Alright, “systemic lupus erythematosus,” k we totally got this.
“Systemic” is easy, and refers to affecting multiple organs in the body.
“Erythematosus” means reddening of the skin, alright alright.
“Lupus” is latin for “wolf”.
So affects multiple organs wolf...reddening of the skin?
Not exactly, the modern use of lupus usually refers to a variety of diseases that affect
the skin...which was possibly originally used since these diseases resemble a wolf bite
on the patients’ skin.
Is that true?
Who knows.
At any rate, systemic lupus erythematosus, or SLE, sometimes just lupus, is a disease
that’s systemic, and affects a wide variety of organs, but notably often causes red lesions
on the skin.
But how does lupus affect all these organs?
Well usually the immune system protects the body’s tissues from invaders, but lupus
is an autoimmune disease, which means that immune cells start attacking the very tissues
their supposed to protect.
With lupus, essentially any tissue or organ can be targeted.
And just like a ton of other autoimmune diseases though, it’s not completely clear why it
develops, and like most diseases it’s the result of both genetics and the environment.
Alright so let’s go over a specific scenario to show how this plays out.
Let’s say this guy has susceptibility genes—genes that make him susceptible to getting lupus,
and he’s exposed to UV radiation in sunlight, which we know is an environmental risk factor
for lupus.
Well, given enough UV rays, think like sunburn, the cell’s DNA can become so badly damaged,
that the cell undergoes programmed cell death, or apoptosis, and it dies.
This produces all these little apoptotic bodies, and exposes the insides of the cell, including
parts of the nucleus, like DNA, histones, and other proteins, to the rest of the body.
Well those susceptibility genes specifically have an effect on this person’s immune system
such that their immune cells are more likely to think that these are foreign, or antigens,
and since they’re from the nucleus, we call them nuclear antigens, and immune cells try
to attack them.
Not only that though, susceptibility genes also cause this person to have less effective
clearance, essentially they aren’t as good at getting rid of the apoptotic bodies and
so they end up having more nuclear antigens floating around.
This means that B cells might swing by, see them, and start the production of antibodies
against these pieces of nucleus, which are called antinuclear antibodies, and these guys
are present in almost all cases of lupus.
Alright so those antinuclear antibodies bind to the nuclear antigens, forming antigen-antibody
complexes.
These complexes can get into the blood and then drift away and deposit or stick to the
vessel wall in all sorts of different organs and tissues like the kidneys, skin, joints,
heart.
Deposited complexes then initiate a local inflammatory reaction, which causes damage
through the activation of the complement system, which, after a huge cascade of enzyme activation,
leaves cell membranes with channels that let fluid and molecules go in and out all willy
nilly, causing the cell to burst and die, usually though you’d want this to happen
to foreign cell or an infected cell, not healthy cells.
When tissues become damaged as a result of these immune complexes, it’s known as a
type III hypersensitivity reaction.
UV radiation isn’t the only way to damage cells, though, right?
It therefore isn’t the only trigger that’s thought to be associated with lupus—other
potential triggers that have been associated with SLE include cigarette smoking, viruses,
bacteria, use of certain medications like procainamide, hydralazine, and isoniazid,
as well as sex hormones, particularly estrogen, which might be partly why lupus is more common
in women, especially considering it’s about 10 times more common in women than men during
reproductive years, but only about 2 or 3 times more common in childhood or past the
age of 65.
Okay okay, as a quick recap, the model that’s generally thought to be what leads to SLE
starts with some environmental trigger, which damages cells, and causes apoptosis and the
release of nuclear antigens.
At this point, the genetic components come in, and the person likely has certain genes
that make them not so good at clearing these apoptotic bodies and nuclear antigens, so
you end up with a lot of nuclear antigens floating around.
In combination, they probably also have genes that cause their immune cells to recognize
these nuclear antigens as foreign, which initiates an immune response, creates antinuclear antibodies
that bind to antigens and then float around and deposit in various tissues, which causes
inflammation.
These deposits and inflammation seem to be the cause of most of the symptoms of lupus,
which remember is a type III hypersensitivity reaction.
Many patients, though, also develop antibodies targeting other cells like red and white blood
cells, and molecules like various phospholipids, which can mark them for phagocytosis and destruction,
leading to additional symptoms.
This is considered a type II hypersensitivity reaction, although it isn’t fully understood
why some of these antibodies targeting specific cells and molecules develop.
