Oh hi! I hope you don't mind that I'm eating.
This is actually just my first course.
For my birthday, the writers wrote me a script
where I just get to eat!
The whole time!
And I can't think of a better way to demonstrate
the workings of the digestive system,
the series of hollow organs that we use to break down
and process the nutrients and energy we need to function.
Though...wait a second, if I remember correctly
digestion is actually pretty freaking disgusting...
so maybe I shouldn't be eating right now.
Oh whatever... Waiter!
The digestive system is so fundamental that it's basically
step number one in the guide: How to Make an Animal.
You probably remember that during the embryonic development of most
animals, the digestive tract is the very first thing that forms.
When the blastula, that little wad of cells that we all used to be,
turns into a little wad of cells with a tube running through it,
that tube is your digestive system.
And pretty much every animal has a digestive system of some kind,
but they're not all alike.
Far from it.
In fact, digestive tracts are specially adapted
to animals' feeding behavior and diet.
For instance, a house fly eats mostly liquid or very finely
granulated food, but before it does that,
it's got to puke its digestive juices all over its lunch
and then let them digest it for a while
before it sucks it up into its mouth.
If we did it like that, first dates would be...less common.
Most vertebrates put food in one end of the tube
and our digestive system processes it,
and then it gets rid of the waste out the other end of the tube.
No muss, no fuss.
Well, actually, there's a little bit of muss, at the end.
You may have noticed.
But the beauty of it is that this whole process is run by our
autonomic nervous system, so we don't have to think about it,
until maybe the very last step when we're in traffic
and just had two cups of coffee and a bran muffin...
then we have to think about it a little bit.
Among vertebrates, the digestive tract might be short or long,
or have organs that do different things
depending on what its feeding habits are.
For instance, dogs are mostly carnivores and also scavengers:
They mostly eat meat,
but sometimes that meat's been dead for a while.
So, the dog's digestive system has developed to take food in,
absorb as many nutrients as possible,
and then deposit it on somebody's lawn,
all in a period of about six hours.
Dogs have an extremely short digestive tract, because,
if you're in the habit of eating rotten meat,
you'd better be able to digest it fast.
If you don't, the bad bacteria that's probably living on that
armadillo carcass is going to take up residence in your gut
and put you in a world of hurt.
Cows, on the other hand, take a very very very long time
to digest their food, around 80 hours,
because they have to process plants, mostly grass.
Grass has a ton of cellulose in it, and evolution has yet
to produce an animal that can manufacture a stomach acid
or enzyme tough enough to break down cellulose.
So, cows have microorganisms in their guts
that break down the cellulose for them.
This process takes a four-chambered stomach
each one with a slightly different microecology
and a lot of cud-chewing,
or regurgitating and re-chewing of grass
before it passes all the way through.
So, nature is full of crazy digestion stories,
and I honestly wish that I had time to tell them all.
But let's focus on human digestion from now on, mostly because:
You're probably a human, we don't assume anything here,
and you'll be wanting to know how YOUR body does all this stuff.
And humans actually have a have a pretty good
all-purpose digestive system:
We're omnivores, after all, we eat plants AND meat
so our systems are generalized to handle all kinds of stuff.
Like most animals, humans have a bunch of different acids
and enzymes in our digestive tracts that break food down
so that it can be absorbed and used by our bodies.
But the secret to successful digestion
is maximizing surface area. In more that one way, actually.
The first way we maximize surface area is on the food itself.
Say I take a bite out of this apple.
Right now there's like, an apple boulder sitting there in my mouth.
I've got enzymes in my saliva that immediately start
breaking it down, like, the outsides of the boulder.
If I swallowed this chunk whole right now,
not only would it hurt like heck,
the rest of my digestive system would have a really hard time
dealing with it, because most of the enzymes and acids
would have the same difficulty working all the way
through this big solid hunk.
But, when I use my awesome teeth to chew up this hunk of apple
suddenly there's double, triple,
quadruple the surface area on the food!
I'm making up apple gravel from the apple boulder.
Maybe even apple sand.
For humans, chewing is key because breaking down our food into
smaller and smaller bits allows enzymes and acids to get at them.
And after our teeth have made the pieces small enough,
the chemicals break them down further until
they're fine enough for our bodies to absorb nutrients from them.
But it's not just the surface area of the food that's important,
the surface area of the digestive system
is key to the whole process as well.
Last time I talked about how we have a whole bunch
of surface area in our lungs to absorb tons of oxygen all at once.
Well, our digestive systems work in much the same way.
Most of the absorption of nutrients happens in our small intestines,
and the length of the average human adult's small intestine
is about 7 meters!
Plus, inside our small intestines
there are a bunch of little folds and little absorbing fibers
with absorbing fibers on them, and no I didn't mis-speak,
the fibers have fibers..
that's how hard our intestines work to increase their surface area.
Last episode I was all impressed that lungs had
a total surface area of 75 square meters...
well the small intestine has a surface area of 250 square meters!
Blegh... It's kind of gross.
I wouldn't want to see it spread out over a tennis court or anything
But I'm getting ahead of myself here.
Digestion does not start at the small intestine, people,
it starts at the mouth.
Now, as you can see, this hot pocket is surrounded
by some kind of bread, if you can call it that.
Bread is a starch, which breaks down into glucose.
When I start gnawing on a piece of bread,
because the outside here is mostly bread.
the glands in my mouth start secreting saliva,
which contains salivary amylase, an enzyme designed to break
down starch into glucose.
The more I chew, the more amylase will get to all the different
sides of the bread, and that's why the more you chew bread,
the sweeter it tastes.
Amylase doesn't really do much to the meat or the cheese
in this thing.
