Hi, I'm Cathy, with LevelUpRn. In this video, we are going to talk about acute
kidney injury or AKI, and if you have our LevelUpRN medical surgical nursing flashcards,
definitely pay close attention to the old red text on these cards because there's going to be a lot
of important points that you definitely have to know. At the end of this video,
I'm going to give you guys a little quiz to test your knowledge of some of the key points I'll be
covering in this video. So definitely stay tuned for that. Acute kidney injury or AKI
is the sudden loss of kidney function that is typically reversible. This is differentiated
from chronic kidney disease, which is the gradual, irreversible loss of kidney function.
So there are three general underlying causes of acute kidney injury. One is prerenal AKI. This
means we have decreased blood flow to the kidneys, and this can be caused due to sepsis, shock,
hypovolemia, as well as renal vascular obstruction. Then we have intra renal AKI.
That's where we have damage directly to the kidneys. And this can be caused by physical
trauma, hypoxic injury, or chemical injury due to toxins or medications. For example, Gentamicin
is very hard on the kidneys and can cause intra renal AKI. Then we have post renal AKI.
This is where we have mechanical obstruction to urine leaving the kidneys. This can be
caused due to a stone, a tumor, or BPH, which is benign prosthetic hyperplasia.
So this causes urine to back back up into the kidneys, which leads to impaired kidney function.
Let's now talk about the phases of acute kidney injury. There are four. The first is onset,
so this is when kidney injury occurs from one of the reasons we just talked about. Then we go
into oliguria where the patient's urine output drops dramatically. So they may only urinate
less than 400 milliliters per day. And that excess fluid is going to back up in the body,
which is going to cause edema and hypertension. Also, during this time, we are going to have
electrolyte imbalances, such as hyperkalemia and hyponatremia. so that hyperkalemia can cause
dysrhythmias and that hyponatremia can cause seizures. We're also going to have an increase
in creatinine as well as BUN, and metabolic acidosis may be present as well. From oliguria,
we're going to go into the diaresis phase. So now the patient's urine output is going to increase
greatly, so they may urinate up to five liters per day. And we're going to start to see improvement
in lab values such as creatine, BUN, and those electrolyte levels as well. Then from diaresis,
we go to the recovery phase where we hopefully have the normalization of creatinine, BUN,
as well as GFR. For a subset of patients, their BUN and creatinine levels may never fully recover
and some patients may end up with chronic kidney disease, which will require lifelong treatment.
In terms of lab abnormalities that will be present with acute kidney injury. A couple of those I
mentioned already, which include hyperkalemia and hyponatremia, we will also see hypercalcemia
and hypermagnesemia. Metabolic acidosis will be present as well as anemia because the kidneys make
erythropoietin, which stimulates red blood cell production, if the kidneys are damaged
are not working correctly, they are not going to be producing that erythropoietin,
which is going to cause a drop in red blood cells. And then, of course,
we're going to have an increase in creatinine and BUN because of the kidney dysfunction
that is occurring during AKI. In terms of treatment. We want to identify and treat any
underlying cause, such as dehydration or a kidney stone. In terms of medications that can be used
during AKI, we can use diuretics to help get rid of excess fluid. We're going to want to provide
medications to bring down those potassium levels so we don't end up with dysrhythmias, so that can
include calcium gluconate and then we can provide antihypertensive agents as well. The patient may
require dialysis during AKI. In terms of nursing care, we want to implement seizure precautions
because of the risk of seizures that comes with hyponatremia. We're going to monitor our patients'
eyes and nose and their daily wait. And then we need to make sure they reduce or restrict
their potassium intake, sodium intake, phosphate intake, as well as magnesium intake because of
those electrolyte imbalances that we discussed. All right, it's time for quiz. Three questions
for you. First question; shock or sepsis can cause what type of acute kidney injury?
The answer is prerenal AKI. Question number two; name the four acute kidney injury phases.
The answer is onset, oliguria, diuresis, and recovery. All right, for the third question I want
you to tell me whether the following labs will be increased or decreased. So first one; potassium?
It will be increased. Second one; calcium? Calcium will be decreased. Creatinine?
Creatinine will be increased. Sodium? Sodium will be decreased. Okay, that's it for this video. In
my next video, we will talk about chronic kidney disease. So definitely stay tuned for that.
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