We're going to talk about a couple of new topics in cognition Alzheimer's one of them
is there's a new chat bot it uses artificial intelligence and it can diagnose Alzheimer's
in time for intervention the key thing is in time for intervention
we're not going to go that deep on that today we're actually going to talk about a new
wonder drug discovered at UCSF that's taking mice and turning Alzheimer's
demented mice back into youthful thinkers they're solving their way through puzzles now and we're
not talking about over months or years we're talking about practically overnight and that's
a "practically overnight" now here's a clue why am I showing Rapa Nui Easter Island
well I'll go a little bit deeper into that clue before we dive into the topic
you remember Easter Island again the official or the native name for Easter Island is Rapa Nui
there was a bug discovered out there a bacteria and a chemical a biological chemical
known as sirolimus it's a macrolide it's a type of antibiotic and it's called rapamycin does
rapamycin ring any bells for you its most common use is as an immunosuppressant it's covering
stents it's used for kidney transplants for stents it helps decrease rejection of the stent and it
comes from the bug that I mentioned Streptomyces hygroscopicus it inhibits MTOR mammalian target of
rapamycin which is all about autophagy now wait a minute we're going down a bunny hole let's go back
and talk about UCSF and their new wonder drug and then find out what that has to do with autophagy
and rapamycin that black market youth drug the article is in magazine called E-life I had never
heard about it I saw some of the press releases on it again we're talking about I wouldn't have
believed the claims or the magazine itself E-life but I saw that it was coming from UCSF
so I think it's worth taking a look the official title is Small Molecule Cognitive Enhancer
Reverses Age-Related Memory Decline in Mice and by the way you keep seeing this image this is a
picture of that small molecule stress response inhibitor that's the term here ISRIB Integrated
Stress Response Inhibitor so basically here's the bottom line on this it talks about how there's a
stress response and that stress response closes down a lot of things like protein development and
further function and development of cells that was developed to help free cells when they need
to be frozen for example when a virus has infected that cell you do not want it to make new proteins
because it's been hijacked by the virus itself they talk about a couple of via markers activating
transcription factor four ATF4 and another one which I won't repeat the technical name basically
what happens is ISRIB this small protein inhibits this activity this integrated stress response
when it does it begins to reverse memory problems in mice they can now start navigating through
mazes that they were not able to navigate the day before because of their age-related
memory decline they're using this ISRIB by the way in other places like reducing immune profiles
interferon and T-cell-mediated responses and some other things as well so again
it's starting to sound a little bit like our old friend rapamycin multiple different uses
all involving protein development by cells and yes that's what's going on in fact what they go on to
say is that it's very much related to rapamycin and MTOR MTOR which impacts our rapamycin which
impacts MTOR MTOR is the protein within the cell which is actually named after rapamycin mammalian
target of rapamycin you see rapamycin pushes this process autophagy one way and it looks like ISRIB
pushes it in a different way the two of them together seem to be creating some balance
where have we heard of MTOR before we did a few videos on a fellow named David Sabatino he's a
incoming medical neurological researcher at MIT Massachusetts Institute of Technology he's
evidently up for some big awards due to his work with MTOR again we've talked about stimulating
autophagy through fasting and other means and the fact that this image for example came from the
December 26 New England Journal of Medicine where they showed yes fasting can stimulate autophagy
again there's other things that can stimulate autophagy as well MTOR and ISRIB now and rapamycin
so to go back and put a cap on this it's maybe reversible that's according to Susanna Rosi
and I'm not talking about autophagy I'm talking about age-related memory decline
her quote was a kind of reversible blockage rather than a more permanent damage
brief ISRIB treatment can reboot mouse spatial brain function almost overnight they also looked
at the hippocampus specifically which is a major focus of human cognitive decline with
Alzheimer's hippocampal function and connections began to return to normal so sounds like it could
be very promising but you know what so did rapamycin hopefully we don't have to wait as
long for ISRIB to become a big deal as we've had to wait for rapamycin thank you for your interest
why wait for a disease and hope for a cure I used to be an ER doc my name is Ford Brewer
I quit er after a few years because it was just so frustrating most of the things bringing people
into the ER are things that should have been prevented including heart attack stroke number
one cause of death number one cause of permanent disability people think that you're just going
to have those and that they're not predictable both of those are wrong they are predictable
and you don't have to have them usually it's lifestyle lifestyle is more important than
supplements and even prescription drugs and even stents and surgery but the current times are tough
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