.
    And yet they have the capacity to wreak  havoc on nearly all human life on Earth.

  • 00:32

    Although we saw this play out when  the Covid-19 pandemic emerged in 2020,
    Although we saw this play out when  the Covid-19 pandemic emerged in 2020,

  • 00:35

    it still feels a little unbelievable.
    it still feels a little unbelievable.

  • 00:37

    And the same big questions about  infectious disease outbreaks we  
    And the same big questions about  infectious disease outbreaks we  

  • 00:40

    had before Covid-19 are as important as ever.
    had before Covid-19 are as important as ever.

  • 00:43

    What do pathogens actually  do to us that makes us sick?
    What do pathogens actually  do to us that makes us sick?

  • 00:46

    Why do societies respond to outbreaks  of infectious diseases the way they do?
    Why do societies respond to outbreaks  of infectious diseases the way they do?

  • 00:50

    And most importantly, how can  all of us help stop the next one?
    And most importantly, how can  all of us help stop the next one?

  • 00:54

    These are the kinds of questions we ask ourselves  in what we’ll collectively call Outbreak Science,
    These are the kinds of questions we ask ourselves  in what we’ll collectively call Outbreak Science,

  • 00:59

    which covers the many ways of  looking at epidemics, pandemics,
    which covers the many ways of  looking at epidemics, pandemics,

  • 01:02

    and really any time an infectious disease  starts affecting more people than expected.
    and really any time an infectious disease  starts affecting more people than expected.

  • 01:05

    I’m Pardis Sabeti, and welcome  to Crash Course Outbreak Science!
    I’m Pardis Sabeti, and welcome  to Crash Course Outbreak Science!

  • 01:08

    I’m a geneticist who studies pathogens,
    I’m a geneticist who studies pathogens,

  • 01:11

    tiny foreign invaders that  infect humans and cause disease.
    tiny foreign invaders that  infect humans and cause disease.

  • 01:14

    I’ve spent over two decades developing genetic  
    I’ve spent over two decades developing genetic  

  • 01:17

    tools that shed light on how  our relationship to pathogens,
    tools that shed light on how  our relationship to pathogens,

  • 01:20

    past and present, has shaped  our history, lives and biology.
    past and present, has shaped  our history, lives and biology.

  • 01:24

    As a professor at Harvard University,
    As a professor at Harvard University,

  • 01:26

    I work with an amazing collective of scientists at  the Broad Institute in Cambridge, Massachusetts.
    I work with an amazing collective of scientists at  the Broad Institute in Cambridge, Massachusetts.

  • 01:30

    My team and I have also spent time in West Africa  studying deadly viruses like Lassa and Ebola.
    My team and I have also spent time in West Africa  studying deadly viruses like Lassa and Ebola.

  • 01:36

    In 2014, we found ourselves on the front  line of the Ebola outbreak in Sierra Leone.
    In 2014, we found ourselves on the front  line of the Ebola outbreak in Sierra Leone.

  • 01:41

    Using genetic techniques we  had been developing for years,
    Using genetic techniques we  had been developing for years,

  • 01:44

    we helped to uncover the course of  Ebola from its animal origins to humans,
    we helped to uncover the course of  Ebola from its animal origins to humans,

  • 01:48

    and the mutations that helped it on its path.
    and the mutations that helped it on its path.

  • 01:50

    Tracking the history of a pathogen through its  genes is one fascinating part of outbreak science.
    Tracking the history of a pathogen through its  genes is one fascinating part of outbreak science.

  • 01:55

    But outbreak science incorporates  
    But outbreak science incorporates  

  • 01:56

    lots of disciplines that help explain  the mechanics of infectious diseases
    lots of disciplines that help explain  the mechanics of infectious diseases

  • 02:00

    and how we can intervene to  break the cycle of transmission.
    and how we can intervene to  break the cycle of transmission.

