>> Larry: LARRY SPRUILL, LOCAL
4.
>> Kim: ALL RIGHT, LARRY.
>>> WE CONTINUE TO HEAR ABOUT
THE IMPORTANCE OF DEVELOPING
WIDESPREAD ANTI-BODY TESTING AS
WE MOVE THROUGH THE CORONAVIRUS
VIRUS.
>> Devin: LIKE SO MANY THINGS,
IT IS VERY CHALLENGING.
DR. McGEORGE GOING TO NEW
LENGTHS TO EXPLAIN EXACTLY WHAT
ANTIBODIES ARE AND WHY
DEVELOPING A TEST FOR THEM IS SO
COMPLICATED.
FRANK, I’VE BEEN LOOKING FORWARD
TO THIS STORY ALL DAY.
>> Dr. McGeorge: I’M GLAD, KIM AND DEVIN.
AND DEVIN.
I GOT CREATIVE IN TERMS OF
CLAYMATION CREATIVE.
ONCE I EXPLAIN IT, I’LL THEN
EXPLAIN WHY WE WANT TO MEASURE
THEM AND THE DIFFICULTY IN DOING
IT.
THESE ARE VIRUSES INVADING THE
BODY.
ALL VIRUSES ARE COVERING WITH
PROTEINS WITH DIFFERENT SHAPES
AND FUNCTIONS.
SOME SHAPES ARE CRITICAL TO
MAKING IT DANGEROUS.
OTHERS LESS ESSENTIAL.
THIS WILL BE IMPORTANT LATER.
THE FIRST TIME YOUR BODY IS
INFECTED BY A VIRUS YOU’VE NEVER
BEEN EXPOSED TO BEFORE, YOU
DON’T HAVE ANY ANTIBODIES TO
DEFEND YOURSELF. LUCKILY, THERE ARE OTHER WAYS
LUCKILY, THERE ARE OTHER WAYS
THAT YOUR IMMUNE SYSTEM FIGHTS
INVADERS UNTIL THE ANTI-BODY
MAKING SELLS GET TO WORK.
THE ANTIBODIES ARE "Y" SHAPED AND THEY GRIP ON TO A VIRUS.
AND THEY GRIP ON TO A VIRUS.
THE SURFACE PROTEINS ARE CALLED
ANTIGENS.
THE ANTIBODIES YOU MAKE ARE
DIRECTED AT THESE DIFFERENT
SHAPED ANTIGENS.
SOME GO AFTER A POINTY ONE, THE
OTHERS A ROUNDED ONE AND SO ON.
BECAUSE SOME OF THE ANTIGENS ON
THE SURFACE OF A VIRUS ARE
NECESSARY FOR THE VIRUS TO REMAIN HARMFUL, WHEN AN
REMAIN HARMFUL, WHEN AN
ANTI-BODY GRABS THEM, IT CAN NEUTRALIZE THEM.
NEUTRALIZE THEM.
AND THEY’RE THE BED -- BEST
ANTIBODIES.
THEY MARK IT FOR DESTRUCTION.
ONCE YOU MAKE ANTIBODIES AGAINST
A SPECIFIC ANTIGEN, YOUR BODY
KEEPS THEM CIRCULATING AROUND IN
CASE THAT VIRUS SHOWS UP AGAIN. THEY KEEP A RECORD TO MAKE MORE
THEY KEEP A RECORD TO MAKE MORE
OF THEM FASTER THE NEXT TIME
AROUND.
SO A COUPLE OF THINGS TO
REMEMBER.
WHEN YOU MAKE ANTIBODIES,
THEY’RE DIRECTED AT SPECIFIC
PARTS OF THE VIRUS, NOT THE
ENTIRE VIRUS. AND NOT ALL ANTIBODIES ARE EQUAL
AND NOT ALL ANTIBODIES ARE EQUAL
IN STRENGTH GAENAGAINST AN INVAD
IF YOU HAVE ANTIBODIES, THAT
MEANS THEY’RE EXPOSED TO THEM.
THE ANTIBODIES ARE PROOF OF
THAT.
I WANT TO EXPLAIN WHY BUILDING A
TEST TO DETECT THE ANTIBODIES IS
NOT AS SIMPLE AS IT MIGHT SEEM.
>> Devin: A GREAT EXPLANATION
AND THE START OF YOUR HOLLYWOOD
RESUME FOR PRODUCTION WORK.
EXPLAIN A LITTLE BIT ABOUT YOUR
CREATIVE PROCESS ON THIS.
>> Dr. McGeorge: WELL, HERE’S
SOME BEHIND-THE-SCENES VIDEO YOU
MIGHT WANT TO LOOK AT.
I MADE LITTLE CLAY MODELS OF
EVERYTHING AND MOVED EACH MODEL
A TINY BIT FROM FRAME TO FRAME.
IT’S QUITE PAINS TAKING TO MOVE
THEM A HAIR AT A TIME AND
SHOOTING OVER 1300 FRAMES OF
VIDEO MANUALLY FOR FRANKLY 90
SECONDS OF TV, BUT I THINK IT
WAS WORTH IT FOR OUR VIEWERS.
>> Devin: WAS IT PLAYDOH OR WHAT
KIND OF CLAY WERE YOU USING?
>> Dr. McGeorge: YES, THIS WAS
CALLED SCOPY.
AND IT NEVER DRIES OUT, SLIGHTLY
OIL-BASED. >> Kim: I LOVE IT!
>> Kim: I LOVE IT!
AND I UNDERSTAND IT A LOT
BETTER, TOO.
>> Devin: MOST IMPORTANTLY.
>> Dr. McGeorge: THAT WAS THE
GOAL.
>> Devin: TIME FOR OUR DAILY