- While drinking stuck at home in quarantine
without the distracting lights at the club
or the mood lighting of the bar,
we have noticed some peculiar things
about our face as we drink.
- So we decided to do a little research,
try a little experiment
and figure out why and how alcohol changes your face.
- Here are the rules of our experiment.
We are going to drink for 12 hours.
One drink every hour.
That might not seem like a lot to some people
but we are for sure lightweights.
We will take photos of our face
every three hours during the day
as we drink and one tomorrow morning
to see how alcohol changes our faces.
We are going to copy our day from yesterday,
the same amount of coffee, same two liters of water,
same veggie meals and snack,
one half-hour workout, our nightly one hour walk
and we already took photos every three hours yesterday
to compare our sober photos
from then to the drunk ones we take today.
Don't try this at home.
Oh, okay.
You're ready.
(foreign language)
- [Mitch] Where'd you learn that?
- I don't know.
I think I saw it once in a movie Ratatouille probably.
See you later, bud.
Oh.
- Okay.
Yeah.
Oh, from now on all
of our drinks will be measured to be around the same amount.
So if we have a shot of liquor
it'll be around 45 milliliters at 40% alcohol.
If we have a glass of wine,
it will be around 150 milliliters at 12%.
And if we have beer or cider
it'll be around 350 milliliters at 5% alcohol.
Cheers.
And I already have to pee.
See you in a minute.
- According to my understanding of biological pathways
it's probably not the alcohol, but I have to shit.
- [Mitch] Ooh, drink number two.
- We have got the good grapes
from a local brewery here in Toronto.
- [Mitch] Ooh look at these glasses.
- We got a Mariah Carey.
Then we got a Charles Darwin,
who we're also gonna fill up
'cause Charles Darwin, as we all know was the bottom.
- This is the first time I'm having a beer type thing
before noon.
With many more drinks to come,
we thought it would be fun to try
and explain the science of alcohol
or getting progressively more drunk through the day.
- Now you know how we make our videos.
So what is happening in your body right now?
Alcohol is absorbed into your bloodstream
through the GI tract and starts getting absorbed
in your stomach, which is why it can hit so fast.
The alcohol molecule then moves through your blood
to the brain and central nervous system
and changes how your neurons or brain cells communicate.
You have two important neurotransmitters in the body.
Glutamate, which affects excitatory neurons
and GABA, which affects inhibitory neurons.
It turns out alcohol suppresses the excitatory
neurotransmitter glutamate,
and increases the inhibitory neurotransmitter GABA,
which causes information flow to become slow,
causing you to feel less, perceive less, notice less
and remember less.
The increased GABA hushes the background noise of activity,
clarifying your thoughts to an excessive degree.
You think less with great clarity.
Hence you're like this dog is amazing.
Essentially alcohol makes you think clearly about nothing.
- Guess what?
I have to pee.
- I haven't peed yet.
I'm sick or are you sick?
- I wanna know your most iconic drunk story.
- I was drunk a lot in my youth.
I was in university,
I learned the bad romance dance.
You know the part, which she goes on the floor
and she puts her leg up.
Oh my God, whole bar watching me leg up everything.
But I also was a university student,
didn't have very much money.
I had the same emo tight black pants,
with a huge rip in the crotch.
As I lift my leg up, my balls fall out.
Like hold mid Lady Gaga dance routine out of the bar.
Yeah I got kicked out for my balls
falling out on a dance floor.
- I have to pee.
- [Greg] Time for the first photo.
Do you feel like your face is different?
- Um no, I actually feel like it's harder
not to smile right now.
While the first few drinks were fun,
things started to unravel.
What just happened?
Tell everyone.
- I forgot I had therapy.
(both laughing)
- I am starting to feel sick.
My body is, my brain's still having fun
but my body is starting to feel not so great.
And we're only halfway through.
- Ugh I hate this.
- I can literally feel my hangover starting.
Gotta pee BRB.
- [Mitch] What are you doing?
- I'm looking at TikTok aren't we all?
- [Mitch] Yes, you're turning red.
It's happening, the flush.
Greg's classic red face meant it was time
for some more drunk science.
- [Greg] Three, two, one go.
- Now the reason I may be feeling a little bit sick
and Greg may have a bit of a red face is
because of complex biochemistry in our bodies.
Alcohol is processed in the liver where enzymes
break down the alcohol into acetaldehyde.
