I've never played the original Plague Inc,
but I've seen a lot of requests for this
and this is actually a really popular video game.
For players wanting a quick game.
No one washes their hands, researchers, doctors don't work,
sick people give hugs.
Normal, 67.3% of people wash their hands,
doctors work three days a week, sick people ignored.
Brutal, compulsive hand washing, doctors never go home,
sick people locked in prison.
Mega Brutal, genetic drift impacts evolution,
doctors invest in research, random medical checkups.
I guess, let's do Casual just to get a quick game,
to learn how this bad boy works.
Name your plague, DM-V4.
(laughs) I dunno why V4 but now it sounds scary.
All right, you are a new bacteria.
To win you must evolve and spread across the world,
wiping out all humans in the ultimate plague.
Select start location.
Select a country to begin your plague.
When you select it with the R2 button,
you can see more information.
Pop the start bubble with R2 to confirm,
or select another country instead.
Use the left stick to move the crosshair.
Okay, world population 7.1 billion.
Where should we start this?
I feel like I don't want the plague
to kill anyone on the North-East coast of the United States,
so I won't start there.
You know what?
Lets target the motherland. (laughs)
Russia, population 160 million,
there is planes, there's ships,
it's rainy, it's snowy, lots of leaves.
DM-V4 has infected its first human.
Weak but used to cold temperatures,
it must evolve using DNA points to infect more people.
I've infected one person with zero dead.
There's airplanes flying all around.
Okay, if I do Blood 1, gives organism ability
to spread to blood-to-blood contact.
Water 1, pathogen can survive outside
in fresh, warm water.
That's definitely not good for Russia
cause there's no warm water.
Air 1 gives pathogen ability to travel on dust particles.
Common flea, no we don't want rodents.
Birds, insects, I say blood through blood contact,
that's probably the best for Russia.
Oh, symptoms.
Painful cysts containing pockets of the pathogen,
slight chance of bursting which can spread disease.
And that costs two DNA points,
I currently have three, let's evolve.
Woo, look at that evolving happening!
You have spent DNA points to evolve your disease
and more options have opened up.
Get more points by popping DNA and Biohazard bubbles
with R2 and infecting people.
I don't get--
Oh, I popped.
Oh, I just got DNA points!
Okay, time to make this a bloodborne pathogen.
Yeah!
Oh, this is gonna be bad.
Okay, DM-4 has infected hundreds of Russia,
increasing the chance that a infected person
will infect a healthy person.
Keep evolving your disease, cool.
See, I wanna go for Blood 2 because then
we can infect bodily fluids and get mucus membranes going.
It's gonna be like the flu.
We're gonna make DM-V4 like the flu but with cysts.
This is really weird.
Ooh, I like this.
If they can get an abcess, pockets of infected flesh
are painful and act as breeding grounds for the pathogen,
increasing infection sites, yeah.
Ooh, we got abilities.
Pathogen evolves, yes!
We need cold resistance, 'cause in Russia,
it's freezing, trust me on this.
I've never thought I would be so excited
about infecting the world.
DM-V4 has infected thousands in Russia.
People are being infected faster and faster, yeah.
22,000, 23,000, okay.
Oop, medicine in Norway slowing infection.
Norway's a wealthy country with high quality health care.
To spread faster, you may need to evolve
the drug resistance ability.
Norway, you got good health care but I'm coming.
DM-V4 is beginning to spread around the world.
Hit the Triangle button to see which countries are infected.
Wow, look at that, we got Norway, Finland, Russia,
Ukraine, Turkey, Iran, Kazakhstan, China.
I'm gonna create drug resistance
to make sure Norway doesn't start catching up to me.
I already got 2,000,000 infected.
DM-V4 has infected more people in the world than TB.
It is a very infectious disease.
My god, look at the country being wiped out.
21,000,000 people, two dead.
I've claimed my first victim.
This is making me happy for a really strange reason.
Russia is the first to instruct doctors
to begin research into a cure for DM-V4.
The more scary DM-V4 becomes by hurting and killing people,
the harder humans will try and cure it.
Remember this when evolving your disease.
Oh, no, we have a million dead as a result of my illness.
Russia exterminates pigeons, what?
What's happening in Russia here?
Oh my god, look at the government
is dispensing bottled water, exterminating rats,
face masks are being distributed,
exterminating pigeons, what do the pigeons do?
My god, Russia's dropped already $2,000 on medical research.
That's not that much money, Russia, you could do better.
Oop, oop we got a case in the US!
Do we have a case in the US?
Oop, 17 infected.
All right, poor Russia is just all red on this map.
Greenland is about to wiped out.
Am I gonna destroy the population of Russia right now?
90% of their population's infected.
10% of their population's dead.
All hospitals are closed, they're using mass graves.
Jesus.
Oh, it's spreading into Africa and Australia.
Okay, I think I'm taking over.
I think the world's about to end.
Killed more than the Black Plague.
We've killed over 75,000,000 people.
Tip: Fight the Cure.
There are two ways to fight development of the cure.
