- Okay, real quick, Mike, I wanna talk about Dr. K
- Yes, Dr. Kharrazian.
- And the giveaway that we're giving away.
- We are giving away six different programs of his
from Hashimoto's disease, to gut health, cognitive decline,
auto immunity, and one on saving your brain.
We're also offering a 40% discount.
You can use the code name "BOBANDBRAD".
Everything is down below in the description box.
And so further ado, here's Dr. Kharrazian.
- Yep.
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- Welcome my friends to the Bob and Brad podcast.
My name is Mike Kenitz
and I'm a physical therapist assistant.
Our guest today is Dr. Datis Kharrazian.
Dr. Kharrazian is a Harvard Medical School trained
and award-winning clinical research scientist,
academic professor, and world-renowned functional medicine
healthcare provider.
He develops evidence-based models to treat autoimmune,
neurological and unidentified chronic diseases
with non-pharmaceutical applications.
His clinical models of evidence-based medicine are used
by several academic institutes and thousands
of healthcare providers throughout the world.
Dr. Kharrazian is an Associate Clinical Professor
at the Loma Linda University School of Medicine.
So without further ado, here is Dr. Kharrazian.
Let's talk about, what are some signs of brain inflammation
and what should someone do if they have that?
- Biggest sign of brain inflammation, is brain fog.
And brain fog is a term that's used where you just can't get
to your thoughts.
So you can't find the words you're looking for.
You can't get to the memory that you're trying to get to,
and you know, the best way people explain it
is this fogginess. It's just slowness.
And really, what's the mechanism behind
that is there's what's called
"impaired nerve conduction velocities."
So when there's inflammation in the brain, neurons,
that's the messengers from one neuron to the next,
that's called "nerve conduction", it just gets slowed.
So inflammation slows down nerve conduction.
Okay, so now soon as an inflamed brain
and their neurons are just slower, they're firing slower.
So now everything's hard, everything's difficult.
They can't get to the thoughts.
They can't think, they can't focus.
And if it gets bad enough, you can get depression.
Like most of the current research is showing
you know, severe, massive unresponsive depression,
is really brain inflammation.
And this brain inflammation also, not only shuts
down nerve conductance,
it disrupts neuro transmission signaling pathways
in multiple mechanisms.
It changes something called "plasticity potential",
where different growth factors of nerves get shut down
during this inflammatory state.
And it really sets up the stage for neurodegeneration.
So, your biggest clue you have great inflammation,
is you have brain fog
and you could have brain fog for various reasons.
You could have brain fog
because you have food proteins causing it,
the gut brain axis, right?
Because they're like that.
You could have brain fog because you have Hashimoto's
and antibodies producing against the thyroid gland,
also have been shown to bind to the brain, the cerebellum.
It gives cross-reactive antibodies, brain fog.
So the immune system flares up, you have that.
You can have a past head injury
and you had a past brain injury that turned
on these inflammatory cells in
the brain called "glial cells."
And now, you didn't sleep well for the past two days,
your immune system is dysfunctionally more set
to inflammation and now you have brain fog.
So, all these various things.
And if you have brain fog all the time,
where the sensation of your brain speed is
just getting slower and slower, then that's a problem.
And that's a indication for mechanisms
that can lead into neurodegenerative disease
at the very, and also for sure, depression.
- How long does it normally take
for the brain inflammation to resolve itself?
- It can resolve itself in hours.
It can resolve itself, it can never resolve itself,
depending on what's happening.
So within the brain, you have cells called "neurons"
and you have another group of cells called "microglial."
And these microglial, they're immune cells of the brain.
And actually the brain has more
microglial cells than neurons.
So the brain is more immune cells than brain cells.
Okay? And these microglial cells,
they're the ones that create inflammation,
but they can also turn off inflammation.
And they have a pathway called "M1",
which turns on inflammation
and a pathway called "M2", which turns off inflammation.
So some people, we all get things that cause inflammation
in the brain every single day,
for various mechanisms, things cross our blood brain barrier
on a regular basis.
They can turn on inflammatory responses,
but for immune system and our brain's health,
these M2 pathways turn on their anti-inflammatory
and you don't notice anything.
But sometimes the inflammatory load is so much,
like you get leaky gut and have so much inflammation.
You have dysbiosis, you have lack of micro diversity
and you get these bacteria that produce
all these inflammatory mechanisms that get
into your bloodstream and you can go up directly
to your vagus nerve and your brain gets inflamed.
And the M2 pathway doesn't have the resiliency
to turn 'em off. And now you have brain fog.
And maybe, might have it for a day or two.
And finally the M2 pathways kick in,
and then they can turn it off.
And maybe the trigger goes down
and combination of those two can take place.
So it's devastating for some people,
some people that have these neuroinflammatory responses,
they just can't function when they get
into that inflammatory state.
And sometimes for days and days and sometimes even longer.
- So I would like, when I got brain fog,
mine was due to like hypoglycemia, pretty much.
My blood sugars were, 'cause I was discovering
my fasting blood sugar was getting a lot more elevated.
So like, pretty much I just went, you know,
low carb and then it fixed that.
But, and that's just for me.
- Yeah. And that, you know,
you may have just had lack of fuel for your neurons.
So it may, you know, so you're not having nerve
conduction speeds turned now by inflammation.
You just may have had not enough fuel
to keep those neurons active.
- Okay.
- Yeah. So you may have just been hypoglycemic.
But you know, when you get, when you lose cognitive speed,
it's not always brain inflammation.
Sometimes it's exactly like you said, hypoglycemia,
or you have drops in blood sugar levels there.
But it's usually lack of blood flow, lack of glucose,
like blood sugar or an inflammatory response.
Those are the main ones that cause brain fog matter.
- All right. So where can people find you at
on your websites and where can I get your books?
- So, my website is "drknews", "d-r-k-n-e-w-s.com.
"drknews", 'cause my last name's Kharrazian,
and that's really hard to spell.
(Dr. Kharrazian chuckling)
So we use Dr. K News.
And then I do have free content on that,
including a "Gluten in the brain" book.
So there's a free online gluten brain book,
if you want check that out for listening.
And, we have lots of podcast and videos
and information, trying to educate the public
and the goal of the website is to, you know,
to educate the public and let them eventually know about
the books I've written.
I've written two books, one on the brain,
one on the thyroid.
And we have some online courses on the brain, thyroid
food sensitivity, food allergies,
to try to get information out to people.
But, hopefully it can be a good educational source
for those that are interested in these topics.
- All right.
Well thank you for joining us.
- Okay. Thanks Mike. It was a pleasure.
And, talk to you soon.
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