So with council with K2, there appears to be a role with calcium, a role with
insulin resistance, and a role with inflammation.
One of our recently released videos on K2 and artery calcification got a lot of
attention. It wasn't all the good count. I ended up saying I hope this wasn't too
confusing because I went around a couple of times. Bottom line was it was
confusing and I think it was too confusing so I'm gonna try to clear up a
couple of things in this video. Now in order to clear those up though, I think
we have to start getting into an issue... maybe a bigger issue of biology and that
is what we call pleiotropic roles. What our pleiotropic roles? We'll talk about them
in just a minute. But short version is it's multiple roles
from the same thing. Now let's go back and understand pleiotropics just a
little bit more. Pleiotropic, if you look it up on Google, producing or having
multiple effects. One of the key places that we see this in medicine is in
genetics. We have pleiotropic genes for example the Marfan's gene. It creates
long fingers of thin body, misshapen chest, mitral valve problems, joint
problems, eye problems... a lot of things that may seem to be unrelated. And until
you start going deeper now, we all see this. You don't have to be a physician or
a geneticist or any of that. You all see that see this when you take simple
medications even including over-the-counter medications. Let's go
back to something most of us have known. Many of us most of us have probably
taken a good old-fashioned Benadryl, an antihistamine. It's given for anti-nausea.
It's given for sleep. It's taken for anti-allergy medicine. Of course, that's the
most common use. It's also taken for itch in anti-itching. So again, multiple uses
for that antihistamine which and until you begin to understand things a little
bit better may seem unrelated. Well with drugs, we often call these pleiotropic
effects as "side effects." Now here's the other thing to think
about. As I said, these all... these different effects may seem unrelated
until you go a little bit deeper. For example, with Benadryl, what's sleep got
to do with anti-allergy and what's all that got to do with itching. All of that
basically has to do with the thing called histamine. And this is an
antihistamine. When it blocks histamine, it starts having all of these different
effects - pleomorphic effects. With that Marfan's gene...
Marfan's... the Marfan's gene changes the way the body makes connective tissue.
Well places where connective tissue is a big deal in terms of the shape of the
chest, how long fingers, our eyes, the aorta... which can kill Marfan patients at
age 30... mitral valve... all of those things have to do with the Marfan gene impact
on connective tissue. So we talked about pleiotropic.
$5 word to basically mean multiple uses or multiple roles. Let's talk for a
minute about the rest of this channel. This is not the first time we've
mentioned pleiotropics. For example, we've talked about pleiotropics with
statins multiple times. Remember most of the rest of the medical community
prescribes statins for impact on cholesterol. I don't usually... when I do
recommend use of statins it has to do more with the pleiotropic mechanism
or what other people might consider the "side effect"... the impact of statins on
cardiovascular inflammation. There's another place that I've mentioned a few
times but not that often unless you've gone into some of our cognitive decline
our Alzheimer's videos and it has to do with insulin. Insulin has significantly
pleiotropic effects. We talked about insulin all the time on this channel but it's
mostly the impact of insulin in the rest of the body. If you inject insulin into
the nose, it will go past the blood-brain barrier. And once
insulin goes past the blood-brain barrier and gets into the brain, it has a
whole different set of mechanisms. Most of them are revolving around the
hippocampus and the biological biochemical mechanisms of memory
formation. So again bios you can be a little bit complicated medicine can be
complicating but you know what we need to understand some of these things if
we're gonna do the best job for preventing heart attack stroke and
obviously cognitive decline. So back to heart attack and stroke and K2. So what
are some of these different mechanisms for K2? Well, first of all, K2 carboxylates
a couple of enzymes that are very important in several processes here. One
was that first enzyme that I that I mentioned in this maybe botched
presentation on artery calcification... MGP... matrix gla protein. The
other enzyme that K2 carboxylates is osteocalcin. Now we're starting to get
a little bit technical here. I'm gonna jump back up to about 30,000 feet and
say, "Look, you see it in two or three places here. It activates those enzymes."
Those enzymes we know have a lot to do with calcification of the bone and
calcification of other tissue like plaque. Look at the bottom line. The
bottom line here: they also impact plasma glucose and insulin sensitivity on the
way. There there's an impact on inflammation and women and it impacts
the markers that we've talked about multiple times again on this channel
involving inflammation. AMPK. PPAR alpha. So again
K2 has few more effects and impacts and roles than think we just don't
completely understand yet. So another way again of looking at it is that this is
vitamin K and this this involves both K1 and K2. It involves anti-
inflammatory effect, regulation of adipokine, lipid-lowering effect, calcium
effect, insulin sensitivity.. affect lots of impact. There. Lots of different roles.
And again if you've made it this far, I appreciate it. Thanks. So you've been
asking about it when's the CIMT access tour. Starting Anaheim LA September
28th David Meinz will be there with some with a CIMT tech. It's about 250
bucks for the whole afternoon plus the CIMT plus the reading on the CIMT.
If you have further interest, you can sign up at CardioRisk.US/HealthyLife.