Acetaldehyde is 10 to 30 times more toxic
than alcohol leading to the headaches
and nausea we feel while drinking.
In order to get rid of, and excrete the alcohol byproduct
of acetaldehyde,
it needs to be converted to acetate by glutathione
of which there's only a finite amount.
East Asian people have a gene variant that leads
to higher levels of acetol aldehyde
causing increased sickness and potential for red face.
Greg's not East Asian, obviously
and likely his right face is for a different reason.
Studies have found that British, Irish
and Indigenous Americans get alcohol redness
due to changes in metabolism of vasoactive amines
such as histamines,
which cause vasodilation of blood vessels
in the face and can also lead to inflammation of the face.
So we will see what happens
to Greg's British ass face later on tonight
slash in the morning.
- Why did you just talk about my face there bro?
It was similar to what we had in India.
- Oh my God. - [Mitch] Okay.
Oh, it looked at your butt crack.
- Wait really is my butt out?
- [Mitch] No.
- There's nothing more unattractive than a butt crack.
- [Mitch] A little like hot pink like underwear though.
- Really?
So we are here at Dosa.
If you're in Toronto, come here it's so amazing.
I feel like I'm James Charles.
It is so amazing.
We ate here yesterday for dinner,
we're eating it again for dinner today.
I am drunk and I honestly just love this restaurant
and I want people to come here.
- Love Dosa.
- We're at 11% alcohol.
So I'm gonna go a bit over 150.
If you are around, people have like classist ideologists,
they'll say it's skin contact natural wine.
I love wine that looks like a hangover piece.
- It's six o'clock we've had nine drinks.
- Yeah, alcohol made out of potatoes.
Potatoes!
Do you have agua congas?
Congas.
- You ready to have a sip or do I have a suck?
- Hang on girl.
It's your life, I'm just living in it.
- [Mitch] At this point, things got a bit weird.
We're just gonna leave this here.
(upbeat music)
(slow music)
(rock music)
(upbeat music)
(rock music)
Yeah, we decided to do one final drunk science
on why alcohol makes you pee.
- Is Bio chemistry 101.
- Part one is that I've just consumed so much liquid today.
But on top of that, there's another factor.
There's another factor. - Oh factor.
- Your kidneys. - They're really cute huh?
- They're so cute.
Your kidneys is where your body decides to reabsorb water.
You are dehydrated is gonna to reabsorb more water
so that you stay hydrated.
Antidiuretic hormone goes to your kidney creates aquaporins.
And these aquaporins are proteins and they reabsorb water,
from your kidneys back into your body.
- So ultimately alcohol has an impact on ADH
by decreasing it.
(laughing)
When you drink, your body doesn't have the same mechanism
to save the water.
- Yes.
- And so it just goes through your body in and out.
- And then you pee all potassium, UPF sugars.
- We will relate to tomorrow morning
when we are H-U-N-G over because-
- I thought you were gonna lean over and say hung.
And I'm going to say, "Oh boy!"
- Girl, that's all the time.
- As we made it to the last few drinks,
it got a little rough.
- Okay.
It's become too much for me.
You hate alcohol?
- Yeah, I think it makes me feel not aware of the world.
It makes me not feel present
and we only have like the years we're alive.
I don't want to spend it like this.
- I would not do this again.
- No pictures.
- [Mitch] We're taking a photo now.
- TMZ no.
- [Mitch] Final photos captured.
We went to bed bracing for the morning.
Of course we were so hung over we forgot
to vlog us taking our morning pictures.
- So here we are, a week later.
- It took us that long to recover from the hangover.
- We did not film our hangover 'cause it was disgusting
and depressing.
- I have not been that hung over in a long time
because we don't drink nearly as much anymore.
It hurt.
We are now going to look at our comparison.
(laughing)
- Oh my God.
- Okay.
It is obviously so red, but it's not that bad.
It's actually isn't that bad.
- [Greg] Like I mean, it is for like any other person.
- It's interesting that it happened presumably a lot
at this point in the middle of our drinking
or near the beginning.
- I always find that it's like so frustrating to me.
It's like, when I first get to a party
within the first hour or two, everyone's like,
"Greg you are so red, you look like Santa Clause."
I feel when my, when I drink my face gets hot.
- [Mitch] It's interesting because it's so defined
along this sort of line.
- Okay, I need to not drink, I'm like alert.
