If you’re an aging man who wants to look younger,
and you’ve decided that you want to do something about your skin,
then you’ll want to watch today’s video.
In it, I talk about 5 growth factor peptides
that have been recently discovered to have a big impact on your skin’s suppleness, on it’s thickness,
on it’s thickness, and on it’s collagen and elastin synthesis.
So stay tuned.
This is Lance, and if you like this type of content, then please,
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For a long time now, women have been the experts when it comes to skin care.
But ever since the era of the metrosexual, men have become not only more knowledgeable about skin care,
but more interested in taking good care of their skin.
And us older guys are finally following suit.
As the science of skin care has advanced over the last decade or so,
some really interesting discoveries have been made,
and one of the more interesting has to do with growth factor peptides.
In this video, we’ll be delving into these small-chain amino acids
that can have such a big impact on your skin. We’ll lightly cover the history of peptides in skin care,
and then we’ll talk about what is the skin growth factor definition
and we’ll jump into each of the growth factor peptides, and just what each of them does.
You know, as an aging male, if you want to look your best,
then you need to give some serious consideration to skin care.
If you don’t take good care of your skin, then you’re going to show signs of aging before your time.
The other day I was reading an article on skin care in LifeExtension magazine,
and the information that it covered was so interesting, that I wanted to share it with you.
Human skin is mostly made up of collagen,
which is a protein made up of long segments of amino acids arranged like a chain.
When collagen breaks down,
these long-chain amino acids are broken down into short-chain amino acids called peptides.
And these peptides play an important role in the replenishment of the skin.
When collagen breaks down,
these peptides signal the skin that it has lost collagen and that it needs to generate more.
But as we age, collagen becomes depleted, due to the effects of environmental factors,
including sunlight, and of the aging process itself.
As the collegen becomes depleted, there are fewer and fewer collagen break-down products,
and less and less new collagen gets generated.
When skin care peptides are applied topically,
your skin reacts to these peptides in the same way that it would to collagen break-down products,
and you begin to generate new collagen.
Your skin becomes more supple and less wrinkled, taking on a more youthful appearance.
Makers of skin care products have known about this for decades,
and that why there are so many products with skin care peptides available.
Skin care peptides such as Matrixyl have been on the market for a long time.
But new research has exposed some peptides that are particularly effective at repairing and reversing chronological and environmental damage.
And these peptides are called growth factor peptides.
Typically, when your skin becomes damaged,
there is a release of skin growth factors that start the repair processes and coordinate them.
And they do this by communicating with cells, such as keratinocytes, fibroblasts, and melanocytes.
Keratinocytes are present in the outer layer of skin
and form a barrier against environmental damage by making up about 90% of the cells in the epidermis.
Fibroblasts and melanocytes are present in the bottom layer of the skin’s epidermis.
Fibroblasts are a type of stem cell that synthesizes collagen and the structural framework for tissue;
and melanocytes are the cells that produce melanin,
the dark pigment responsible for skin color.
Before I get into growth factor skincare,
if you guys are really into skincare and have been take good care of your skin all along,
leave me a comment and let me know what skin care products you like.
Let’s all share the knowledge.
Skin care researchers have identified five key growth factors
that regulate skin repair and protect against premature aging.
The first of these is Fibroblast Growth Factor or FGF.
FGF triggers the growth of dermal fibroblasts responsible for generating major skin matrix
components such as collagen, elastin and fibronectin, which is a protein that binds to the extracellular matrix.
FGF play a particularly important role in wound healing and the formation of scar tissue.
Next is Acidic Fibroblast Growth Factor, or AFGF.
This peptide plays an important role in epidermal cell growth
by boosting the growth and differentiation of epidermal keratinocytes,
and it rejuvenates both the epidermal cells and the underlying fibroblast cells.
When combined with other growth factors,
it also promotes DNA synthesis
and stimulates cell proliferation and differentiation associated with wound healing, tissue regeneration
and angiogenesis, which is the formation of new blood vessels.
Another growth factor peptide that is important to skin repair is Epidermal Growth Factor, or EGF.
This polypeptide was developed to speed wound recovery by stimulating skin growth at the cellular level,
and it’s so successful, that it’s developers were awarded a Nobel Prize for this breakthrough.
It accomplishes this by diminishing the inflammatory and oxidative stress response following skin damage.
Then there’s Vascular Endothelial Growth Factor, or VEGF.
This growth factor helps to boost the delivery of oxygen and vital nutrients by stimulating the growth of new blood vessels.
It’s part of the system that restores the oxygen supply to tissues when blood circulation is insufficient.
The normal function of VEGF is to generate new blood vessels after injury,
in muscles after a workout and to bypass blocked vessels.
And finally, there’s Insulin-Like Growth Factor 1, or IGF-1.
In the human body, IFG-1 is metabolized from Human Growth Hormone in the liver,
and it’s primary function is to activate cell growth, protein synthesis and the release of energy.
As we age, our levels of IGF-1 go into decline, causing the dermal fibroblast to become less responsive.
Topical IGF-1 can stimulate both epithelial cell and fibroblasts to increase proliferation rates.
And due to it’s ability to increase the responsiveness of fibroblasts to occurring cytokines,
it can also increase the new production of collagen.
And, it protects against the breakdown of collagen by down-regulating the production of collagenase,
an enzyme that breaks the peptide bonds in collagen.
Now, in our youth, these five growth factors control cellular growth, proliferation, and differentiation
to give skin the ability to completely renew itself. That’s why teenagers
and twenty-somethings can fight off the damaging effects of sun exposure, pollution
and advanced glycation end products, or AGEs…temporarily.
But as we age, decreased production of these growth factors
undermine the skin’s ability to maintain structural integrity and function,
causing it to become thinner, less supple, less elastic, less hydrated and more prone to wrinkles.
Clinical human trials have shown that topical preparations that contain one or more, but not all,
of these five growth factor peptides can boost collagen production and elastin synthesis,
it can promote epidermal thickening, and it can calm inflammation.
Furthermore, these studies found that these improvements in skin conditions
were also present in skin that was aged and photodamaged.
However, when all five of these growth factor peptides were physiologically balanced in a single topical formula,
these findings were even more impressive.
In one clinical human trial, female subjects who applied a topical formula daily,
which contained all five of these growth factor peptide, experienced the following results:
• The topical formula reduced wrinkles under the eyes by 46%.
• The formula minimized the appearance of crow’s feet by 21%
• It boosted skin elasticity by 47%
• And it elevated skin hydration by a whopping 64%;
with an improvement of 83% immediately following application.
Pretty compelling evidence that these growth factor peptides,
when formulated correctly in a topical cream, really work.
But where do you get them? Well, like everything else, you can do a search on google.
I found several different suppliers that have formulated a growth factor serum.
And they cost upwards of $50 to $75 for a bottle or jar.
But I use LIfeExtension.com for most of my supplements,
and since a lot of the information in this article came from LifeExtension magazine,
I figured they would probably have their own formulation. And they do!
If you’re interestedin this, I’ve put a link to their site in the description below. So go and check it out.
OK, I think that about covers it. We’ve taken a look a the role that peptides have played in skin care,
and we’ve examined each of the growth factor peptides, and what they can do for your skin.
Now, I’ve ordered a serum with the growth factor peptides
and in a couple of months I’ll report back to you and let you guys know how well they worked.
That’s it for me, I’m outta here. Hey, if any of you guys are into taking good care of your skin,
leave a comment and let me know what products you use, I’d love to hear about it.
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’Til next time, thanks so much for watching.