9 Warning Signs of Bone Marrow Cancer
Forming in white blood cells known as plasma cells, multiple myeloma causes cancer cells
to emerge in the bone marrow.
Over time, these cancerous cells begin to push out healthy plasma cells responsible
for fighting infections and producing the antibodies required to lead the fight against
germs and infection.
Instead, the cancerous cells produced by multiple myeloma result in the production of abnormal
proteins that eventually cause significant health problems for the afflicted — in particular,
kidney issues.
Because multiple myeloma targets healthy cells in the bone marrow, it’s often referred
to as bone marrow cancer.
As with any form of cancer, the key is being able to identify the signs and symptoms of
the illness and take action before it becomes too serious.
So, what exactly are the symptoms of multiple myeloma, often referred to as bone marrow
cancer?
1.
Exhaustion
One of the earliest signs of multiple myeloma is a general feeling of exhaustion that fails
to go away, even when one gets lots of rest and follows a healthy diet.
These feelings of fatigue are usually related to the way multiple myeloma attacks the healthy
cells of the bone marrow, which in many cases can result in anemia or inconsistent cytokine
production.
Because feelings of fatigue are fairly common, this symptom should be considered in combination
with other signs of multiple myeloma on this list.
For example, someone who has a family history of cancer, and especially bone marrow cancer,
will want to be tested for multiple myeloma if they suddenly experience a long, generally
unbreaking wave of exhaustion lasting several days or weeks.
2.
Anemia
Anemia, which occurs when the number of red blood cells reaches critically low levels,
results from multiple myeloma because it causes the suppression or crowding out of healthy
red blood cells.
The most common side effect of anemia is an overpowering feeling of fatigue that may not
break even with healthy diet, ample rest, fluids, or stimulants like caffeine.
This feeling of general exhaustion can last for days or even weeks at a time.
However, it should be noted that anemia is not only related to multiple myeloma and the
development of bone marrow cancer.
It can result from a number of other health conditions, from pregnancy to menstruation
and iron and vitamin deficiency.
Simply failing to get enough iron in the diet can cause anemia.
3.
Pain in the bones
One of the more obvious and distinct signs of multiple myeloma is feelings of pain in
the bones.
This is because multiple myeloma forms in the marrow of the bone and, as time goes on,
its suppression of healthy red blood cells can cause the bone to thin and weaken, resulting
in osteoporosis.
Once this stage is reached, the chance of fracturing or completely breaking the affected
bone increases substantially.
It also results in mild to moderate feelings of pain in and around the bone.
This pain may be more noticeable if the problem involves particularly critical bones, such
as the spine, which are responsible for supporting multiple parts of the body.
This pain tends to increase with movement and may be considerably more noticeable during
the evening and early morning hours.
If the spine is affected, the patient may experience compression fractures that cause
slumping; over time, this could even result in a patient losing a few inches from their
height.
4.
Numbness
Because multiple myeloma targets the healthy red blood cells of the bone marrow, in time
it can cause the patient’s bones to weaken.
While this often results in the affected bones becoming frailer and painful, it can also
lead to general feelings of numbness.
This sensation of numbness is most pronounced when multiple myeloma invades the vertebrae
of the spine.
As the problem spreads through the spine, it causes the bones to weaken, resulting in
vertebrae coming into contact with each other and the nerves spiraling around the spine.
In touching upon these highly sensitive nerves, multiple myeloma effectively scrambles the
signal traveling between the brain and spine, leaving the area feeling numb.
5.
Kidney problems
If not caught early on, multiple myeloma can eventually lead to significant problems in
the kidney.
This is because the development of multiple myeloma results in the emergence of proteins
that, when produced to excess — as they often are when multiple myeloma takes hold
— can put undue pressure on the kidneys, resulting in damage or even kidney failure.
Ideally, the patient would recognize other signs and symptoms of multiple myeloma — such
as excessive fatigue or bone pain — and be able to take action prior to reaching the
stage where kidney problems emerge.
However, should those signs not raise flags, the emergence of kidney-related issues should
be identified as a possible sign of multiple myeloma.
6.
Hypercalcemia
Over time, multiple myeloma results in the production of cancerous cells that effectively
push healthy cells out of the bone marrow.
This makes the bone feel weak, painful, and potentially numb.
In time, it could cause the bone to fracture or completely break.
This wearing down of the bones through multiple myeloma also results in a condition known
as hypercalcemia, which emerges when there is an excessive amount of calcium in the blood.
Hypercalcemia is often found in people with multiple myeloma, because their bones, which
contain calcium, are effectively breaking down.
Hypercalcemia introduces its own, rather significant health problems, from exhaustion to constipation
and kidney issues.
7.
Weight loss
Many people struggle with their weight, particularly if they are not physically active or if they
have unhealthy diets based on excessive consumption of carbohydrates, fats, and proteins.
In essence, most people will have a hard time losing weight unless they take demonstrable
steps to be more active and eat well.
But weight loss can occur rapidly if someone is struggling with multiple myeloma.
That’s because the condition leads to many symptoms that can suppress the appetite, from
exhaustion to excessive pain.
The condition can also make it difficult to exercise and burn calories, which tends to
help boost the metabolism and increase one’s appetite.
In short, if an individual has not changed their diet and is not excessively active,
but still manages to lose weight, there may be an underlying and significant health problem.
8.
Mental confusion
Feelings of general confusion can result from many of the symptoms associated with multiple
myeloma, including hypercalcemia and kidney damage.
In essence, as the body struggles with the breakdown of the bone marrow, it can send
confusing signals to the brain.
For this reason, mental confusion rarely emerges during the early stages of multiple myeloma,
when the body is still generally healthy.
Instead, feelings of confusion become far more evident later on, when the condition
has caused several serious side effects to emerge.
9.
Frequent illnesses
Multiple myeloma causes the breakdown of the bones by invading the bone marrow, where it
effectively crowds out healthy cells with cancerous cells.
Not only does this present serious problems for the patient in the way of bone decay,
it also reduces the number of healthy cells capable of helping fighting infections, such
as colds.
In time, then, multiple myeloma can weaken the patient’s immune system, making them
more susceptible to infections.
In effect, this can make the patient feel as though they’re constantly battling illnesses.
Not only that, but multiple myeloma can make it more difficult for the body to beat and
recover from infections, particularly those affecting the respiratory tract and lungs.