I've got other enzymes and acids that are going to work on them
later on in the system, but I am gonna chew all that stuff up
real good right now so that those other enzymes
can do their jobs later.
I'm gonna swallow all this.
So now the masticated hot pocket has passed down my pharynx,
or throat, and into my esophagus, which leads to my stomach.
There's actually this little cool flap of tissue
called the epiglottis that blocks the trachea when I swallow,
so that the food doesn't end up in my respiratory system.
This ball of food that I just swallowed
actually has a scientific name, it's called a bolus
and it rides a kind of wave of muscle action down the esophagus
into the stomach.
This wave-like contraction of the smooth muscles around the tube
of the esophagus is called peristalsis, and it's basically
how most of the movement in your digestive system is accomplished.
Now my hot pocket bolus is in my stomach now
which is where the food really starts getting manhandled.
The stomach basically takes a scorched earth
approach to digestion. It's not messing around.
It's like a churning cement mixer that can contract
and expand with these big,
accordion-like folds of muscle called rugae.
Your stomach's job is to turn everything over and over,
smooshing and mixing all the pieces up
with its cocktail of acids and enzymes called gastric juice.
Gastric juice is mainly made up of hydrochloric acid,
an enzyme called pepsin, and some mucus and water.
Hydrochloric acid has a Ph of about 1
which is strong enough that, if you got it on your hand,
it would give you a chemical burn.
So the acid breaks things down and hopefully kills
most of the bacteria that you might find on your food.
The pepsin starts breaking down proteins into amino acids.
Now, that mucus is important.
It's there to protect your stomach, so that it doesn't digest itself.
When you don't have enough of that mucus you get peptic ulcers,
which happen when your stomach lining
comes in direct contact with your stomach acid.
And the water's just in there to make everything all soupy,
because what you want by the time your food leaves your stomach
is chyme, which is a kind of liquidy slop that you might
be familiar with from the last time you had a stomach virus.
You knew this conversation was going to have to get
a little bit gross and I didn't want to bring diarrhea into it
too much because, you know, I've been eating.
But when something bad is going on in your digestive tract,
your body doesn't worry too much about absorbing nutrients,
it just wants to get the chyme out of there.
So, chyme is what you see when...
You get the picture.
Anyway, there's a little valve, or sphincter
between the stomach and the small intestine
that regulates how much chyme gets into the small intestine
and when it gets in there.
The very beginning of the small intestine is called the duodenum,
this is where a lot of the small intestine action happens,
by which I mean, lots of things get absorbed and also secreted,
like bicarbonate, which neutralizes the gastric acid
before it goes any further.
Now, the coolness of the small intestine can't be overstated.
It's ground zero for cellular exchange of nutrients
and the breakdown of fats.
And again, the reason it's so good at absorbing
is because of all the surface area it's got going on.
A lot of that surface area comes from the fact that,
despite its name, your small intestine is frickin' long:
in a human, it can range anywhere from 4.5 to 10.5 meters.
But that's not all!
The whole inside is lined with epithelial tissue
that has tons of ridges and folds in it.
Surface area to the max!
And on those ridges and folds are these little hair-like fibers
of flesh called villi.
Each villus has capillaries in it, so that it can absorb nutrients.
And get this: each villus, which is only like half a millimeter long
is covered in teeeny tiny little microvilli,
providing even more surface area!
In fact, apparently, the small intestine has a texture
kind of like velvet, which is...
[DISGUST]
Oh great, now I eat the milkshake? Fantastic. Okay.
So another thing the small intestine does,
with the help of its friend the gallbladder,
is break down fatty stuff, like this milkshake.
Near the top of your small intestine is a little pipe
where bile salts, manufactured by the liver
and stored by the gallbladder, are squirted out
into the small intestine.
Bile works like dish detergent on a pan
you just fried something in: it's an emulsifier.
It takes hydrophobic fat molecules and breaks them up
into fatty acids and monoglycerides,
which can be absorbed by all that epithelial tissue!
I've never had Chunky Monkey before
Mmmmm!
Nuts!
After your food passes through those yards and yards
of small intestine, the chyme goes through another sphincter
and enters the cecum, the beginning of the large intestine.
The large intestine's job is to remove most of the water
and bile salts from the chyme so you don't have constant diarrhea.
So, you can thank it for that!
It's called "large" because it's wider than the small intestine,
but it's not nearly as long:
it's basically just a one- and-a-half meter victory lap
around outside of the small intestine and then it calls it good
Also, I should mention, at the end of the cecum
there is a little tube where the the appendix comes in.
For a long time, we thought that the appendix was a worthless,
vestigial structure that we used to need at some point
in our evolution but didn't need anymore.
However, recent studies are finding that the purpose of the appendix
in modern humans is probably to act as a safe house
for all of the good bacteria you need to help you digest your food.
If you get a virus or food poisoning or something
and all your digestive systems say, "GET IT ALL OUT OF ME!"
The appendix has a little sample of your gut bacteria
that it spits out to help recolonize you after your illness.
So, I think you're familiar with the final step
in the digestive system.
That's the pooping.
Your food can spend as long as 3 days in your digestive tract,
and a lot of that time is spent in the large intestine,
mostly reabsorbing the excess water from the chyme
and prepping your poo for its great entrance into the world.
When it's done, it passes through everybody's favorite sphincters,
the anal sphincters.
There are two of them.
And, you know...out in the world to live its own life.
And that's the end of our little tale here
that begins with the hot pocket.
I hope you'll join us next time for more disgustingness,
as we discuss the details of the Excretory System!
Until then, bon appetit!
Thank you for watching this episode of Crash Course Biology.
If you want to go back and review anything.
Table of contents just click on it.
Thanks, of course, to everybody who helped put this episode together.
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And our team of experts will attempt to answer.
Goodbye.