Hi guys! It's Petrina, your go to girl for learning how to make fit work in a crazy busy
world and today's video is going to be a follow up to last week's where I reviewed 23andme
and in this one, I'm gonna show you how to use Promethease, which is a very cool $5 tool
that will dig deep into your raw data that you got from the 23andme test or wherever
you had your DNA tested and this will give you all sorts of really cool medical info
based on your data. Now before I take you in the platform, I want to start you off with
big fat disclaimers so pay attention! Go ahead and put your listening ears on people. The
information you get on Promethease is not, I repeat not a medical diagnosis so don't
use it as such! Note that just because you have an increased risk for something doesn't
mean you're gonna get that something so calm the (bleep) down! Chillax people! Capiche?
Now having got that out of the way, let's go on in and I'll give you a big tour. Alright
so here we are on the Promethease platform. This is what you're gonna see after you pay
your $5 and you check all the boxes they give you for legal approvals and you get your raw
data uploaded and processed and I'm gonna remind you, Don't Freak Out! I know it looks
like a hot mess of technical data and you're likely gonna see some bad news pop up right
away, like this little gem on coronary artery disease for me personally. Note too that you're
gonna see that kind of stuff probably because they assign bad things a higher magnitude
level, so just take a deep breath and know that you're gonna filter, filter, filter to
get the most relevant and most interesting stuff that's for you.
As you see too, when you first get in you're gonna have a boatload of associations showing
up. As you can see here there are 19,139 rows on mine and that's a lot of information. It
would take me a long, long time to go through all 19,000 and if you have that kind of time
on your hands, go for it, but if you're like me and time crunched and you want to find
the most relevant and interesting info, you're going to filter. Now you're gonna see too
you can sort by topics and there's gonna be all sorts of different ones. You can scroll
down if you are just interested in a search group topic like eye color. You can see the
bits of information that's related to that topic by going that way. You can also do it
by medicines, medical conditions, ClinVar Diseases, your genes and as you'll see too
when you upload your information you'll have the option to pic a race that you're in. You
don't have to pick, but if you do, you're gonna be able to learn how frequent your gene
variation is within your pool of those in that same race. Mine is Caucasians from Northern
and Western Europe and if you look on the frequency tab for different pieces of information
you'll see a percentage and that means that particular variant is present in just 20%
of people in that race.
If you're interested in one specific thing already you can just go in that search tab
and type it in and as you'll see, you can choose to show information on SNPs, Genosets
or both. SNPs are single nuclear polymorphisms and Genosets, well rather than bore and confuse
you with all the details, I just say to have both selected when you are filtering. Repute
is just like you'd imagine. The reputation of the association, whether it be good, bad
or not set. I will say too that just because something is, the repute is not set it doesn't
necessarily mean that it's not good or not bad. It could be that someone just hasn't
assigned a certain repute to that particular piece of information you're looking at. All
of the pieces of information that you see are compiled in SNPedia which is sort of the
Wikipedia of DNA information that's heavily reliant on users going in and you know putting
information in so just because something is not set doesn't mean that it is not good or
bad. It could be that it just hasn't been set yet. I'm gonna go ahead and keep all checked,
but if you just want to see the good or you're a pessimist and just want to see the bad you
can limit it that way.
Magnitude is a really good indicator of just how interesting the information is likely
to be and note that this is subjective. This is again based on certain people who assign
magnitudes to it when they're going through data. When you hover over it, you'll see that
it says 0 is boring, 1 is unset or 2+ is interesting. So in order to filter down my results to be
a more manageable level to review, I'm gonna go ahead and set mine to 2. This way I'm gonna
weed out the stuff that's not likely to be that important in the grand scheme of things
and note too that even though the scale that you can set to filter goes up to 4. You could
find some things that are listed all the way up to 10. Like let's say the BRCA 1 is associated
with breast cancer. That's a 10. Denys-Drash, Frazier, Raine syndromes are all 9s as are early onset
Alzheimer's Disease.
References are gonna indicate how well researched certain findings are. I wouldn't go less than
2 for credibility purposes for mine because I'd like to see things that are more credible.
