MDRS or Morphologically-Directed Raman Spectroscopy is a measurement technique
which combines automated, high-resolution particle imaging with Raman microscopy
in a single integrated platform, automating the whole particle
characterization process to provide fast controlled measurement of component
specific particle size and shape distributions.
This new approach allows rapid differentiation of the individual components in a mixture
and because MDRS is an integrated, highly connected process you can see all your data
together joined up at a glance
This uniquely fresh approach to traditional analysis is incredibly useful
and unlocks all sorts of applications
So who uses MDRS?
MDRS is used to dramatically reduce the overall time and cost
of bringing new generic drug products to market
by simplifying the deformulation of the target product
and by proving in vitro bioequivalence of the generic product
compared to its reference listed drug,
reducing the need for clinical trials.
Other examples of MDRS successes are in the cement
and battery industries, where it plays a major role in developing
formulations with lower environmental impacts.
in addition it can be used to identify counterfeit drugs and help trace their source.
Because MDRS is a fully integrated, automated process, it is much easier to use than manual microscopy
or typical Raman microscopy systems.
Its ability to analyze thousands of particles unattended substantially reduces risk
by ensuring decisions are made based on data representative of the whole sample
Let's take a deeper dive and see how it works.
The workflow conveniently divides into three stages.
The first stage is the controlled dispersion of the sample.
Everything is now ready for the second stage, Static Imaging,
where you automatically measure the particle size, together with an array of shape parameters.
The third stage of MDRS is when particles of interest,
defined based on particle size or shape classifications,
are targeted for chemical identification using Raman spectroscopy.
Once the particle identities are confirmed,
particle size and shape distributions for individual components can be generated.
By targeting use of Raman spectroscopy,
component specific size and shaped results are delivered in a fraction of the time
compared with traditionally separate microscopy and Raman spectroscopy methods.
This way a much more representative sample of material can be measured.
Summing up,
MDRS provides a single connected process.
A new better way to identify one or more individual component's morphological and chemical profiles,
within a multi component mixture, which at a glance can rapidly
and easily be compared across samples.
What problems can MDRS solve?
MDRS analysis provides answers to critical questions, such as 'What does my sample consist of?',
'Is my sample contaminated and with what?',
'Has a change in my process caused a physical change in my product?',
'Is my product physicochemically identical to the reference product?'.
So what have we learned?
MDRS is a powerful analytical technique, enabling the rapid automated characterization of
individual components within a multi-component sample.
With results presented in an intuitive easy to grasp way.
You can harness this power by using Malvern Panalytical's Morphologi 4-ID.
Morphology 4-ID enables users across a wide range of fields to discover more about their samples
and develop a deeper understanding of their processes.
The Morphologi 4-ID dramatically reduces operator time and effort
by offering automated and accurate measurement of particle size and shape distributions,
as well as chemical identity.
If you're looking for unassisted, seamless operation,
a substantially faster workflow and greater traceability and control,
then think Morphologi 4-ID
from Malvern Panalytical,
the world leader in materials and biophysical characterization technologies
Clarity by Design
To find out more please visit:
www.MalvernPanalytical.com/MDRS