this is how you 2000 yeah oh my god and
10 after 12:00 and this is me reading
this going to the Y trifold cover of a
mirror here and two hours later this is
how I talk now notice how my mouth seems
to be moving a whole lot less there's no
straining there's no spasming big change
from me oh man
so there's something in the ingredients
in ambient that allow me to speak and
relax and you know I can actually talk
like a normal person which is great
ambien is a drug with many faces and not
all of them are sleeping best known for
treating insomnia causing bouts of
uncontrollable nocturnal binge eating
and endowing Tiger Woods with enhanced
sexual abilities ambien has another
property one that may very well change
medical history by normalizing
neurological functioning in damage to
brains in 1996 24 year-old Louie V Owen
was struck by a truck resulting in an
injury that left him in a persistent
vegetative state then in 1999 Louie's
mother decided to feed her unconscious
son a crushed ambien tablet through a
straw to reduce involuntary muscle
spasms in his arms to her amazement
Louie spontaneously regained
consciousness opening his eyes and
speaking for the first time in three
years and so I decided to visit Louie in
South Africa and learn more about the
ambient effect
I met with dr. Walley now who is known
louis since he was a child and saw louie
through his zolpidem metamorphosis
is me
Louie VC so you can do 200 me Jeff
do you know that you were the first
person in the whole world that took this
soul knocks yes it's still working
oh yes yes it's still working that was
the picture of how he looked before his
accident though he was 25 years old and
he was working at the Far Eastern
hospital switchboard operator and he
borrowed a bicycle from one of the
frames thing and that knotted about how
fast 11 he somebody was outside market
and they were calling me there was an
accident a bicycle accident
so they took me through to the ICU and
he was lying there beneath it was twice
as big as it used to be cause she was
brain damaged it was you know for for a
mom to see your son like that that's bad
New Year's in the summit colonel he
never said one single word nothing he
swallowed the time nothing we were
standing there myself and my husband and
I think it was after 20 minutes I just
heard things he didn't say anything you
just do that Edith this is the past
putana sake
we heard something and he said I mean
it's nothing and after about 40 minutes
and I said do we can you hear me and
then all of a sudden I just cried and I
find up to one family I said do we came
to she tell me the story I said it's
totally possible this doesn't happen
these things in my time when a brain is
dead it's dead so I came out on the
Sunday we gave him the tablet and I we
understand me and the family was
standing down on the bed and I saw also
the twinkle in the eye then you started
with all your own Watson's name he is a
rehabilitation Louie had these three
tablets of day he's on half twice a day
now he's IQ ten o'clock before he gets
his tablet
he's 70 and after the tablet two hours
after the half of the ability his IQ
goes up to 90 what other sorts of brain
injuries can be treated with ambien what
we have treated in what we are treating
as multiple sclerosis dementia
Alzheimer's cerebral palsy near
drownings we've got the problem we've
got the answer that we haven't got the
in-between we didn't know we didn't know
where to start or how to start until
there are fees to be fully honest on
that one there on the explanation part
on the more scientific water in 1999
Ralph Klaus stumbled upon an article
about the miraculous awakening of
Louisville and decided he wanted to
study the effect further by imaging
changes in cerebral perfusion before and
after ambien
what happened in the grease brine was
that the way these big areas that were
not functioning at all it's a kind of
dark areas and then after stopping him
these regions all normalized so they're
like a day/night difference this this is
Louisa brain his original state before
his operative and you could see this
large decreased uptake in the parietal
region in which normalizes after self
again and see whatever is their fears
about 40% of normal comes to 20% of this
often and so you have these two
phenomena you have the excited toxic
effect which is the same time is
stabilizing the market environment so he
was almost his suicide cells that offer
themselves with a great and good and you
have the other cells which are
influenced by the governor which down
regulate and survive the exact
biochemical mechanism of ambience
therapeutic effect and brain injury has
yet to be identified but dr. Klaus
theorizes the gaba a ion channel
undergoes an epigenetic change after
brain trauma causing an unregulated
influx of chloride ions that suppress
neuronal activity so you have really two
just different gaba-a receptors here
you've got the normal GABA receptors
which you know it induces the sort of
sleepy change then you have the abnormal
receptors which has gone through all
these these crisis after brain injury is
not the same as this original receptor
anymore
it is a receptor which is super
sensitive and zolpidem through
distorting this receptor normalizes it
again and when that happens then the
brain becomes less suppressed obviously
and you see these changes on the brain
SPECT scan or metabolic change and you
see the changes clinically
so something works anywhere in this in
this in this spectrum basically because
every way in the spectrum you have you
have this this part that is damaged with
that if you like non reversible entry
flow
you've got this parallel area of
dormancy this is Jonathan Poole
he's a bank manager in Guildford
actually and he had struck an obvious
joke yet the promise understanding
people here who suffers from order to
diagnose her so he hears sounds and his
words but he doesn't know what they mean
