In this video, I will define
the beyond use date or BUD
and provide an example
of how to calculate the BUD.
The beyond use date is when a vaccine or diluent
must be used before its expiration date.
While all vaccine and diluent have an expiration date,
only some vaccines have a BUD.
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Information about the BUD can be found
in the manufacturer's product information.
Providers may encounter instances when a BUD
will need to be calculated.
The first is when a lyophilized vaccine is mixed with
its diluent, or reconstituted, and then not used immediately.
For example, a patient or parent
refuses vaccine after it is prepared.
The Immunization Action Coalition or IAC
has a table summarizing the BUD
for lyophilized vaccines and their diluents.
Another exception is related to multidose vials of vaccine.
Most multidose vials may be used until the expiration date
printed on the vial unless contaminated
or compromised in some way.
However some multidose vials have a specified timeframe
for use once the vial is first entered.
Entered is defined as when a needle is inserted
into the stopper of the vial.
To determine the BUD,
first check the manufacturer's product information.
Depending on the product,
the manufacturer may recommend a BUD of either days or hours.
Once the BUD is calculated, it should be written on the vial.
The person who calculated the BUD should initial the vial
and properly store the vaccine.
Here's an example --
A multidose vial of Afluria brand of influenza vaccine
was first entered on October 1st.
The product information indicates the BUD
is 28 days after the vial is first entered.
The BUD for this multidose vial
of Afluria is October 29th.
The vaccine should not be used after October 29th.
Vaccines should not be used after their BUD
even if the expiration date has not been met.
Contact the immunization program and/or the vaccine manufacturer
as appropriate for your situation for vaccines
not used before the beyond use date or time.
This video is part of a series
demonstrating vaccine administration skills
and best practices.
The series is available
on the Vaccine Administration web page
on the CDC Vaccines and Immunizations website
at www.cdc.gov/vaccines