The program for today about people taking horse ivermectin
before we do that let me go ahead and cover some of the comments about ivermectin I had a patient
send me some information about ivermecton I had seen a couple of the videos on it you can't help
if you go onto YouTube at least in my space to be hit with the video of the doctor appearing in
I'm blanking on his name the doctor appearing on in front of the legislature with his impassioned
plea for the government to put out ivermectin programs for mass consumption I went ahead and
reviewed that I reviewed the science and we're going to talk about that science some today
the science clearly has some good evidence I think it's a little bit better than what we had for
hydroxychloroquine again we'll get into the details that's actually what this video is about
on April 10th 2020 the FDA sent a letter to stakeholders about the use of ivermectin
and it said people should never take animal drugs I saw that and I thought gosh the FDA
is overreacting again and then I saw this video that we're going to show you in a few minutes
I don't think they were overreacting the FDA Center for Veterinary Medicine has recently
become aware of increased public visibility of the anti-parasitic drug ivermectin after the
announcement of a research article that described the effect of ivermectin on SARS-CoV-2 in a
laboratory setting the antiviral research uh pre-publication paper the FDA-approved
drug ivermectin inhibits the replication of SARS- CoV-2 in vitro it documents how SARS responded
to ivermectin when exposed in a petri dish that's what in vitro means the FDA is concerned about
the health of consumers who may self-medicate by taking ivermectin products intended for animals
according to the FDA people should never take animal drugs ivermectin is an important part of
a parasite control program for certain species and should only be given to animals for approved uses
or as prescribed by a veterinarian in compliance with the requirements for extra-label drug use
due to potentially elevated interest in ivermectin following the new research some products may not
be available so let's go back and take a little bit deeper look at some of the research and just
you know start with what is ivermectin it's a multifaceted medication it's widely used it's FDA-
approved it's an anti-parasitic medication it does have some known antiviral and anti-inflammatory
properties it has been included on the WHO's list of essential medications so it's not it's not an
out there kind of medication it's something that's on that WHO list and the things on that list are
everyday kind of medications I have prescribed ivermectin in the past for things like head lice
ivermectin was identified in the late 70s and first approved for animal use in 1981
its potential use in humans was confirmed a few years later it is a what's called a broad
spectrum drug with high lipid or fat solubility it possesses numerous effects on parasites
nematodes arthropods flavivirus mycobacteria and mammals through a variety of mechanisms
since 2012 multiple in vitro studies have demonstrated that ivermectin inhibits the
replication of many viruses including influenza Zika dengue yellow fever and West Nile viruses
now it's potentially going to prove to be an effective treatment for COVID-19 maybe effective
treatment and maybe an effective preventive maybe a little bit too early to say but again a lot of
interesting information at a press conference on December 4th the FLCCC Alliance this is another
group that's called on national health authorities to immediately review medical evidence showing the
evidence of ivermectin for the prevention and early treatment of COVID-19 they say
they stand for and this is what FLCCC stands for Frontline COVID-19 Critical Care Alliance
over the past several weeks the FLCCC alliance conducted a comprehensive review of the rapidly
emerging science at round which is at that point 11 studies demonstrating ivermectin as
a potential solution to the unprecedented global surge for the COVID-19 epidemic again go into two
of these studies that they listed number two here and number eight study number one or it's
listed on number two on the previous page it's a June 2020 study it proposed the mechanism of how
ivermectin works it's the study mentioned in the FDA letter of April 2020 cells were infected
with SARS-CoV-2 for two hours prior to DMSO or ivermectin at the indicated concentrations
samples were given at zero and three days post-infection for quantification of the viral
load a single treatment was able to affect about a 5,000-fold reduction in virus at 48 hours in cell
culture so I don't think anybody's arguing the fact that it has a big impact in the petri dish
the proposal on how SARS-CoV-2 infects the cells this is where we get into some of the geeky
stuff about mechanisms IMP alpha beta 1 it binds to the coronavirus cargo protein in the cytoplasm
and translates it through the NPC or the nuclear pore complex and again this is just a geek alert
this part won't last very long but it's very interesting to those of us who are interested
in biologically how does this happen basically what it's doing is keeping the virus mechanism
from getting imported into the nucleus of the cell back to script IMP alpha and beta 1 are importins
that means proteins that transport other proteins from the cytoplasm of the cell into the nucleus
inside the nucleus the virus-importin complex then falls apart at that point the viral cargo
can reduce the host cell's antiviral response leading to enhanced infection so again it's
basically disabling a part of the virus's ability to capture the cell and the cell mechanisms for
making proteins so how ivermectin may inhibit SARS-CoV-2 ivermectin binds to and destabilizes
that importin protein importin the protein that transports other proteins across that nucleus
membrane that prevents the importin from binding to the viral protein and prevents it from entering
the nucleus this likely results in reduced inhibition of the antiviral responses leading
to a normal more efficient antiviral response from that cell study number two is the ICON
study in October 2020 it showed how ivermectin benefits hospitalized COVID-19 patients this
was many of you who are reading about this and studying it I believe this was the South Florida
study the study question was this is ivermectin associated with lower mortality rate in patients
hospitalized with coronavirus COVID-19 the results a retrospective cohort study consecutive
patients hospitalized with confirmed severe acute respiratory distress syndrome from coronavirus 2
infection at a four hospital consortium in South Florida analysis shows statistically significant
lower mortality rates in the group treated with ivermectin as compared to
the group treated with the usual care now statistically significant meant 15 percent
versus 25.2 percent so the interpretation in this study was that ivermectin was associated with
lower mortality during treatment of COVID-19 patients especially in patients who required
higher inspired oxygen or ventilatory support so this document came from that FLCCC that we talked
about this is their protocols outpatient protocol on the right in other words you've already got
infection and this is what they're recommending you take ivermectin 0.2 milligrams per kilogram
on day one and 3 4 thousand of vitamin D3 2 thousand of vitamin C two or three times daily
quercetin and zinc we've talked about all of these vitamin D3 vitamin c quercetin zinc melatonin and
aspirin you see that on both of these you also see it on their prophylaxis protocol
continue to get great feedback regarding the webinars and here's why you know on the
internet when you hear a webinar you expect for somebody to try to sell you something we're not
doing that we're trying to tell you something people are coming in with their labs from Quest
inflammation panel OGTT insulin survey response and then they're finding out do
I have inflammation do I have insulin resistance and where does that fit in terms of other folks
we're getting ready to start one for CIMT as well so again people are really
excited about finding out their own status looking forward to seeing you there thanks