NMN Supplements. Could they be a solution to our aging problems? Are NMN supplements
the beginnings to find the fountain of youth. What defines aging anyway
and how do these supplements play a role to delay the aging process? Because who
wouldn't want to stay younger for longer. And as the global NMN market is projected
to reach $386 million by the end of 2027. Could researchers be on to something we don't know.
In this video, we will look at why nmn has been studied for anti aging,
the problems and hurdles that it faces, and how much of it do we know is safe to take?
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then consider subscribing as well. Now without wasting any more time, let's dive right in.
If you wanted to make a trillion dollars. This is the problem you would have to solve. You
would have to first control epigenetic shifts to control the on and off gene switches making
sure the good ones are on and the bad ones are off, secondly create genomic stability
instead of genomic instability which causes mutations, optimize nutrient sensing ability,
preserve telomere attrition and stop its shortening, prevent mitochondrial dysfunction,
let cellular senescence do its thing without harm, delay stem cell exhaustion, and improve
intercellular communication. You do all that, and you may have pretty much found the fountain
of youth. But wait a minute, Are you saying NMN can do that? Not so fast, we need a closer look.
To understand the hype around NMN, you have to first start with NAD. NAD is a molecule
that acts as a coenzyme in a lot of different processes in the body. Energy, DNA repair,and
what are known as sirtuins. Which are the enzymes involved in aging in the first place. In fact,
our NAD levels decline as we age, By middle age, our NAD+ levels have plummeted to half that of our
youth. But why does that matter? Well it turns out lower NAD levels can be responsible for many age
related conditions like cardiovascular diseases as well as neurodegenerative diseases which are
typically hallmarks of aging. So the goal is to use NMN to Boost levels of NAD, so that we dont
end up with age related disease, and potentially live a lot longer as a consequence. And if you
know a thing or two already about NMN, youve probably heard of NR as well. NR is also another
intermediate like NMN to make NAD. They basically dance together to create NAD. Which I can discuss
in another video if youd like. But with NMN, its interesting, people forget that its found in
foods, like avocados, broccoli, cabbage, edamame, and cucumbers. So just because it was removed on
Amazon for not being a legal dietary ingredient, because of its use cases as potential medicine,
you can still get it in foods since in mammals, NMN is synthesized from vitamin B3 in the
form of nicotinamide via the nicotinamide phosphoribosyltransferase (NAMPT) pathway,
which is your essential rate-limiting enzyme that catalyzes the conversion from nicotinamide
to NMN. Just maybe not in the amounts youd like, which well get into in a bit. But before we do,
lets dive into the problems that get in the way of making NMN supplements the
breakthrough many hope they would see one day to revolutionize the way we see aging.
The first problem is: most of our research is done on non human subjects. A lot of the
benefits surrounding NMN are seen to occur mostly in yeast, worms, and mice by looking at their Sir2
endpoints, NAD levels, and age related diabetes endpoints. And of course what works on animals,
doesnt always translate the same way on humans. Clinical trials on NMN supplementation in humans
have only begun in the last few years with the first one in 2019, by first examining its safety,
but you see the problem, only 10 people were involved in the study,
all were healthy Japanese men. That's how new this research really is.
The second problem is: How can you really tell if NMN supplements even work? In other words, how do
you measure anti aging in humans appropriately? Is that even possible? And I think this is one of the
biggest hurdles with supplements in this niche. And if you were to ask me where to start? Well,
I would start with the leading cause of death globally, it only makes sense,
which is cardiovascular disease. Do we have any research on how NMN impacts our cardiovascular
health, well, the closest thing I found was this: A 12-week randomized, double-blind,
placebo-controlled trial with 36 healthy middle-aged participants who received one
capsule of either 125 mg NMN or placebo twice a day.The study showed that the brachial-ankle
pulse wave velocity or the baPWV was used to evaluate blood flow and arterial stiffness,
respectively. And that There were no characteristic clinical findings in the
blood pressure, number of blood cells, and ABI values in both groups and that no significant
difference was observed in the average baPWV values between the two groups and “although NMN
supplementation improves age-associated vascular dysfunction in mice, its effects on human vascular
function have not yet been validated.” It would be fascinating to have another study on this though.
But aren't there any other parameters in which you can measure aging, surely arterial stiffness
and cardiovascular outcomes cant be the only ones, by far one of the best studies that
look at multiple endpoints is this one here done last year, which was the double-blind, parallel,
randomized controlled clinical trial done on 66 participants. In which blood cellular NAD
was measured, to have increased after 2 months of duration, next: a 6 minute walking endurance
test, which unfortunately wasn't found to be statistically significant, then it was the SF-36,
which is a wellbeing score, which was double that of the placebo, which is good to see,
next was the blood pressure endpoint: which wasnt statistically significant, and lastly,
what is known as HOMA. Which checks the insulin sensitivity of the cells. Because as we age,
we become less sensitive to insulin, and that brings on a lot of trouble down the road. And
again, between the two groups, findings were not found to be statistically significant.
So what did they get out of all this, in the end: the two endpoints they got were
the increase in NAD+/NADH levels in serum and the improvement in overall health and
walking endurance, which were clinically significant. Which to me is still great
because it opens up new horizons for further research. And remember, this is an ongoing
investigation. So its going to be interesting to see where we are 10 years down the road.
Now, you might be thinking, what about Dr. David Sinclair research, who is a professor at Harvard
University, who has studied this for decades, as well as the role of sirtuins in aging. His book on
lifespan, actually is what made this subject so popular. What if I want to see how NMN works on
me? How much to take? Now, you might have heard that Sinclair takes 1,000 mg of NMN in one dose
in the morning. To me, this may be too much. But 250 mg of NMN per day would also suffice too. 250
to 500 mg per day could be ideal since thats what the japanese study looked at. Always talk to your
primary care doctor before starting out any new supplement to see if its right for you. Because
for the most part they are tolerated just fine, but when taken at high levels – you can experience
nausea, diarrhea, flushing, stomach discomfort and indigestion. And many people who take them, do say
they feel sharper and have better concentration when they are on it. So thats interesting to see.
Let me know what your thoughts are down below. What do you think of NMN or NR.
I'm more curious to hear from you. Click the subscribe button if you
found any value in this video. And until then guys, ill see you on the next one.