you know that was virtual field when I
first was following it back in I guess
the early 2000s you know I was a very
skeptical that there would be any effect
in humans taking reservatrol because
certainly not from drinking a glass of
wine but from supplementing just because
it seemed as though like the dose is
required to get some really beneficial
effects at least in some of the Rhoden
studies seem sort of you know high and
it wasn't it didn't seem very attainable
but as you know this there was a really
sort of compelling primary study in
rhesus rhesus monkeys I forgot when that
was published it was like mid 2000s or
2011 or something right rough photo
covers group at NIH yes that's right
they they gave these rhesus monkeys
resveratrol and I think they started out
with the lowered it was like 80
milligrams particularly when they went
up to like 480 any reason do you know
why they start with I've seen more than
one study do that yeah so I just
anecdotally what Rafa told me I think is
that they started at the low dose and
didn't see a change in pulse wave
velocity in the blood vessels so they
upped it and then that's what they sort
of benefit oh okay
so well this study was you know the the
the doses were very doable in humans
when you you know convert and and
basically they you know feeding these
monkeys they were feeding him like this
terrible high high sucrose diet hyster
gross and high-fat and they like it
caused them to have like forty percent
increased a or tech stiffness but the
resveratrol completely ameliorated a
like yeah so i was like holy crap that's
pretty cool yeah i think that was the
one study that sort of changed my view
and then i started to sort of get into
the literature and read ones that there
was you know there's been a variety of
clinical studies as you know and yeah
well I'm glad somebody's reading the
literature because that there was there
was a hate me Club with resveratrol
because it got so much attention there
is anything that gets a lot of attention
gets to hate me Club right in Reverse
but resveratrol I still take whereas
we're all probably a gram or so they
were gram
really yeah in my yogurt
I don't measure it out I just shake it
in so it might be half a gram to a
grants from your own like - it's like a
stash in the basement I privately - it
is I'm not as ethically fine doses of
resveratrol above 250 milligrams yeah
right you made a good point which is
it's a really insoluble molecule and
that's one of the well there are two
problems with resveratrol one is it's
really insoluble so if you just give it
as a dry powder to an animal or a human
it's less likely to get absorbed we know
that as a fact include it with a bit of
fat it'll go up 5 to 10 fold in the
bloodstream really big effect we've seen
in mice and monkeys it was with a bit of
fat in the diet as well
I mean the second problem with
resveratrol is that it's light-sensitive
and so those people who researchers who
put it in a plate with worms or didn't
treat the molecule with respect it goes
Brown it goes off that's one of the
reasons it's very hard to put in a
cosmetic because you cause medical turn
brown if you use brown or resveratrol it
won't work so you've got to keep it in
the dark in the cold and it'll be fine
okay so so we're in a basement cold dark
and also I think there's various forms
like trans-resveratrol I go for the
trends because when we gave the SIS form
to this or to an enzyme it didn't
activate it but the trans worked
brilliantly yeah Rafa de Cobo actually
he's been a good friend over the years a
great colleague he did the study with us
on the mouse or his virtual study that
showed that on a high-fat diet those
mice were extremely healthy and
longer-lived and their organs when we
they opened up the mice they were
pristine so that the mice was still
obese because we didn't give him a lot
of resveratrol is pretty low dose but
their organs were so beautiful their
arteries when you stained them for oil
of fat it was night and day the ones on
resveratrol all the ones without
reversal was staying with fatty lumps
reversal clean and that alone makes me
say you know resveratrol is probably not
going to hurt me
and it may very well help my
cardiovascular system seems to be really
important for a cardiovascular system
and I'm just kind of want to know why
why is it we we have a number of ideas
and whereas very troll is a dirty
molecule so there's not just one way it
works sirtuins definitely are involved
we now have a mouse that's mutant for
the resveratrol activation of certain
one so we now see that some some aspects
like endurance of resveratrol seem to be
through sir one so one of the effects is
through certain ones anti-inflammatory
actions in the lining of the blood
vessels the endothelial cells yeah that
seems to be important and there's other
aspects also in DNA repair as well um
infiltration of macrophages in there
seems to be dampened and we also looked
at oxidative stress in those arteries of
those mice treated and it was way down
in there is very tall nice yeah with the
rhesus monkeys with the free now
basically like you know completely
reversing that forty percent a or t'k
stiffness that's like pretty it's pretty
dramatic effect it isn't and so yeah I
think resveratrol it's people are you
know always a true is it not at 60
minutes did a story and then there was
an argument about how it was working and
so people are confused about the
molecule night I still stand by it
because the results like you say in
animals and in there are clinical
studies now lists that are really
positive in humans not all of them
sometimes it has no effect those one
study where it interfered with endurance
exercise don't understand that but
Foreman was kind of shown to do
something similar where I prevented
mitochondrial applications yeah I mean
maybe Rhonda was maybe happening is that
if you're dampening antioxidant in free
radicals too much you're actually losing
that kinetic effect exactly the might of
Rome Isis but but I haven't seen any
downside I'm you know I'm I'm the N of
one in as you would say in a clinical
trial I've had my heart checked out with
a 3d movie MRI my heart looks like it's
20 it's got no sign of aging so it's
doesn't seem to be doing myself and my
dad any harm so how long have you been
taking it how do you since 2003 Wow can
you take a battleground give her so yeah
okay
you