  • 02:03

    To tackle outbreaks, scientists  use techniques from epidemiology,  
    To tackle outbreaks, scientists  use techniques from epidemiology,  

  • 02:07

    anthropology, microbiology, sociology, and more
    anthropology, microbiology, sociology, and more

  • 02:10

    to better understand the drivers  of diseases and identify the ways  
    to better understand the drivers  of diseases and identify the ways  

  • 02:13

    we can act to keep ourselves safe.
    we can act to keep ourselves safe.

  • 02:15

    In many ways, outbreak science is about  
    In many ways, outbreak science is about  

  • 02:17

    us and our interactions with each  other and the world around us.
    us and our interactions with each  other and the world around us.

  • 02:21

    Over the course of this series, we’ll  look at where outbreaks come from,
    Over the course of this series, we’ll  look at where outbreaks come from,

  • 02:24

    and how the way we live creates new risks for  diseases to spring up and spread amongst us.
    and how the way we live creates new risks for  diseases to spring up and spread amongst us.

  • 02:29

    We’ll take a trip through the history of  outbreaks, and how different pathogens,
    We’ll take a trip through the history of  outbreaks, and how different pathogens,

  • 02:32

    from bacteria to viruses, have shaped  civilizations, from their economies to warfare.
    from bacteria to viruses, have shaped  civilizations, from their economies to warfare.

  • 02:37

    We’ll learn how to become germ detectives  and equip ourselves with scientific methods
    We’ll learn how to become germ detectives  and equip ourselves with scientific methods

  • 02:41

    that let us spot, track, defend against, and even eradicate  the pathogens behind infectious diseases.
    that let us spot, track, defend against, and even eradicate  the pathogens behind infectious diseases.

  • 02:47

    And at the heart of it all, we’ll understand  
    And at the heart of it all, we’ll understand  

  • 02:49

    the people whose actions shape how  outbreaks progress– including you!
    the people whose actions shape how  outbreaks progress– including you!

  • 02:53

    Even though diseases spread from person to person,
    Even though diseases spread from person to person,

  • 02:55

    our capacity to connect with  one another and create fair,  
    our capacity to connect with  one another and create fair,  

  • 02:58

    sustainable and resilient social systems
    sustainable and resilient social systems

  • 03:00

    is one of the most powerful tools we have  at keeping ourselves safe from disease.
    is one of the most powerful tools we have  at keeping ourselves safe from disease.

  • 03:04

    I’ve seen this first hand, on  the ground during real outbreaks,
    I’ve seen this first hand, on  the ground during real outbreaks,

  • 03:08

    where health professionals and  scientists have collaborated,
    where health professionals and  scientists have collaborated,

  • 03:11

    risked their own lives, and sometimes  even tragically lost them, to help others.
    risked their own lives, and sometimes  even tragically lost them, to help others.

  • 03:15

    These remarkable acts of teamwork and  heroism show the high stakes of outbreaks,
    These remarkable acts of teamwork and  heroism show the high stakes of outbreaks,

  • 03:20

    and the importance of structures that can  support us in the face of future outbreaks.
    and the importance of structures that can  support us in the face of future outbreaks.

  • 03:24

    So, we’ll have whole episodes about  how public health organizations,
    So, we’ll have whole episodes about  how public health organizations,

  • 03:28

    governments and even physical infrastructure  like roads and computer networks
    governments and even physical infrastructure  like roads and computer networks

  • 03:32

    help different groups tackle and  prevent outbreaks in the first place,
    help different groups tackle and  prevent outbreaks in the first place,

  • 03:35

    ultimately saving lives.
    ultimately saving lives.

  • 03:37

    Because while it’s easy to think this all happens  automatically as part of scientific progress,
    Because while it’s easy to think this all happens  automatically as part of scientific progress,

  • 03:41

    in reality, systems like this come together  because individuals make choices to cooperate,
    in reality, systems like this come together  because individuals make choices to cooperate,

  • 03:46

    consider the big picture  and learn from one another.
    consider the big picture  and learn from one another.

