hey what's up guys so in case you've been living under a rock for the past year there's this little
thing called tercestrone that has been taking the internet by storm lately however in certain
circles uh there's a list of things that you don't talk about and at the top of that list
is religion just below that is politics and then right below that is terkestrone
guess that's my guy i can take him no problem and this is largely because of how divisive
tercestrone has become lately in specific circles on one side of the aisle you have guys that
proclaim that they are vehemently opposed to the intake of terkestrom because there is no quote
any clinical data to support its uh consumption and then on the other side of the aisle you have
guys that claim that you can essentially get steroid-like results from taking tercastrone
however like most things in life the truth probably lies somewhere in between on one
hand it is true that the clinical data is extremely inconclusive at this moment however
from an anecdotal standpoint i have nothing but good things to say about ectosteroids
however like most things in life there is literally no such thing as a free lunch and
so essentially what i want to do in this video is walk through the possible side effects of
the some of the proposed mechanisms of action now it is important to note here that a lot of these
are going to be extremely loose connections um that are kind of uh conclusions from the proposed
mechanisms of action so there isn't a lot of hardcore clinical data here however i did want to
again dive into the mechanisms of action and kind of at least provide some proposed possible side
effects here now the primary proposed mechanisms of action that ectosteroids are getting a lot
of attention for is that they appear to be fairly potent estrogen receptor beta agonists as well as
g-protein-coupled receptor agonists now this is the primary mechanism by which ectosteroids cause
their theoretical anabolic effects and downstream of their activity at these two receptor sites
they also appear to activate the pi3k and akt pathways now the pi3k and the akt pathway
is the primary means by which um ectosteroids theoretically induce muscle protein synthesis
however it is important to note here that the research here is extremely preliminary and when
it comes to kind of proposing some possible side effects that might be associated with
this mechanism of action it is important to note that it is extremely difficult because there's not
um really that many even pharmaceuticals that are able to activate this pathway however if you do
take a deeper look into this metabolic pathway you will recognize that the pi3k and the akt pathway
is intricately involved in the immune response and inflammatory pathways now a lot of people don't
understand this however it is important to note that when you exercise one of the primary means
by which your body actually responds to exercise and able to induce adaptations to exercise and
induce muscle protein synthesis is actually via inducing states of inflammation and this is one
of the reasons why taking anti-inflammatories just before a workout or just after a workout has been
demonstrated to actually hinder the adaptation to exercise however theoretically by improving
the responsiveness of the inflammatory pathway to exercise there is a theoretical improvement to
the adaptations to that exercise now the possible side effects to actually keep in mind here are for
individuals that already have an overactive immune system so for individuals that have
autoimmune issues or maybe autoimmune issues run in your family this might be something to keep an
eye out for just if you start to notice symptoms of auto immunity issues and now i'm not saying
that this is a hundred percent possibility however this is just something that i am proposing that
may be an issue for some individuals that may be predisposed to inflammatory and immune issues
now the next mechanism of action that i want to talk about is the possible adaptogenic properties
of ectosteroids now again the research here is extremely preliminary however there are a couple
of different studies that do demonstrate that ectosteroids may possibly have some adaptogenic
properties to them now adaptogens are a class of herbal supplements that are typically used to
aid in the adaptation to stress and now they typically do this by either one suppressing
stress hormone signaling in the body or by two increasing levels of specific neurotransmitters
in the central nervous system now adaptogens are something that i do talk a lot about
in my complete guide to supplementation and so if you're interested in learning
more about adaptogens or pretty much any other supplement that you could possibly think of for
the use of improving specific health markers make sure to check out the description for a link to
that complete supplement guide now the adaptogenic properties of ectosteroids seem to be mediated by
their ability to simply increase the levels of some specific neurotransmitters namely
dopamine epinephrine and gaba now dopamine and epinephrine are some of your primary stimulatory
neurotransmitters and help kind of like to improve attention and focus and motivation whereas gaba
is actually one of your primary inhibitory neurotransmitters and so by increasing the
level of these neurotransmitters in the central nervous system it does appear uh that ectosteroids
do have some some stimulatory properties to them as well as some anxiolytic properties
to them and this does appear to be a common case with most adaptogens most adaptogens do appear to
have both stimulatory and inhibitory properties to them however ectostories specifically appear
to be a little bit more stimulatory in nature now this can be a good thing for guys that are
looking for a little bit of boost in energy and motivation however for guys that already have
an overactive nervous system there are a couple of different side effects to keep in mind here