dr. Klaus and I went to meet Jonathan
Poole the banker who lost his numbers a
sudden stroke at the age of 56 left pool
with a lesion in his left temporal lobe
that interfered with his ability to read
and understand language dr. Klaus
prescribed Poole zolpidem and I wanted
to see the effects firsthand shocking he
was saying very well but if class talked
to me I would not have half of what
saying because this this year is doing
something funny inside the brain
so so when I talk to it like that I talk
quite well but right here from this word
my words will come very short the
ceiling though interesting and if you
see dr. Klaus is lips while he speaks
are you then able to interpret the words
most of it but if it's a new word like
names numbers people I don't hear and
this is written down in front of me and
then I might have a chance to say it she
took me nearly six months to hear my
wife's name which is sue what Susan but
it was someone on the phone and just
give a name of Sue it so it would
it means no name to me at all
it's been very much more easy since he's
been under zolpidem I wouldn't let
anyone take him off it
I really wouldn't because it makes life
so much easier for us all but before his
stroke jonathan was very articulate it
was very good with figures and things
like that since his stroke although he
can obviously now speak properly he does
still have problems with words very bad
with numbers particularly over the
telephone so quite often if he gives me
a message over the phone I know I have
to check it first because it's quite
possible he's got the words wrong
numbers wrong could we test the effect
dr. Klaus would you just sort of more of
this complex now there's a pitch I give
you five numbers right and then you you
say them on once I said yes yes now he
will see something possible okay yes 580
353 630
377 something 7 291 250 151 833 and I've
lost it I had I think I was three but
I've lost I didn't hear it quickly
enough so that was I've lost that one
171 okay even though Jonathan Poole had
already taken one ten milligram ambien
that morning the effects had diminished
by the time we arrived so he asked him
to take a second allowed sixty minutes
for the drug to reach optimal
concentrations and tested him again to
see if his understanding of numbers had
improved
641 six for one seeing the positive
effects of ambien on pool and Louie was
extremely impressive but there was still
the matter of Thomas Rowe a voice-over
artist who's one of the most dramatic
responders to the ambient effect that
was fun
in 2009 Rowe played a tragic visit to
the dentist one that left him without a
wisdom tooth and without the ability to
speak Rose career was ruined and he was
forced into retirement at the age of 52
one night he stayed awake on ambien to
find his voice had returned this is how
I talk now
and so I traveled to Orlando Florida to
meet Tom at his former studio sunspots I
spent years here
I was the voice of the Circuit City when
they were in business for six years I
did a lot of nice on it all ends
tomorrow that kind of stuff when I hear
myself or he like those big ice it it's
hard to believe I know
oh I was like a country song I lost my
career and then my dog died and what can
I do other than if there was a job for
someone with a speech disorder it's not
so much I want to go back behind the mic
again but I'd like to speak without pan
for the Royal pork for someone that
hasn't experienced anything like this
could you describe what it feels like
muscular Levon if you took her bottom
lip and pulled it hard as hard as maybe
it's hard isn't it
out and then cook your neck and grab
that and pull it back and the forehead
and pulled up and your cheeks and pulled
back I take the and in and I feel
everything her long only drug the work
she's hand in in order to test
ambiens therapeutic effect I asked Tom
to promote a Chevy spring event the gym
that is every spring event I'm more
patient $8,000 off your next Tahoe lure
I can hear me and the inside me
breathing that I know the rhythm I know
the bomb throwers me unlike many brain
trauma patients who don't experience
ambience typical hypnotic effect Tom row
started to become inebriated in a world
of giant monkeys only one man will stand
above the Apes tonight on WGN and we
need to arm them with the skills the
knowledge and the confidence they need
to be victorious yeah that's pretty good
it's just fun you can't deny them you
know it's working yeah it's not there
yet it's working while General Grant was
busy with his father's there was
something going on deeper south
the Sun had set and although Tom had to
fight a strong urge to sleep
his voice was back and couldn't be
stopped
that's no different than what was done
when I was there and now with the ambien
in full effect
I once more asked Tom to promote a Chevy
spring event it's the gene master Chevy
spring event and we're taking a
thousands of dollars off your next Tahoe
that's right get a brand-new 2010 Chevy
Tahoe at Jean Messer Chevrolet and we'll
take $8,000 off MSRP it's time for our
new Chevy Tahoe from Jean Messer
Chevrolet Wow Wow like being alive when
I do that what started out as a
serendipitous discovery may now
represent one of the most important
interventions for brain trauma with time
and medical research
who knows what the future may hold we
try to push along this research on
zolpidem all the research that you do is
actually just art of interest in
goodwill of people who are trying to
find out what's going on it's just
scientific curiosity really these
insomnia trucks are not optimized for
passion of brain damage and therefore
there is a lot of money to be made but
if people develop this and optimize it
specifically for for people with brain
damage now myself get it on it's it's
such a wonderful thing how can we leave
it I don't think it's fair to any
anybody or any population or any race or
anything to say leave it with what we've
gone through now
you