  • 03:49

    We hope you’ll join us in learning about  outbreak science, so that together,
    We hope you’ll join us in learning about  outbreak science, so that together,

  • 03:53

    we can go a step further in stopping outbreaks  and ensure healthier futures for everyone.
    we can go a step further in stopping outbreaks  and ensure healthier futures for everyone.

  • 03:57

    Thanks for watching this episode  of Crash Course Outbreak Science,
    Thanks for watching this episode  of Crash Course Outbreak Science,

  • 04:00

    which was produced by Complexly in  partnership with Operation Outbreak  
    which was produced by Complexly in  partnership with Operation Outbreak  

  • 04:04

    and the Sabeti Lab at the Broad  Institute of MIT and Harvard—
    and the Sabeti Lab at the Broad  Institute of MIT and Harvard—

  • 04:07

    with generous support from the  Gordon and Betty Moore Foundation.
    with generous support from the  Gordon and Betty Moore Foundation.

  • 04:10

    If you want to help keep Crash  Course free for everyone, forever,  
    If you want to help keep Crash  Course free for everyone, forever,  

  • 04:13

    you can join our community on Patreon.
    you can join our community on Patreon.

All idiom
crash course
//

idiom

a short and intense training course in something.

Crash Course Outbreak Science Preview

106,060 views

Video Language:

  • English

Caption Language:

  • English (en)

Accent:

  • English (US)

Speech Time:

97%
  • 4:13 / 4:20

Speech Rate:

  • 192 wpm - Fast

Category:

  • Education

Intro:

We at Crash Course and our  partners Operation Outbreak
and the Sabeti Lab at the Broad  Institute at MIT and Harvard
want to acknowledge the Indigenous people  native to the land we live and work on,
and their traditional and ongoing  relationship with this land.
We encourage you to learn about the  history of the place you call home
through resources like native-land.ca. and by engaging with your local  Indigenous and Aboriginal nations
through the websites and resources they provide.. A single virus is about one  thousandth the width of a human hair.
And yet they have the capacity to wreak  havoc on nearly all human life on Earth.
Although we saw this play out when  the Covid-19 pandemic emerged in 2020,
it still feels a little unbelievable.. And the same big questions about  infectious disease outbreaks we  
had before Covid-19 are as important as ever.. What do pathogens actually  do to us that makes us sick?
Why do societies respond to outbreaks  of infectious diseases the way they do?
And most importantly, how can  all of us help stop the next one?
These are the kinds of questions we ask ourselves  in what we’ll collectively call Outbreak Science,
which covers the many ways of  looking at epidemics, pandemics,
and really any time an infectious disease  starts affecting more people than expected.

Video Vocabulary

/ˈpaTHəjən/

noun other

bacterium, virus, or other microorganism. Any disease-producing agent.

/əˈfektiNG/

adjective verb

Putting on an act; not genuine. To cause a change in something else.

/səˈsīədē/

noun other

aggregate of people living together in more. Communities of people living together.

/ˈstədē/

noun other verb

devotion of time and attention to gaining knowledge of academic subject. Rooms that a person studies or reads in. devote time and attention to gaining knowledge of academic subject.

/ˈkwesCH(ə)n/

noun other verb

sentence worded or expressed so as to elicit information. Issues or problems you are dealing with. ask someone questions.

/ˈwebsīt/

noun other

set of related web pages located under single domain name. Collections of webpages in one location.

/ˈdekād/

noun other

period of ten years. Periods of 10 years.

/jəˈnedəsəst/

noun

Biologist who specializes in genetics.

noun

1000th.

/əkˈnäləj/

verb

accept as true.

/ˈoutˌbrāk/

noun other

sudden occurrence of something unwelcome. Sudden occurrence of illness, discontent etc..

/rəˈspänd/

noun verb

half-pillar or half-pier attached to wall to support arch. To answer something or someone.