namely just simply things like nervousness anxiety and a rapid heartbeat and even insomnia now if you
are somebody who tends to run into side effects related to anxiety stacking ectosteroids with
things like l-theanine or ashwagandha may be a good way to actually mitigate against the risk
of these side effects now the next mechanism of action i want to talk about real quick is the fact
that ectosteroids appear to be an aldosterone mimetic now aldosterone is a hormone that is
produced by the the adrenal glands that actually tells the kidneys to hold on to electrolytes such
as sodium and potassium and by doing so actually increases blood volume and thereby increases blood
pressure and so you would think that there may be a possibility of ectosteroids increasing blood
pressure however it is also important to keep in mind here that ectosteroids also appear to
bind to the estrogen receptor beta which also causes vasodilation and so when you increase
vasodilation it actually actually decreases blood pressure so this may not be practically relevant
simply because even though ectosteroids do appear to possibly increase blood volume
which does typically increase blood pressure and also again causes vasodilation which may kind of
negate the effects of the increased blood volume now this is one of the primary means by which
ectosteroids kind of improve the sensation of the pump in the gym however if you are particularly
worried about blood pressure i would just simply stack things like l-citrulline and sodium nitrate
on top of your consumption of ectosteroids just to kind of cover your bases now the next
mechanism of action that i want to talk about is ectis airwood's ability to possibly reduce
blood sugar now this is typically actually a good thing in most individuals especially if you are
consuming ectosteroids with a high carbohydrate meal however in specific situations where you may
already have low blood sugar like during a cut or during a low carbohydrate diet there may be some
issues with ectosteroids actually lowering blood sugar a little bit too much now the primary side
effects that are associated with low blood sugar are things like irritability and light-headedness
and nervousness and so if you start to experience some of these side effects it may actually just be
because of the the dropping of blood sugar now the obvious way to mitigate against the risk of these
side effects is to consume ectosteroids with a high carbohydrate meal and just to simply consume
more calories however this likely won't have much of an impact on most individuals that are aware of
their blood sugar and may actually be a good thing for some guys that are particularly hard gainers
you know when blood sugar drops typically there is an increase in appetite and so ectosteroids may
actually also improve appetite for guys that are trying to intentionally gain weight however for
guys that are at particular risk of blood sugar dysregulation i would just simply make sure to
not take ectosteroids on an empty stomach now the last mechanism of action that we're
going to talk about real quick is somewhat of an obscure mechanism and that is that um
ectosteroids appear to be p-glycoprotein pump inhibitors now p-glycoprotein pumps
are one of the means by which your body is able to clear drugs and toxins out of its
system and is actually the primary mechanism by which piperine or black pepper extract is able to
increase the bioavailability of certain drugs like curcumin now this can obviously be a good thing
in certain situations however it can also be a negative thing in particular situations and
i do think it's important to note here that um a lack of function of the p-glycoprotein pumps
is actually associated with symptoms of ibs and even alzheimer's disease now these are extremely
loose connections at this point however i do think it is worth noting here p glycoprotein
pumps are essential for your body's ability to clear toxins out of particular areas of the body
so again it's just something to keep in mind and is actually one of the reasons why i after doing
research for this video came to the conclusion that i'm actually going to reverse my stance on
cycling tercasterone and ectosteroids because of all of the different mechanisms of action
or rather the possible mechanisms of action i do think it would be prudent to cycle your intake of
terkestrom assuming that ectosteroids do have some level of biological effects in humans i
just think it would be prudent to take periodic breaks from supplementation just because we just
don't know the full effects and the level of effects of some of these these mechanisms of
action quite yet now i am still somewhat of a fan of ectosteroids and terkesterone i do
personally notice somewhat of an effect on muscular volumization and vascular effects
as well as some slight improvements in energy and performance in the gym now it is obviously not
a super top priority for most individuals there are a handful of other supplements that that take
first priority when it comes to building a proper supplement regimen however in the right context i
do believe that terkestrone has a place now if you guys are interested in a complete breakdown of my
thinking on the top supplements that can be used to improve overall health and performance i would
highly recommend checking out the complete guide to supplementation that i just finished this week
it has a breakdown of the nine top health goals and essentially like 10 to 15 supplements
the top proven supplements that can be used to help achieve those health goals and so again if
you guys are interested in something like that i would highly recommend it i put several months
of work into developing this guide so that you guys can kind of get a glimpse into my thinking
on specific supplements and so um if again if you're interested in that check out the link in
the description as well as links to my favorite products and services but other than that make
sure to leave a comment down below if you have any questions and i will see you guys next time