AT
AT THE
AT THE FOREFRONT OF THE FIGHT AGAINST KOBE 19. THEY ARE STARTING HUMAN TRIALS ON A
TREATMENT AND THEY'RE TAKING A
UNIQUE APPROACH. HERE TO TELL
US MORE. DR. R.J. TESSIE, CEO
AND CHIEF MEDICAL OFFICER OF
IMMUNE BIO. THANKS FOR BEING
HERE, DOCTOR. REALLY APPRECIATE
YOUR TIME. THANK YOU.
APPRECIATE THE TIME THAT YOU'RE
SPENDING WITH US AND YOU KNOW,
I HOPE EVERYONE IS STAYING SAFE
THEM WEARING THEIR MASKS. WE
ARE DOING OUR PART IN KEEPING
OUR DISTANCE HERE AND I KNOW
YOU ARE AS WELL. SO TELLS YOU
OR YOUR COMPANY. I KNOW YOU
GUYS HAVE BEEN FOCUSED ON
CANCER, ALZHEIMER'S DISEASE NOW
WHAT ARE YOU DOING IN
THE BATTLE AGAINST CORONAVIRUS
HERE? WELL, ACTUALLY WE ARE
FOCUSED ON INFLAMMATION IMMUNE
BIO WHICH IS A PUBLIC COMPANY I
M B IS AN IMMUNOLOGY COMPANY
FOCUSED EXCLUSIVELY ON
INFLAMMATION AND AS YOU KNOW IF
YOU'VE BEEN PAYING ATTENTION,
INFLAMMATION IS THE GREAT
BUGABOO. RIGHT. COVERED 90
THE VIRUS ITSELF REALLY DOESN'T
CAUSE THE CAUSE DEATH. I MEAN
IT CAUSES AN IMMUNE RESPONSE
WHICH CAUSE WHICH IS
INFLAMMATION. AND IT'S
THE INFLAMMATION THAT MAKES
PEOPLE SICK. YOU KNOW, AN
INFLAMMATION USUALLY WORKS TO
OUR BENEFIT. JUST THINK ABOUT A
SPLINTER. WHEN YOU GET A
SPLINTER, YOU GET A LITTLE BIT
OF SWELLING. IT GETS READ, IT
GETS WARM, IT GETS TENDER AND
THEN THAT HELPS YOU PUSH THAT
SPLINTER OUT. INFLAMMATION GOES
AWAY. THE PROBLEM WITH KOVAC 19
IS THE INFLAMMATORY RESPONSE IS
LIKE AN ATOMIC BOMB IT. WHEN IT
FINALLY TAKES HOLD IT GOES OFF
AND 20 PERCENT OF THE PEOPLE
THAT IT GET A COVETED 19
INFECTION GET AN INFLAMMATORY
RESPONSE THAT MAKES THEM SICK
ENOUGH THAT THEY HAVE TO GO
SEEK MEDICAL CARE AND IF
THEY'RE UNLUCKY OR HAVE WHAT WE
CALL CONE WHEN COMORBIDITIES OR
RISK FACTORS THAT PUT THEM IN
THE MOST SENSITIVE BEING HAVING
BAD DISEASE THEY END UP IN
THE HOSPITAL, MAY END UP IN
THE ICU, MAY END UP IN A
VENTILATOR AND WORSE. I DON'T
EVEN SAY NO INFLAMMATION IS
THIS IS THE STORY WITH COVERED
90. YEAH SO MUCH SO YOU GUYS
YOU'VE BEEN SAYING THAT WE
SHOULD BE TREATING KOBE 19 AS
MORE OF AN IMMUNO LOGIC DISEASE
RATHER THAN ONE THAT'S
NEUROLOGIC OR RESPIRATORY GOING
AS FAR TO SAY THAT EVERYONE HAD
IT WRONG EARLY ON. RIGHT.
ABSOLUTELY COVERED 90, YOU
KNOW. YOU KNOW, I'M A PHYSICIAN
.I WAS A TRANSPLANT SURGEON IN
MY PREVIOUS LIFE AND YOU KNOW,
SO YOU KNOW, I KIND OF WEAR TWO
HATS HERE. I LOOK AT IT FROM
THE PUBLIC HEALTH PERSPECTIVE
AND I SAID, YOU KNOW, THIS IS A
DISASTER BY ANY STRETCH OF
THE IMAGINATION. BUT WHEN I
LOOK AT IT FROM THE SCIENTIFIC
AND MEDICAL POINT, I'M LIKE
WOW, THIS IS REALLY INTERESTING
STUFF. AND YOU'RE ABSOLUTELY
RIGHT. WE HAD IT COMPLETELY
WRONG EARLY ON. WE THOUGHT THIS
WAS A RESPIRATORY DISEASE, A
RESPIRATORY VIRUS LIKE
IMPLEMENTS. REMEMBER BACK THEN
WE WERE THINKING ALL ABOUT OH,
WE DON'T HAVE ENOUGH
RESPIRATORS. AND THEN AS TIME
WENT ON SUDDENLY CAME ON OH,
IT'S AFFECTING THE KIDNEYS.