Evolve aggressive symptoms to destroy countries,
more noticeable,
or evolve cure resistance, less noticeable.
(gasps) The cure in the US for DM-V4 is 25% complete.
No way.
(gasps) Research doctors all over the world
are completely focused on developing a cure.
No.
Indonesia is leading the global cure effort.
They started to send research teams.
Pop blue bubbles to destroy their research.
Stop doing research.
They may find a cure.
This might be problematic.
'Cause I think I infected all the countries
and I think I was too aggressive with it.
Oh, the cure of the world is 70% done.
You know what I need to do?
I need to create warm resistance so it can spread to Africa.
Let's see if I can get it to spread to Africa.
The cure is 95% complete.
I've only killed 362,000,000 people.
The cure for DM-V4 is finished
and it's being deployed worldwide.
Oh no, look at the number of infected.
The world has survived a devastating plague
and will soon eradicate DM-V4 forever.
Large numbers of people have died
and the world is changed forever.
No, this is so sad.
No one's officially infected.
DM-V4 has been eradicated.
There's no way I'm gonna finish playing this game
without DM-V4 taking over the world.
(car horn resounds)
It's the most obnoxious honk in the history of honks.
DM-V5 is gonna be fire.
(fingers snap)
Yeah. Extra yeah.
Edit name.
DM-V5. (laughs)
We're going right for the US.
'Cause I know the US weakness.
I know the way to make this happen.
I have my white coat.
We're gonna make a cure impossible.
That's the goal.
This is all gonna be about fighting the US ability
to create a drug.
I already know the strategy.
We're gonna keep the symptoms mild,
keep the resistance on high, ain't nobody stopping us now.
I feel like that's a popular song.
♪ Ain't no stopping us now ♪
Boom, demonetized.
Genetic Hardening, yes.
Look, see, no one's even ready for this.
They think they're gonna cure it with their money.
Ain't no money gonna stop us.
'Cause I'm gonna genetically harden
this medicine beyond cures.
Bacterial Resistance 2, yes please.
Penguin spontaneously combusts in zoo.
Hmm?
Kinda getting hot with this lab coat, but it's okay.
Honestly, the eyeglasses help the most 'cause I can see.
Oh no, let's do Bacterial Resistance 3.
Bacteria survives in all climates.
Minor disease spreading.
In a normal checkup, a doctor in the USA named Dr. Mike,
I'm just kidding,
found a new disease which has been named DM-V5.
It appears mostly harmless but must be investigated.
USA starts to work on cure.
Okay, US, I see you.
Look at this, Genetic Hardening.
Good luck, DNA.
US, with your research dollars.
Okay, so it's spreading pretty quickly.
The deaths are gonna skyrocket if I do pneumonia,
but if you have a lot of deaths,
then they're gonna put more money into the cure,
so I don't wanna do that just yet.
You gotta be strategic if you want your virus
to destroy the world.
Okay, here we go, this is where I'm gonna strike.
Transmission, you ready?
Let's do Insect.
Oh my god, that Insect thing is gonna put us over the edge.
Oh yeah, oh yeah.
Okay, let's do another Insect.
All right, we're definitely gonna take over.
Look at that spread in Canada.
Okay, let's do bloodborne transmission 2 now.
Oh my god, oh, we're gonna get the entire world
infected with this.
More people than the common cold.
It's the ultimate infectious disease.
Huh, they're 1% to a cure, good luck.
Vomiting, boom, let's hit 'em with the vomiting.
Let's hit 'em with the pneumonia.
Watch the number of dead skyrocket right now.
Look at that, 36,000, 95,000 dead.
Let's put paranoia in there, let's do seizures.
How about we do a little genetic reshuffle?
Research doctors all around the world
are completely focused on finding a cure for me.
Oh no, the cure's 50% complete.
I can't lose this again.
Oh, the cases in Greenland are spreading.
Look at that, look at that, look at that, look at that.
Ahh, that's so good.
Oh my god, yes.
There are no healthy people left in the world.
We all have DM-V5, yeah!
Oh no, they're at 83%, oh no.
Come on, with all these symptoms
how are people not dying faster?
Projectile vomiting, okay, cool, cool, cool, cool, cool.
Never thought I would say that.
6.2 million people are dead, 6.3 billion, 6.4 billion.
This is the most evil I've ever been in my entire life,
but I'm here for it.
27,000,000 people left alive.
7.1 billion people dead.
Oh my god, it's to destroy humanity.
The last few humans know
that they are watching the end of history.
300,000 people, 200,000, 100,000,
80,000, 60,000, 50,000, 30,000.
I've never been so excited for humanity to cease existence.
5,000 people, 3,000, it's like New Year's.
I've killed everyone on Earth.
DM-V5 has successfully eliminated all life on Earth.
That's what I was talking about.
Just needed my stethoscope, my lab coat, and my glasses.
If you enjoyed watching me play Plague Inc,
I'm sure you're gonna enjoy this playlist
of me playing other games.
And if you have suggestions,
drop 'em down below in the comments.
Stay happy and healthy.
(intense music)
Pah!