Jeff Huseby says, "I'm trying to figure out the best time to take TMG as a poor methylator
assessed from Strategene genetic repor, made by Seeking Health. The body only creates it
in the fasting state, right? Does that mean if it would be a waste of time to take in the fed
state or will the body has stored for later use of taken during the fed state? Sometimes it's
just easier to remember to take supplements with food rather than a random time between meals."
So TMG you normally yes, you would get it from oxidizing choline, and yeah,
that's going to increase in the fasting state when you're low in methyl groups,
but you are also going to eat TMG. And so dietary TMG also known as betaine
contributes to that. So I don't see why you wouldn't be able to store it for later use.
Yeah, I wouldn't worry about it, but, you can always test that, right? So
if TMG doesn't give you the homocysteine lowering response you're looking for,
then try in the fasting state, see if it makes a difference.
If you find that it does then, do what the results say. But as far as presumption, I wouldn't worry
about it. I would just take it with meals, it's easier. Thank you, Jeffrey for your question.