WE'RE NOT GOING TO HAVE ENOUGH
DIALYSIS MACHINES AND THEN
SUDDENLY IT WAS LIKE OH NO,
IT'S NOW AFFECTING THE HEART
AND IT'S AFFECTING THE BLOOD
VESSELS CAUSING CLOTTING. AND
NOW THE BIG DEAL IS THAT IT'S
AFFECTING KIDS, WHICH IS A
NIGHTMARE FOR THOSE FAMILIES.
RIGHT. AND IT'S AFFECTING
THE BRAIN. SO IT REALLY TOUCHES
EVERY ORGAN SYSTEM NOW AS A
CLINICIAN I LOOK AND SAY OK,
NOW WAIT A MINUTE, IT CAN'T DO
ALL OF THOSE THINGS. WHAT IS
THE THING THAT WHAT IS THAT
THING THAT KNITS THESE PROBLEMS
TOGETHER? AND WE BELIEVE AND
THERE'S A LOT OF EVIDENCE TO
SUPPORT THIS THAT THE PROBLEM
IS REALLY THE BLOOD CLOTS,
THE BLOOD CLOTS THEY CAUSE
THE LUNG PROBLEMS THEY CAUSE
THE KIDNEY PROBLEMS THEY CAUSE
THE HEART AND BRAIN PROBLEMS
AND THOSE BLOOD CLOTS ARE
BECAUSE OF ENDOTHELIAL
ACTIVATION AND INFLAMMATION
ENDOTHELIAL CELLS OR THE CELLS
THAT LINE THE BLOOD VESSELS.
THEY'RE USUALLY JUST SIT THERE
INERT. THEY'RE LIKE PAVEMENT OF
A HIGHWAY. YOU JUST ROLL ALONG
AND YOU NEVER KNOW THEY'RE
THERE. BUT WHEN THEY GET
DISRUPTED AND THERE'S TONS OF
POTHOLES AND THERE'S PROBLEMS
THEY FORM THESE BLOOD CLOTS AND
THE BLOOD CLOTS ACTUALLY BREAK
.AND THAT'S WHAT THE PATHOLOGY
IS. I BELIEVE WHEN THEY WRITE
THE HISTORY OF COVE AT 19 IT'S
NOT GOING TO BE A RESPIRATORY
DISEASE. IT'S GOING TO BE A
DISEASE OF BLOOD CLOTS AND
THE DISEASE OF BLOOD VESSEL.
DOCTOR REALLY HAVE A COUPLE
SECONDS LEFT HERE BUT I WANT TO
KNOW WHERE YOUR TRIALS STAND
AND WHAT'S NEXT IN THAT. SO WE
ARE ACTUALLY WORKING WITH
THE FDA RIGHT NOW. OUR GOAL IS
TO TREAT AND GET PATIENTS
TREATED BY AUGUST. WE'RE
TARGETING THE PATIENTS WHO HAVE
JUST ARE SICK ENOUGH TO REQUIRE
HOSPITALIZATION BUT NOT SO
SICK. THEY'RE IN THE ICU. OK.
OUR GOAL IS TO KEEP THEM OFF A
VENTILATOR, GET THEM HOME AND
KEEP THEM ALIVE. AND WE PLAN TO
DO THAT WITH A SINGLE SHOT ONE
DRUG, ONE DOSE OF COLOR WHICH
TARGETS THE CYTOKINE STORM TANF
THE CYTOKINE STORM. DR. TARZI,
PLEASE KEEP US ABREAST OF HOW
THESE STUDIES ARE GOING HERE
AND LET US KNOW WHAT KIND OF
SUCCESS YOU'RE HAVING. WE
APPRECIATE YOUR TIME.
EVERYTHING YOU'RE DOING HERE IN
THE FIGHT AGAINST KOBE 19.
THANK YOU, ERIC AND WE
APPRECIATE YOU GETTING THE WORD
OUT THAT WE NEED TO KEEP THOSE