- Okay, my turn 10:00 PM sober versus drunk.
Uh! - Oh!
(both laughing)
- [Greg] This is worse.
- It's worse yeah.
Oh what?
I actually like, it looks like-
- What's wrong with your eyes?
Mitch you look so funny.
'Cause like you're trying
like you have a little snarky murky.
- [Mitch] Yeah I'm trying to be pretty in the drunk one,
but it's not working.
- Do your eyes get like a lazy when you drink?
- What I find interesting is that's kind of a caricature
of a drunk person.
It makes me think from an evolutionary perspective
if being drunk is a warning sign to somebody
because it shows, yo my face no longer look symmetrical.
- Or like, yeah, you look sick.
- But I also like got a pimple, which it maybe
a total coincidence. - [Greg] Oh wow.
- But I will say I got more pimples than I normally would.
- Huh you kinda look like, you look cute in the drunk one,
as a drunk person.
- It's nerd versus like sexy.
- Yes sexy.
- No, I wouldn't go with sexy.
But it's like, you know, it it's very like-
- But it's not nerd, you look sexy in the left one.
No, you definitely just have a squinty eye.
Me at 10:00 PM sober versus drunk.
Okay.
- Huh yours is not nearly as bad as mine.
- And I'm less red than I was at 4:00 PM.
I don't, I'm impressed.
- I mean it might be in your genetics.
- What?
To handle alcohol?
- I don't know, you're like Viking beard.
And you know what I mean.
I feel like people often joke about certain cultures,
like being able to drink so much
and I feel your genetic makeup looks like that.
- It's surprising like we did this as an experiment,
and then this comparison is not nearly as bad
as I thought it would be.
When I think about what I felt like then.
I don't even remember taking this photo.
- Yeah. All right, all right.
Made it to the finale the morning after,
we were so hung over.
- I don't remember.
- We showered and I
and it was just like, we have to do it
but I remember feeling miserable.
- [Both] Oh my God.
- So, Oh no.
Did I get dirt in my shirt even?
- Wait that's- - Ew.
- I can't believe that you've already seen that photo.
- [Mitch] That is bad.
You also look like bloated.
- Sick, so the inflammation has kicked in,
my left eye is bloodshot.
Like popped blood vessel.
I look so sick.
- The shape of your face has changed.
- It's inflamed.
- It's inflamed
even in your forehead. - Look at my tonsils.
And I actually almost like a pale.
I have a flush face in general,
but in the left one there's a little bit more
like blood flow.
If you have something where you want to look good
do not drink the night before.
I would be so embarrassed that that's what my face
would look like that day or morning.
Oh my God.
You look so bad.
- [Mitch] I look pissed.
- [Greg] And you're inflamed.
- [Mitch] Yeah.
- [Greg] Look at face.
- [Mitch] Uh huh.
- [Greg] It looks like you were also kind of
got your tonsils out.
- I remember that morning 'cause I had a headache.
I felt sick,
so to have a bright light in your face is actually
like makes you angry.
- Oh my God the two of us that next day,
we were in horrible moods.
Hot tank hangovers are the worst.
- Would you ever do it again?
- No, I really am so disgusted.
- I would never do this again.
No, I would never do this again.
- Yeah I know, I know, I know.
- It was like a little bit of fun,
but then it was overall not that positive experience.
- So if you're a drinking 12 drinks in 12 hours,
this is what you're going to look like the next day.
Is it worth it?
- I know everyone's experienced where you drink
for an extended period of time.
And I think this is just interesting evidence
that you probably look busted to those around you.
Not only in the morning after
which we all kind of expect, but the night of the event.
- If you want more drinking content with us,
we are gonna link to our podcast
where we explain even more information about drinking,
what it does your body.
And yes, we drink throughout the podcast.
- And it's on YouTube now.
So if you haven't checked out our podcast before,
you can go there or you can listen to it
on any of the audio sources that you would use.
Are there any other things you want us to try
that might change our faces, in the name of science?
You know, we're willing to put ourselves through things,
we are in quarantine we got nothing to do.
- Honestly, we have nothing to do.
You tell us what to do, we'll do it.
- Thank you so much for watching,
subscribe if you haven't already, like this video
if you want more like it
and we will see you next time for some more science.
- [Both] Peace.
- I have to pee.
- I can't see.
I wasn't gonna cry.
- The changes in metabolism of that.
Oh.