Jeff Huseby says, "do we know how long methionine lasts in the body? If I eat a half pound burger,
for example, and assuming perfect methylation, how long before I would need to replenish the
methionine pool, in other words a cycle count?" I mean, if you mean the methylation cycle, then
off the top of my head, I have no idea. I'm sure that math
could be done, but it's not something I know off the top of my head, but I would say, well, what I
can say much more easily is that that methionine is going to effectively run out in the...
as the fasting state emerges simply because...
I mean the methionine has many fates, right? And so if it all goes into the methylation pool, it's
going to be quickly either used for methylation or broken down in the CBS pathway. You are not
going to save methionine for the fasting state. Now, you might make proteins with it. You might
be able to break down those proteins in the fasting state and release methionine,
but you're not going to hold on to it within the vicinity of the methylation cycle to use
for when that burger stops feeding you methionine. So for all practical purposes,
when the burger is done digesting, and the last bit is absorbed, that methionine pool is running
out pretty quickly after that, because for the last two hours, while you were digesting it,
you were using whatever methionine and you got, either for methylation to recycle or
just straight up break down any excess into the CBS pathway. So that's how I would look at that.
Once the fasting state is emerging, the low methylation state is emerging.