Hello this is Dr. Ford Brewer with Prez Med prevention of heart attack
stroke and disability. In fact why don't you prevent all those diseases and have
a long healthy life? That's exactly what we're talking about tonight -
the science of anti aging. Iit has something to do with the resveratrol.
Remember people talking about that chemical in the skin of red grapes? .
If you're going to drink wine you should drink with red wine because it has
resveratrol? Well here's the fellow that discovered that. His name is David
Sinclair. He's tenured faculty at Harvard. Born in in Australia, educated at
University of New South Wales, came to the US to get further a PhD at Harvard,
and then do some postdoc work in aging of yeast.
Now why aging of yeast? We'll talk about that in just a minute. This is
to help set us up for that discussion. Now if you look at all of the chronic
diseases - the killer diseases of mankind: heart disease cancer diabetes
chronic lung disease all these diseases actually don't start early in life. They start
increasing dramatically in middle-age. The anti-aging researchers have noticed
this the folks at with the TAME study the gerontologists of the world all
noticed the same thing. It's not any one disease that's killing us. It's all of
them. There's something going on. It's coming to all of our body cells. So this is
happening at a cellular level. We're getting some breakdown so again back to
Dr. Sinclair he's again working on metabolism of the cells in relation to
aging. As I said he trained at Harvard, did some
post-grad at MIT looking at yeast aging he discovered a thing called sirtuins.
We'll talk about those in a minute. He also discovered that NAD+
nicotinamide. We'll remember where that is in just a minute - these things
are very important in terms of aging. The sirtuins have to do with enzymes that cut
off - they control the expression of other enzymes which have to do with - guess what / -
metabolism. In March of this year Dr. Sinclair and his team discovered NMN
it's related to resveratrol. In fact it's supposed to be a much better form
of resveratrol. It's an NAD+ precursor and booster. He'll
take it to clinical trials within six months. He'll be doing a trial on
another anti-aging drug remember the last thing we talked about was
old-fashioned metformin? Now let's go back to resveratrol - what does it do? This
is something - (a chemical) in the red skin of the grapes. When it goes to the cell
membrane it impacts a certain one - one of the seven sirtuins. We'll talk about this
in a minute and that in turn boosts the mitochondria. These are the
the powerhouse of the cell. Let's go back and ask a quick question
why didn't resveratrol work? or did it? Why are we not hearing about resveratrol
that much anymore? Wt's well here's why. In order to get enough impact from
resveratrol through red wine you'd have to drink a hundred cups a day
I'm sure that's a great setup for a joke! I'm sure a lot of people would
would want to volunteer! But again - totally impractical.So let's go let's
move ahead. What are situins? They are SIRTS they have 1 through 7. The yeast cert
that Dr. Sinclair discovered in his postdoc work in MIT was SIRT 1
SIRT 2 is the analog the humans have. It's the same thing - but it's slightly
different it stimulates AUTOPHAGY. SIRT tstands for Silent Information
Regulation - that doesn't tell us that a lot. But again what it does you don't
really see the the enzyme itself so much as its repressive or stimulating other
enzymes being transcribed and developed genetically it stimulates autophagy. -
you know think fasting when we fast we get an increase of the SIRTS and autophagy
You might remember (probably don't you might remember) it that's where the cell
starts taking up trash - old used up proteins that aren't that aren't
being used anymore - and burning it for energy so it burns old parts worn out
parts of the cell for energy. it inhibits inflammation. I want to go through
how it does that. But again inflammation is being found to be one of
the key components of aging along with our metabolic - our cell respiration. How
we get -how our cells get energy. This is an epigenetic process. That means It doesn't
change the genes themselves. But it changes the spools that the genes are
wound up on and results in down - regulation of some of the inflammatory
processes. Resveratrol, by the way, activates certain one but again as we
you just can't get enough of it for it to be very helpful. A quick spoiler warning
just maybe 30 seconds for the biochemical nerds in the group - remember
that this is the mitochondria? You remember it's the powerhouse of the cell
and you remember there are three major components of our metabolic process? . The
first component - glycolysis is used by yeast and cancer cells that's why they
do a low glycemic or low low carb diet for cancer for a lot of cancer patients
it only gets 2 the equivalent of what we call 2 ATP out of a glucose molecule.
Then we have the TCA cycle or Krebs cycle again another 2 - it's the
electron transport which requires oxygen. That's why we need oxygen to breathe. It
gets 34 out of the bunch now why did I go through all that? Because of NAD -
nicotinamide dehydrogenase. That's the chemical that we're talking about -
that we're boosting with NMN. This is another view of that. Thank you for
your patience if you were bored with the biochemistry part! Let's go back now and
just see if we can connect a few dots if you as you see from this headline high
glucose this is a very academic article. That I found while I was doing some
research on this. The time is interesting to read. When you start looking at this
and some of the other videos that we've done recently high glucose induced
alteration of SIRTS in endothelial cells causes rapid aging in p300 and FOXO
regulated pathway so high glucose remember we're also looking at glucose
in a couple of other places - like Valter Longo -
where he's looking to decrease diabetes through intermittent fasting (or fasting mimicking) and of
course Dr. NIR Barzilai's research where he is using metformin. Endothelial
inflammation. Endothelial inflammation is a big deal for us just on
a working basis right here in our clinic where we're decreasing heart attack and
stroke risk. Just a reminder on these two I've got another video where I talk
about Valter Longo and intermittent fasting the product that's called
PROLON - and one of the major impacts of PROLON is to increase that FOXO pathway. So
again you're starting to see we're connecting a lot of dots in terms of
research and anti-aging and in the past few years and they tend to focus on the
mitochondria as the powerhouse of the cell cell respiration - or the way this
cell gets energy for the body. Thank you!