hi i'm dr john thanks for joining me
araji's quick clip
on botox this applies knotting for botox
with dysport
xeomin and juve the new why i'm doing it
the new
doxy uh which is coming from rebonds is
a six-month product
we're going to be talking a lot about
mechanism of action
is it simply a higher dose does it have
its own mechanism of action
i wanted to show you then how botox
and botox-like products on the market
work today
you know really we don't fully
understand
i'm just telling you the exact mechanism
of action
through the snap proteins that we do not
fully understand
but let's look at it today i talk a lot
about its role in anti-aging
in making you look younger and botox
dirty little secret
it really doesn't make you look younger
it doesn't build collagen
it can give you a little bit of glow it
can change oil production
it stops muscle movement how does that
work
let's dive in three seconds
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the mechanism of action of botox is what
we're talking about because so many
people come and get it
and here's what you'll hear hey inject
me up here
i want a brow lift it always works it
lifts my
eyes the reality is if you take away
lyft you have to get droop and in
treating
the depressors the frown which is what
botox was first approved for one of the
first areas
and it's what xeomin is approved for
dysport
and juvo that stops the depressors
if you do not treat the forehead
therefore
you allow movement up here and you get
lift it's the same with the brow lift at
the edge
there are downward fibers of this muscle
the orbicularis oculi and those downward
fibers
pull down if you stop the movement
someone juice would work
paralyzed a lot of people don't like to
use that when we're talking about toxins
because people associate it with
botulinum toxin and people believe
you can get systemic botulinum
from this product we're using micro
doses
with spasticity with uh
other applications therapeutic
applications we use much higher doses
um but so we're using baby doses
probably on the face the largest area of
dosing
would be the master because it can get
quite large
so how let's dive in i want to show you
there's a little uh
kind of a video of how it works i'll
walk you through it
understand botox and those type of
medications
the effect you're getting is from
decreasing muscle movement only
and that's why when you're going to get
it and people say do i need botox or
filler
very common that people ask no you need
your botox like products
you need your filler your bio
stimulators your pdo threads and
your chemical peels lasers and rf micro
needling
it all works in concert together to
rejuvenate
the all-important aging rate and aging
process
let's look at this animation i'll walk
you through it
so if you look here this is highlighting
the glabellar
complex where the 11s are or those two
lines that go up and down
some people have a single one it is an
injectable there are topicals
on the way and that are talked about
these are the depressor muscles so
imagine if you stop those
um including the procerus and the medial
lateral corrugators
you will then get a lift now these
there's different
botulinum toxin type a's those are the
most common ones
on the market definitely the only ones
really used in this country
and there's the frown complex in
question now if you see this
the light going down that path that's
the nerve what you see
contracting is the muscle so it stops
that muscle ball that involuntary muscle
contraction now let's look at what we
call the synapse
where the nerve goes to the muscle here
you see those vesicles with the yellow
dots inside
those are going to release what we call
a neurotransmitter
in this case acetylcholine and that
is a messenger to the muscle to contract
now enter the botulinum toxin type a
those vesicles through snap cleavage
protein
are not allowed to exit for
as we know about three months so they do
not
exit the cell when you don't have the
neurotransmitter
telling the muscle to contract could be
a bicep
could be a calf muscle for spasticity
in our case it's typically the
corrugator frown complex
the frontalis the lifting complex the
orbicularis
oculi around the eye orbicularis oris
around the mouth
depressor anguli ores turns the mouth
down
masseter those are the main ones we
target and then the platysma
for the neck bands those are really
common ones used
for treating stopping voluntary
muscle movement so you see how it works
through that neurotransmitter process
i want you to understand that because
there likely will be a case made
that the newer six month one works
through a different mechanism
i've seen the studies i've heard the
story i'm not going to really present it
to you it's not fda approved yet it's
coming down the pike do you want a
longer lasting toxin
someone sent a picture to me the other
day of a dramatic brow droop
that would last six months instead of
four i use
high dose dysport and botox now
i typically use enzeme and use higher
doses than botox
anyway but definitely it costs more
money for the patient
but i get more longevity because i
shrink it down
more the muscle after piece it does last
longer there are ways
let's see what the story is uh from
revamps
therapeutics when it gets fda approved i
know what it is and it has to do with
the mechanism of action being different
the complete story will talk about
do you even want a longer lasting toxin
what would you pay for that now you know
the mechanism
stay tuned here we're keeping your skin
and body
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