So today we'll talk about the new addition
to the family of Gluten Free Remedies.
The new product is Sulbutiamine Plus.
This is the first brain permeable Vitamin B1
which is designed to treat mainly patients with
chronic fatigue. The story behind Sulbutiamine
is quite interesting. So what's been shown
many years ago that patients who have
chronic fatigue syndrome, they have low levels
of Vitamin B1 in their brain tissue not in the blood
or peripheral tissues. And what is more interesting
is that if you take Vitamin B1 in the native form,
it doesn't penetrate into the brain tissue well enough.
And people with chronic fatigue syndrome are
still deficient of this vital vitamin.
So the first attempt was to create a first generation
of Vitamin B1 with better fat solubility and better penetration
into the brain and so the first vitamin was Benfotiamine,
but still it barely penetrated into the brain through
the blood-brain barrier. So a few years ago in Japan
a new product was designed, which is Sulbutiamine.
Sulbutiamine represents a dimer of Vitamin B1
or thiamin. What it means is two molecules of
Vitamin B1 are bound together.
So it's extremely lipophilic meaning that it's fat soluable
and because of that, it penetrates into the brain tissue
much much better than thiamin or Benfotiamine.
So what's been shown in many clinical studies
as well as in animal studies that Sulbutiamine can cross
through blood-brain barrier and it converts into
the real Vitamin B1, which is a biologically active B1
within the brain tissue. So outside of the United States
in Japan and in Europe, Sulbutiamine is used as a
prescription remedy to treat chronic fatigue syndrome
and weakness specifically due to chronic infections.
For example, Lyme disease, chronic streptococcal infections,
mycoplasma infection, Epstein-Barr virus, CMV and
so on and so on. As well as a remedy to treat fatigue
due to various inflammatory processes such as
multiple sclerosis for example.
So we decided to improve the efficacy of just plain
Sulbutiamine and so I found a lot of studies on its
mechanism of action and permeability into the brain tissue.
And we came up with a proprietary formulation
which in addition to Sulbutiamine contains also
Milk Thistle, Aplha Lipoic Acid, and Piperine.
And this product is supposed to have better
biological availability of Sulbutiamine.
So what is known about the mechanism of
Sulbutiamine activity? So the data came from
mainly animal research as well as clinical studies.
So what is shown is that Sulbutiamine protects
neuronal cells from oxygen and glucose deprivation.
It restores nerve function in patients with diabetic neuropathy.
So it can be used as adjunct therapy for those who
suffer from diabetes and who have nerve damage
from diabetes. So it also improves neuronal cell
communication within the brain. And that is something
which is mediated via glutamine, choline, and
dopamine-dependent pathways and corresponding
receptors. So in clinical trials it has been shown
that Sulbutiamine definitely improves memory and it
can be used in patients with brain fog and some
minor cognitive problems. It reduces fatigue and
also what is more important is that it slows down
or attenuates neuronal cell death and therefore it can be
used in patients who sustained strokes within
a day or so after the acute onset of the stroke.
So based on the mechanism of its activity,
Sulbutiamine Plus should be very synergistic with
DMAE Plus, and that's something which we are using
in our clinic. The combination of DMAE Plus, plus
Sulbutiamine Plus. It also should be very synergistic
with major methylators such as methyl B12 or
methylcobalamin as well as methylfolate. In addition
there is a mechanism which links Sulbutiamine to
7-Keto and Pregnenolone. Also Sulbutiamine can
amplify the efficacy of Cordyceps, Rhodiola, and Eleutherococcus.
So in general based on our personal clinical
observations this is a product which is very well
tolerated without any major side effects. There is
one warning. Certain clinical publications indicate
that Sulbutiamine Plus cannot be used in patients
with poorly controlled bipolar disorder.
Because it can worsen specifically manic episodes.
And therefore we don't recommend to use this
particular supplement for patients who deal with
that disorder.