I'm gonna set it at 12. You can set it again at whatever number you like. If you want it
to be really credible you can go higher. If you want to see more things you can go lower.
It's all up to you and if you wanted to see only items where the SNP or the Genoset variation
is rare for your ethnicity type, you could also filter by frequency. The lower the number,
the rarer the variation is gonna be. For this demo I'm not gonna filter by frequency or
require a certain level, but if you wanted to again that's up to you.
Now the UI is your user interface and it defaults to the tool tips. If you're someone who wants
to go in and get really geeky and contribute to SNPedia you can use the editor mode where
you'd be able to edit certain things and make certain classifications. I'm gonna leave it
as tool tips. So in moving that magnitude to 2 and the reference is a 12, you'll see
those 19,000 results that I had in the beginning got reduced to a far more manageable 104.
Now if you like to cheat and see all that's come up after you've filtered, you can kick
back to times more button until you got up to the total.
Okay so once filtered and you're ready for review, note that the boxes that you see that
are outlined in red are those that have been classified as having a bad repute, a bad reputation.
The green ones are ones with a good repute and gray are ones that haven't been set. You'll
also notice highlighting in the frequency. There's always a color and the darker the
red, the rarer the variation is for your particular ethnicity. Now too as I said at the beginning,
it's gonna sort firstly based on magnitude so the higher magnitude stuff is gonna be
at the top of that list after filtering and it will go down to lower as you scroll down
and because usually our interest level is peaked by bad things more so than good, I
think the bad stuff are gonna have a higher magnitude so you're gonna be greeted with
some bad news once you get in and that's okay. Again it doesn't mean it's a diagnosis. It
doesn't mean you're actually going to get it. Like here the top one for me is the coronary
artery disease so don't freak out and if you're concerned about certain things you know talk
to your doctor. Make good lifestyle choices.
As you'll see, with most entries at the bottom, you can even click on different topics that
come up if you want to learn more. The medicines, there's also a medical conditions category,
medicines or a ClinVar to learn more about a particular topic or if you want to keep
it to learning more about the particular study that they're referencing, you can click on
that Rs link at the top to learn more. It will take you to the SNPedia version of it
where it has like an abstract of what the study is and it will also have PMIDs where
you can possibly see abstracts or if you can see the OA designation you can see the full
article online if it's something you want to learn more about.
I want to warn you too if you are starting to dig and clicking on the different tabs
to learn a little bit more, you're going to have to reset to get back to the filtered
results after you go back to Promethease. That can be a frustrating part in using this
system, but I wanted you to know just in case you wanted to click around that when you go
back, if you want to get it back to that filter you're gonna have to go through and filter
all over again. I wanted to note too as you can see with this that intermediate metabolizers,
the most potential useful information I think you can get from Promethease is that relates
to medicines. It's really useful to know how certain medications can impact you, whether
it be the metabolization rate benefits, the odds of you responding to certain drug treatments,
you can find that out by going through and going through your results.
It's really good to go through these and find credible studies and if you're concerned about
certain things, share them with your doctor and you'll sometimes see in these abstracts
of certain studies that there are ways to minimize your risk for certain things that
come up like here for age related macular degeneration it notes that I could eat a diet
richer in vitamins C and E, lutein, zeaxanthin and the minerals zinc and copper as to reduce
the risk. You can also learn not physical related, but mental and attitude. This is
a study on optimism and empathy. Again, it ain't all about panic mode and scary diseases.
You can find other little interesting tidbits of information, including this gem - that
caffeine will not make your breasts smaller. Learning is fun!
And that's it for my Promethease overview. I hope you found it tremendously helpful.
I know it can be really intimidating getting on the system, but once you know what everything
means and how to filter it to get the most relevant and interesting information it can
be a really powerful tool.
As always, if you have any questions feel free to shoot me an email at CoachPetrina@yahoo.com.
If like, check out my crazy sexy cool website over at PetrinaHammFitness.com. If you like
me are feeling the impact of Jonah stay safe, keep warm and have a great weekend. Bye guys!