Recently a discussion got started between a couple of viewers: Old Alabama
Gardener and Ken Rache about pqq . Old Alabama Gardener mentioned that he'd
been taking it for a while. He's taking the life extension version and Ken Rache
was asking if it works. As is usually the case with supplements, Old
Alabama Gardener had to say, "Look I don't know. I can't tell ." Especially
supplements associated with the mitochondria ( it's hard to tell if they actually worked). I had not investigated
PQQ that deeply. I started looking around based on reading that discussion and
found a very interesting article actually it was interesting enough to
where ... - I had not been taking PQQ. after reading this article I went to Amazon
and ordered some. Now why ? well first of all two of the biggest attractions for
me were number 1 the quality of the journal - this was nature magazine it was
recent - June of this year and here. Look at the title, PQQ ameliorates cognitive
impairments. Then they get into some of the technical stuff the
d-galactose is a model of senility which is created in lab rats they also talk
about how does it do it? a couple of ways number 1 is an antioxidant way
and another one is a signaling pathway in terms of gene expression so let's
talk about the a couple of points here next
so pqq may influence the generation of pro-inflammatory mediators including
psycho cytokines and prostaglandins during the aging process so let's go
back and talk for just a minute about the aging process
within the brain as well as other tissue. You may remember I just did a recent video
on mitochondria and aging mitochondria is where we use oxygen to burn
carbohydrates fats proteins. We burn those by adding oxygen to
them - when you add oxygen to something it's called rust or burning
and you also get things like reactive oxygen species. That's where all of this
discussion about reactive oxygen species and oxidation comes in actually it
appears that we lose our mitochondria in the aging process because the
mitochondria start getting burned up by all of this peroxide. Most folks in the
baby boomer boomer generation remember when we were teenagers kids used to use
peroxide to take the color out of their hair until they realized how badly it
burned the hair well that's going on on a regular basis inside ourselves
associated with the oxygenation within our mitochondria in fact use of this
glutamate , The D-gal here is is a way that that they demonstrate.
it's a lab model for showing increased or early aging. you do have other Pro -
inflammatory mediators. What does that mean? You start getting inflammation and
some of the mediators are cytokines. What does that mean ? cyto means cell kines
means chemicals that attract. so these are chemicals that attract. as
you start burning tissue around that mitochondria you have chemicals that
attract inflammatory cells - immune cells - prostaglandins are also involved in it
as well. They saw something else that was very interesting in a previous
study that they did they saw that pqq statistically enhanced superoxide
dismutase again another huge word but it's all related to this item superoxide
dismutase is basically just a protein that we've developed as mammals to
combat this reactive oxygen species this peroxide what it does is it it busts up
peroxide before it can burn too much tissue in fact what they've done in labs
is .... they have genetically altered mice to where they don't have
superoxide dismutase, the gene to create it. Those mice developed early
senility very similar to the mice that they chronically feed levels of
glutamate. So again same process going on - you're not handling all of the the
reactive oxygen species the oxidation that's going on around the mitochondria
it's burning up your neurological tissues your brain so that's a couple of
the mechanisms that they're talking about here that's when they get into the
upregulation of expression of PAKT -
basically what they're talking about is we bring that oxygen in. we (use oxygen to
burn carbohydrates fats proteins) - by combining it with the oxygen ...
combining anything with oxygen is rust or inflammation or burning it some of
the byproducts can be peroxide we that peroxide burns the tissue - starts
burning tissue around the mitochondria and damaging and even destroying cells
we've developed some countermeasures for that like superoxide superoxide dismutase -
which will go in and and hit that degrade that peroxide early
but now they're saying they've found a supplement that will actually
do that. I'm not a huge believer in supplements and here's why
lifestyle - by far - has the biggest impact on our health. you can't
supplement your way out of a bad lifestyle you just can't do it but as
you get older and things start wearing out anyway sometimes it's helpful to
have a little help so I've gotten more interested in supplements recently.
