These are the top-viewed research articles
from JAMA Network journals published October 1, 2020, to September 30, 2021.
Effect of Ivermectin on Time to Resolution of Symptoms Among Adults With Mild COVID-19
In JAMA, findings in this randomized trial, which compared the use of ivermectin to placebo
for treatment of mild COVID-19, do not support use of the drug.
SARS-CoV-2 Transmission From People
Without COVID-19 Symptoms This decision analytical model published
in JAMA Network Open estimated that more than half of COVID-19 transmission
in the community likely occurred from asymptomatic individuals.
Effects of Psilocybin-Assisted Therapy
on Major Depressive Disorder This randomized clinical trial in JAMA Psychiatry found
that psilocybin-assisted therapy was efficacious in producing large, rapid,
and sustained antidepressant effects in patients with major depressive disorder.
Myocarditis Following mRNA COVID-19 Vaccination in Members of the US Military
In JAMA Cardiology, this case series described myocarditis presenting in 23 male patients
after COVID-19 vaccination within the military health system.
These episodes occurred against the backdrop of 2.8 million doses
of mRNA COVID-19 vaccines administered.
Maternal and Neonatal Morbidity and Mortality Among Pregnant Women With
and Without COVID-19 This multinational cohort study published
in JAMA Pediatrics showed higher complication and death rates in women
with COVID-19 compared with those without COVID-19.
Their newborns were at greater risk of neonatal complications.
Evaluation of Cloth Masks and Modified Procedure Masks as Personal Protective Equipment.
This comparative study in JAMA Internal Medicine examined the fitted filtration efficiency
of 7 consumer-grade face masks and 5 medical procedure mask modifications.
Delayed Localized Hypersensitivity Reactions to the Moderna COVID-19 Vaccine
In JAMA Dermatology, this case-series study described the clinical course
and histopathologic examination findings
for delayed localized cutaneous injection-site reactions to the Moderna COVID-19 vaccine.
Neurologic Involvement in Children and Adolescents With COVID-19
or Multisystem Inflammatory Syndrome In this study published in JAMA Neurology,
COVID-19-related neurologic involvement was common in hospitalized children
and adolescents and mostly transient.
Progression of Myopia in School-aged Children After COVID-19 Home Confinement
In this cross-sectional study published in JAMA Ophthalmology,
a substantial myopic shift was noted after home confinement due
to COVID-19 for children aged 6 to 8 years.
Association of COVID-19 Vaccination and Facial Nerve Palsy In this case-control study published
in JAMA Otolaryngology-Head & Neck Surgery,
no increased risk of facial nerve palsy was seen following vaccination
with the Pfizer-BioNTech BNT162b2 vaccine.
Cancers and COVID-19 Risk, Disparities, and Outcomes In this case-control analysis
of electronic medical records from 73.4 million unique patients, which was published
in JAMA Oncology, those with a recent diagnosis of cancer were at significantly increased risk
for COVID-19 infection and its adverse outcomes, especially in African American individuals.
Survival After Breast Conservation vs Mastectomy Adjusted for Comorbidity
and Socioeconomic Status In JAMA Surgery, in this large cohort study of patients
with breast cancer, survival was significantly better after breast-conserving surgery
than after mastectomy despite adjusting for 2 pivotal confounders,
comorbidity and socioeconomic status.
Association of Wealth With Longevity in US Adults at Midlife In this cohort study
of US adults in JAMA Health Forum, net worth at midlife was associated with longevity,
and this association was unlikely to be merely an artifact of early experiences
or heritable traits shared by families.