"Pesticides (DDT) and Alzheimer’s Disease"
Although there is a growing list of Alzheimer's disease
susceptibility genes, even if you put them all altogether,
they account for less than half of all Alzheimer's cases.
The single most compelling piece of data on the potential control
we have over the disease is the fact that if you have
identical twins, with the exact same genes, even if one gets
Alzheimer's the other usually does not.
So, we have to think about all the other
contributing factors beyond just genetics.
In my video on pesticides and cancer, I talked about this study.
There’s a list of chlorinated pesticides, including DDE
(a metabolite of DDT) that are classified by the EPA
as probable human carcinogens.
But in the study, blood levels of DDE and others were
associated not with increased cancer mortality,
but increased risk of other-cause mortality.
This led researchers to speculate it may be due to
an associated increased risk of diabetes or dementia.
I’ve talked previously about the diabetes link.
What about dementia?
“Elevated Serum Pesticide Levels and Risk for Alzheimer Disease.”
A research team at Rutgers found significantly higher blood
levels of DDE in Alzheimer’s disease patients compared to controls,
and autopsy studies show blood levels
are a good proxy for brain levels.
Those with the highest levels were at about four times
the odds of being demented with Alzheimer's.
And in a petri dish, DDE increases amyloid precursor protein levels
in human brain cells, providing a potential mechanism.
Here are the levels of the sticky protein implicated in the
development of Alzheimer's disease before and after some DDE
is added, at the levels one finds circulating in highly exposed
individuals in the general population.
Put all these studies together, and there does indeed seem
to be a link, consistent with data showing about a doubling
of risk for developing dementia among
those acutely pesticide poisoned.
Among U.S. elders, DDT and its breakdown product DDE are also
associated with increased risk of cognitive decline in general.
DDT was extensively used in the United States
from the 1940s through the 1960s.
At its peak, we were churning out 180 million pounds a year.
And it’s still in our bodies to this day,
contaminating the bloodstreams of more than 90 percent of Americans,
and DDE, the pesticide linked to quadrupling the odds
of Alzheimer’s, were at the highest levels.
It’s still in our bodies because it’s still in the food supply.
In my last video on the topic, I noted that the levels of
DDT, DDE, and other banned pesticides and pollutants
were much lower in the breast milk from a vegetarian mother
compared to breast milk of her non-vegetarian sister.
And the largest difference was noted for DDE,
which was four times lower in the vegetarian sister.
This is what you see across the board for these kinds of pollutants.
Food samples were collected from supermarkets across the U.S.
Here’s what they found for dioxins and PCBs
in beef, chicken, pork, processed meat, eggs, fish,
all plant-foods put together, and dairy products.
These toxins build up the food chain; so, it makes sense that
the most contaminated foods are meat, fish, and dairy products.
5 to 10 times higher levels in meat, eggs,
fish, and dairy than what they found in plant foods.
And unfortunately, cooking doesn’t destroy pollutants like DDE—
in fact it may make them even more concentrated.
And this is for a pesticide that may increase the risk
of Alzheimer’s disease as much as if you carried
the so-called Alzheimer’s gene APOE e4.