Could Orlistat, also known under the brand names Alli and Xenical, help you lose weight?
This video will answer all your essential questions about this medication.
Orlistat is a medication prescribed to assist in weight loss.
Orlistat works by inhibiting the enzyme lipase, the enzyme responsible for breaking down fats in
your intestine. This action prevents the absorption of fats in the foods you eat,
so your body doesn't get the opportunity to use them. Instead,
the unabsorbed fat is passed, undigested, in your poo.
Orlistat is licensed for use in adults over 18 years, in combination
with a reduced calorie diet, with either: 1. A body mass index (BMI) of 30 kg/m2 or more,
2. 28 kg/m2 or more with associated risk factors, such as high blood pressure or diabetes.
Is there anyone who should not take Orlistat?
It is best to speak with your doctor before taking
this medication if you have any of the following conditions:
• History of malabsorption syndrome • Any liver conditions – particularly
cholestasis where there is impairment of bile flow • Individuals with chronic kidney disease
• Those with a history of vitamin deficiencies,
including ADE and K o The fat-soluble vitamins
What is the correct dosing of Orlistat?
Orlistat is available in 2 strengths, 120mg capsules and 60mg capsules.
In the UK, 60 mg capsules are available over the counter at reputable pharmacies,
and 120mg capsules are available only on prescription.
How to take Orlistat
It would be best to take Orlistat three times per day before, during,
or up to one hour after each main meal. Always take your medication with a glass of water.
Orlistat can impair ] the absorption of fat-soluble vitamins A, D, E & K. Therefore,
it is recommended to supplement your diet with a daily multivitamin.
How long does it take for Orlistat to work?
Orlistat gets to work soon after you take it. However, it may take several weeks of use,
in combination with a low-calorie diet, for you to notice the benefits.
Your doctor will aim to see at least a 5 % reduction in weight loss after 12
weeks. This target may be lower for those with type 2 diabetes. Your doctor may be reluctant
to continue prescribing this medication among individuals who don't lose the expected weight.
Are there any foods I should avoid?
Sticking to a low-fat diet whilst taking Orlistat is essential,
as higher side effects occur with fatty diets.
Can I Drink Alcohol with this medication?
It is safe to consume alcohol whilst taking Orlistat.
I have missed my dose. What should I do?
If you forget to take your Orlistat within 1 hour of your meal,
skip the missed dose. Remember to take your following amount as expected.
Do not take a double dose to make up for a missed one.
I have accidentally taken too much medication.
Consuming too much Orlistat will increase your risk of side effects. If you have
taken too much of this medication, you should seek medical attention.
Are there any side effects? Common side effects include:
• Abdominal pain • Change in your poo, even diarrhoea
o They may become fatty or oily o Experience a need to
open your bowels more frequently o Increased urgency for needing to pass a motion
• Increased farting • Oily discharge from your bum
Sticking to a low-fat diet can reduce your risk of these common side effects.
Rarely may people experience more concerning side effects.
If you experience any of the following, please consult with your doctor urgently:
• Inflammation and damage to your kidneys, liver or pancreas
which may present as a change in the colour of your skin, a change in the colour of your poo or wee
Inability to pass urine and abdominal pain
• Bleeding from the back passage • Gallstones
Allergic reactions are concerning as they may be life-threatening. Fortunately, life-threatening allergic reactions are rare.
Those with severe allergic reactions should call emergency services for assistance. Symptoms of a
severe allergic reaction can include: • Swelling of the face, lips,
mouth, and throat • Difficulty breathing,
wheezing or chest tightness • Allergic skin rash
Of course, this list is not exhaustive. For a complete list of side effects,
refer to the drug information leaflet with your medications.
Conclusion
I hope this video has supplied the answers you were looking for. Thank you for watching.
Of course, this video does not provide individual medical
advice and is only for information purposes. Do not consider this a substitute for professional
medical advice, diagnosis, or treatment. Please do not ignore professional
medical advice when seeking treatment because of something you have before.
If you believe you may have a medical emergency, immediately call your doctor or ambulance service.