To begin with briefly,
go over what
exactly ALS is. ALS stands for
Amyotrophic Lateral Sclerosis and is a rare and progressive neurodegenerative disease,
only affecting about 3,000
Canadians. ALS causes gradual paralysis and affected individuals due to
the communication issues between the brain and the muscles of
the body that are associated with voluntary movement.
This is a result of the degeneration and death of
motor neurons.
Specifically,
both the upper motor neuron and lower motor neurons
play a role in ALS progression.
Upper motor neurons,
are a part of the central nervous system of the
brain and are responsible for carrying information,
regarding the initiation of voluntary movement.
These upper motor neuron are connected to a lower motor
neurons were confined to the spinal cord.
Ultimately lower motor neurons,
connect to the muscles of the body and allow them
to complete the voluntary movement.
Think of it like a relay race.
The brain processes information to the upper motor.
Neuron would then carry This information and give it to
the lower motor.
Neuron,
these lower motor neuron,
then complete the race,
by passing it to the endpoint,
the muscle,
with ALS,
both the upper motor neuron and lower motor neurons are
damaged.
So,
the muscles are unable to receive voluntary action signals because
of inadequate communication.
This causes the muscles to lose their ability to perform
proper function and they began to waste away.
That's the brain progressively loses the ability to commence and
regulate voluntary action in
order for a physician to diagnose.
An individual with ALS.
There are some requirements that must be met according to
the widely,
accepted El escorial criteria.
This criteria can be broken down into to the first
component of the criteria states that for an ALS diagnosis.
It requires the presence of three factors,
one evidence of lower motor,
neuron degeneration to Upper motor neuron degeneration,
and three the progression of symptoms and signs reading region
to region,
or within a region,
to check for this criteria mentioned and determined evidence of
motor neurons degeneration,
the signs and symptoms of an individual has to be
observed.
When discussing the signs of a disease.
We are referring to what can be seen or measured
in an individual signs of upper motor neuron degeneration or
associated with weakness?
And atrophy,
where are signs of lower motor neuron degeneration are related
to spasticity and Pad logic reflexes.
That's here.
We have compiled a list of signs associated with ALS,
which may include tripping Spurs feet and difficulty swallowing.
Where are the symptoms are what an individual experiences or
feels show me to dr.
Disrespect.
ALS.
This includes feeling of weakness,
fatigue and muscle cramping.
There's difficulty in diagnosing,
a last because it's size and some other neurological diseases.
Like,
West Nile virus kill you and many others.
However,
the second part of the ls,
guard,
your criteria help you load the other possibilities.
Essentially,
this part of the criteria States,
the diagnosis of absence of two factors.
One evidence that may explain.
The signs of lower and upper motor neuron degeneration are
called by another disease or two evidence that may explain.
That the observed clinical signs are caused by this part
of the criteria's verified using various cats,
which include electromyogram magnetic,
resonance,
imaging blood and urine tests and muscle.
Biopsy will not provide you all with some details about
the Tesla stood before us in the TNT.
The doctor about is the electrical activity by inserting a
needle or electrode into various muscle smooth skin.
Electrical activity,
tell the doctor,
when do specific muscles in the body are Contracting.
And when they are arresting,
these have the doctor,
determine whether they have another nerve or muscle condition causing
the same symptoms used in conjunction with other tasks,
Eng study extent to which nerve Supply to muscles or
the lack of.
They also used to confirm lower motor neurons,
generation and magnetic resonance.
Imaging.
Also known as the MRI test uses various radio,
waves and magnetic fields to produce images of the spinal
cord and the Brain.
This is not used as frequently but in rare cases,
MRIs of spinal cord,
May provide enough information to support the diagnosis of ALS
also.
Request a blood and urine tests to be completed analyzing
blood in urine samples,
allows them to get rid of the other possible causes
of symptoms and signs of blood in urine samples.
Called 80h to DG.
This marker is an indicator of oxidative stress experience that
our bodies and other Does marker is modified version of
our DNA,
which formed as a result of the DNA,
consistently going through damage and repair due to out ALS?
I said those are lies will see increased levels of
this marker.
If the doctors more convinced that an individual has a
muscle disease over having a last,
the doctor recommend them to go do a muscle biopsy
during this a part of the muscle is Mahmood and
get Annalise in a lot.
I have seats are not typically done unless there's over
laughing and symptoms,
observe and other diseases as such.
This is using the last resort in the diagnosis process
in conclusion by meeting each of the point.
In the app,
for mention criteria at physician,
is able to diagnose an individual with ALS for sitting.
That's the patient will receive.
The recommended treatment to help with reducing symptom severity to
get more information on the diagnosis of ALS or any
LS related information,
please visit ALS