So the classic presentation of lupus is fever, joint pain, and a rash in a woman of childbearing
age, but the actual diagnosis is difficult because it can affect a variety of people
of different genders and ages, and there’re also a wide variety of symptoms.
There are general symptoms like fever and weight loss, as well as specific symptoms
depending on the specific organ system being affected and damaged.
In fact, it’s so unpredictable that a diagnosis is given only when 4 or more out of eleven
diagnostic criteria are met.
The first few have to do with the skin and often happen to sun-exposed areas; the first
is a Malar rash, meaning a rash over the cheeks that spares the nasolabial folds, sometimes
just called a “butterfly rash” and this appears after sun exposure.
Second is a discoid rash, which is chronic rash in sun-exposed areas that are plaque-like
or forms a sort of patchy redness and can scar.
Finally, a general photosensitivity of the skin—essentially a catch-all category for
other rashes that happen to sun-exposed areas—typically only lasting a couple of days.
Another type of tissue that can be damaged is the mucosa, or the the inner membrane of
various tissues can become damaged as well, so the fourth criteria is ulcers in the mucus
membrane of the mouth or the nose.
Lupus can also affect the serosa, which is like the outer membrane of an organ or tissue,
so if it gets inflamed, people get get serositis, which could manifest as something like pleuritis,
which is inflammation of the lining around the lungs and chest cavity, or as pericarditis,
inflammation of the lining of the heart.
Although this isn’t strictly a criteria, it’s worth noting that lupus can affect
any layer of the heart—meaning in addition to inflammation of the pericardium, they might
also have inflammation of the endocardium and myocardium, leading to endocarditis and
myocarditis, of which the former presents as Libman-Sacks endocarditis, where vegetations
form, which are essentially clumps of fibrin, a blood-clotting protein and immune cells,
around the mitral valve.
Next, if the joints get inflamed, patients may also develop arthritis, specifically two
or more joints to meet the criteria.
If the kidneys are affected, patients might develop renal disorders, like abnormal amounts
of urine protein or diffuse proliferative glomerulonephritis, inflammation of the glomeruli.
For reasons that aren’t completely understood, some autoantibodies that target receptors
in the brain have been implicated as well, and this can cause neurologic disorders like
seizures and psychosis.
Sort of along the same lines, patients can have autoantibodies against components of
the blood, causing various hematologic disorders, for example they’ll get anemia if red blood
cells are targeted, thrombocytopenia if platelets are targeted, and leukopenia if white blood
cells or immune cells are targeted.
That last one is really a mind-bender because it means that your immune system is attacking
your immune system.
Alright so the last two have to do with specific antibodies being found in the blood, the first
one being antinuclear antibody, which we already went through.
Now a large proportion of patients with lupus have these, meaning this test is very sensitive,
but this test isn’t very specific, since these are seen in other autoimmune diseases.
Finally, they can have some other self-directed antibody that isn’t antinuclear antibody,
which can be one of three types.
It could be anti-Smith, which is an antibody against small ribonucleoproteins, or it could
be anti-dsDNA which is against double stranded DNA and is often seen more during periods
of active disease.
These two are relatively specific for lupus.
A third type of antibody though is anti-phospholipid which is actually against proteins that are
bound to the phospholipids, and is less specific for lupus, meaning that it can pop up in other
situations.
There are three types of antiphospholipid antibodies - anticardiolipin, which can cause
a false-positive test for syphilis since anticardiolipin antibodies are also sometimes involved in
syphilis, the other two are lupus anticoagulant also known as lupus antibody, and anti-beta2
glycoprotein I. Sometimes, because of these, patients with lupus develop an antiphospholipid
syndrome, where the antiphospholipid antibodies cause a hypercoagulable state, meaning they’re
more prone to developing clots and having complications like deep vein thrombosis, hepatic
vein thrombosis, and stroke.
These patients often end up needing lifelong anticoagulation therapy.
So lupus is characterized by periods of flare-ups and periods of remittance, so treatment is
often aimed at preventing flares or limiting how severe they are when they do happen.
To help prevent flares, some patients may have to avoid sunlight exposure with hats
and long-sleeved clothes.
To reduce severity of flares, corticosteroids may be used to help limit the immune response,
and finally, if symptoms are really severe, certain immunosuppressive drugs might be used.