well I won't go on about supplements . so here's the other
thing I mentioned there were two things that attracted me about this study one
is the the journal that it's in very highly respected journal the other is
the dramatic results that they show. Now here I'll go through a few slides on
this showing the images of these dramatic results .... let
me explain something here. This is spontaneous alteration in other words
this was where mice just started they had learned their maze
how to get through a maze but mice that were fed glutamate on a regular basis
started just doing weird stuff taking wrong turns unpredictably so these were
the control mice the glutamate mice started having problems
these are pqq mice they didn't have a problem and these last group were the
glutamate mice after you fed on pqq so in other words you actually got
improvement in the cognitive performance of ... aging mice by giving
them PQQ. This was another parameter .this was looking at latency in other words
how long they remembered how to do this again the glutamate aging mice didn't
remember is long pqq mice not that much of a significant difference but if you
fed the pqq back to the glutamate treated mice you started to get that
improvement again in cognitive performance
and yet another parameter of this cognitive performance here's looking at
error rates again same thing once you increased error rates with glutamate
once you added the PQQ back to the glutamate it stopped the the error rate
again same thing with some other things so they said they went back in and these
these results are not so much to do with the cognitive performance like the
others these results have to do with indicators of inflammation and sure
enough MVA reactive oxygen species which we've been
talking about and you hear a lot about they looked at those as well and again
so you see huge increase in reactive oxygen species in the glutamate fed rats
and it's knocked out again when you add that pqq again similar results with T-
AOC and MDA which were other indicators now I'm going to take a digression for a
second and I'm going to introduce myself and the channel. I've had plenty of folks
discuss it. I know some folks don't like it most folks sort of grin and bear it
and some even appreciate it here's the reason that I do this a lot
of folks see videos just out of the blue they've not seen any other videos from
the channel they need to know what the channel,s like to make a decision, " well
this may be an interesting video, but do I want to go look at others in the area
and what's the channel all about?" so briefly my name is Ford Brewer I
started off my career as an ER doc got very passionate very quickly about the
fact that most disease and disability is preventable
there wasn't much place to learn that back over 30 years ago when this was
going on with me Hopkins was one place I went there and they had a great program
in clinical prevention I loved the (preventive medicine) activity &ended up running
the program there but left to go out into the real world and have spent
over three decades helping large primary care Doc's - 800 Docs or more focus
on preventing disease instead of waiting until disease happens after a career of
doing that and seeing my share of patients as well it's always frustrated
me me that more people were not involved in this prevention conversation. So
that's what this channel is abou. it's about getting that conversation about
the science of prevention out there getting people less dependent on cures
because cures don't work nearly as well ask.... just anyone you know
that's had a heart attack or a stroke so back to some discussion on this article
and then we'll we'll end it up . as I said earlier D-gal or glutamate induces
changes which resemble the natural aging in animals like cognitive dysfunction
oxidative stress neuro degeneration it's been used as a lab rat model for aging
and senility it causes the cumulation of reactive oxygen species in vivo meaning
in the red itself not just in the lab that would be in vitro it's the critical
excitatory neurotransmitter now this is an interesting part I haven't covered
this yet and wanted to make a couple of points about that in fact just learning
this recently this article was a huge help in that area glutamate is a major
it's a critical excitatory neurotransmitter in the central nervous
system now why is that important ? it's that critical maybe there's some
significant association with critical ongoing excitation of our brains and
this oxidative stress. in fact it is the excited it's an excitatory
neurotransmitter neurotransmitter means a way for the brain to communicate
something from one cell across the synapse to the other cell you
know there are synapses - or connections between cells. IN the cell, during
the excitation, it goes electrically. But then there has to be a transmission
from one cell to another. that's a neurotransmitter. Depression
drugs work by impacting the neurotransmitters involved with
depressio. and glutamate is involved in excitation in 90% of the pathways. So
what they're saying is - (and here's where the the dot connection comes in it's
like oh you know what?- we associate chronic mental stress as a way of
aging quickly. Well here's a clear biological model for that. Again so
what they're discussing is they've just they've done previous research which has
supported this activity this research does as well saying that PQQ does
actually decrease that entire oxidative process the inflammation process and
they go into some discussion here as you remember from my previous coverage of
inflammatory markers it decreased inflammatory markers decreased oxidation
and it decreased the excitation. This one goes into the issue of superoxide
dismutase and I'll just cover that briefly. It gets
a little bit geeky. But it's consistent with this these recurring
themes that superoxide dismutase again is there are some rats that have
been genetically bred to know no longer have superoxide dismutase
those rats get old fast and you don't have to remember the term superoxide
dismutase but what you didn't need to remember is how do they get old
those rats can't handle the peroxide the other oxygen radicals that are created
by the mitochondria in their brain. Again, a lot of interesting dots
to connect. Those of you who have made it this far I really appreciate your
interest and as I said before I I'm gonna go get some PQQ. I'm not planning
on that replacing: keeping my weight down; continuing to do high intensity
intervals; monitoring my inflammation watching; my blood sugar's and my carbs.
Thank you again!