One of the articles that this article referenced was the article on
caloric restriction. Before the video, I mentioned that one road led to another
led to another. One of the articles that this article referenced was
the article on caloric restriction. And many of us recognized this guy
Roy Walford. Not only is Walford Longo's mentor at UCLA, but one of the major
fathers of caloric restriction. He's the guy that went in with the team of what
15 people into a large terrarium in the desert in Arizona for about nine months.
And here's the pictures before that terrarium experience. Immediately on
coming out, he looks like concentration camp survivor. But then after a few months
later, after he's re-fed. And it's not that easy to tell from this view. But
even with this poor view, you can begin to see he's got more definition after
the refeeding episode and after having gone through that caloric restriction
event. As you start getting into things like the fasting mimicking diet, that's
one of the reasons that Valter Longo developed it. He said there's no question
the huge positive impact that fasting has in the human body. But number one,
when he was called and talked to Dr. Walford, when Dr. Walford was in this... do
you remember the name of that terrarium experiment? Biosphere. Yeah. He said
Walford was his advisor while he was in the biosphere so they had to do it on by
phone And he said, you know, gosh, there was a lot of frustration and anger in
there. And we all know you get grumpy when you run out of calories. So Longo's
view of this was let's see if we can trick the body into thinking that
there's some fasting going on and yet make it a little bit easier than having
to go through the experience that Walford
went through. So that's where you get to you get that. You know, Ford, that's
a great point about the difference between calorie restriction and
intermittent or fasting mimicking diets. And one of the points that the New
England Journal article brought out that I wasn't aware of is that the early
studies on caloric restriction in longevity of course were in a mouse
model and other animal models. And certainly, they proved beyond the shadow
of a doubt that it made the mice live long to restrict their calories. Yep.
What they didn't realize initially and what kind of calorie restricted, it's
going on the wrong path for a while. When you restrict the mice to a
certain number of calories, they end up eating all of those calories in about
four, six hours, right? And then they're fasting for the other you know 18 to 20
hours. And it really was the magic of that intermittent fasting that was more
important than the caloric restriction. Yeah, it's a good point. They brought it
up in there are you familiar with such in Ponda and Valter Longo's work in
that space? I really am not. It's very much related to this. They call it TRE-
time-restricted eating. Right, and basically, it's just closing that window.
It's just saying, okay, you know, in some of the worst examples of the modern diet
you know maybe even have a snack at midnight, get up whatever time you get up
5:30, and start with breakfast, and then have three meals a day and how many
snacks, plus you know other calorie sources in between. So what they're
saying is, whoa, stop that. And instead of going to 18 hours of eating and 6 hours
of fasting in a 24-hour day, close that down and get to 8 hours or even 6
hours of eating and the rest fasting. And that creates some of the metabolic
processes, the very positive metabolic processes that you were have referred to
a couple of times. It also creates some confusion because most of my patients
when they assume if already been down this path, they'll
say, well, I'm doing intermittent fasting which I've become to assume just because
that's what I usually hear. They're skipping breakfast occasionally. I'll
find someone who's skipping dinner. But usually, it's skipping one of those two
meals. And technically, you might say, well, that's time restrictive eating as
opposed to intermittent fasting. But again, you saw some of that same
interchange and use of intermittent fasting in the New England Journal
article as well.
The Louisville event was an incredible success. Many people didn't know that
that was our first attempt to coordinate the whole thing ourselves. And it was
better than we had had hoped. A lot of focus and people saying you know what I
know that we can deal with this together as a group.T there are other people that
I'm meeting here at this event that are doing the same things I'm doing and with
success. I don't have to be a doctor to know all this stuff. We are going to go
ahead and have another one on February 28th in the Hyatt Regency Grand
Cypress in Orlando.