In today's video, I'm going to talk about OTO-313, a potential cure for tinnitus.
Welcome, if you're new to my channel my name is Emily, I created Definite Hearing as I'm hard
of hearing myself. I wear two hearing aids and I love them so so so much. These are ReSound Enzo
3Ds. Without them, I can hardly hear at all, so I'm so grateful that every morning, I can wake up,
put them in and feel like I can hear almost anything in the world.
If you haven't already please like this video and subscribe to my channel. I look forward to
making more hearing loss related content for you. Alright I don't personally struggle with tinnitus
but I know a lot of people that do, which is why I am making today's video. OTO-313 or
OTO-313 is a drug that is currently in Phase Two of FDA testing, it could potentially be a cure for
tinnitus. This OTO-313 phase two test is testing whether or not individuals with unilateral or one
or single sided tinnitus, see decreases in their tinnitus symptoms. This test has a participant
pool of 140 individuals, males and females, all between the ages of 18 to 75, the test started
March 22 of this year 2021. It will wrap up June of 2022, the testing itself, and it's expected
that results will be out by August of 2022 this OTO-313 test is a parallel test. This means that there
are two different things that they are doing in this test, they're testing the OTO-313 injection
with a placebo, so it's parallel, the same thing, just a different medicine in each one. Scientists
utilize placebo, to eliminate the potential mental factor of tinnitus blending with the result.
If scientists find a significant decrease in those that actually receive the OTO-313 injection,
compared to those who had the placebo injection, they will know that tinnitus was certainly cured
by this injection. Now, if the placebo and OTO-313 have similar results, then there
will be speculation about the power of the mental side of things to overcome tinnitus. Regardless,
it's important to have these foundations and experiment, to be able to understand what is
working and why this OTO-313 test model is really interesting. It's a double blind test,
which means that the person receiving the treatment and the person giving the treatment
has no idea of what treatment this person is getting. Both OTO-313 And the placebo will be
administered in the same way through intratympanic injection. What this means is that a trained
professional will have a syringe and a needle, they will put that needle through the eardrum
of this participant and inject the serum, whether it's OTO-313, or the placebo, into the middle ear,
the inner ear will absorb the serum, and they will wait to see the results. Outcome measures for this
are very interesting, participants are supposed to keep a daily journal and keep a record of their
tinnitus events, for example, they will keep track of their change in daily tinnitus functional index
or TSI. They will essentially rate on a scale of zero to 100 how much their tinnitus interfered
or did not interfere with their day. Scientists are hoping that they'll see a strong correlation
between those that received OTO-313 and a reduction in tinnitus interfere with their day and hopefully
with a placebo, their results will stay similar if so that means out OTO-313 is making a difference.
In addition to that, participants will keep track of other things with regards to their tinnitus,
their triggers and what's going on, to be able to help researchers understand
whether or not OTO-313 is really reducing the tinnitus impact in people's lives.
Scientists will also be using audiometry or testing of the hearing a participant,
they will also be using otoscope examinations to understand how these injections affect the ear,
there are so many different ways to measure the success or failure of a medication in the FDA
drug trial process. These are several ways out OTO-313 will be measuring its success. So though
we will have to wait almost a year to hear about these results, it's great to know that there are
so many scientists across the nation, working on this project: scientists from California,
Colorado, Illinois, Kentucky, North and South Carolina, New York, Utah, Texas, Louisiana,
and more. This is quite a big undertaking. I'm really excited to see what happens, because a
cure for those with tinnitus specifically sensorineural tinnitus in this case would be incredible
and groundbreaking for hundreds of Americans and people across the world. What are your thoughts on
this cure for tinnitus? Do you have tinnitus? If so, would you be interested in trying out OTO-313
If it passes clinical trials? If so I would love to hear in the comments below. I have heard that
Tinnitus can be very debilitating. I've heard that it can interfere with the life and being able to
be stress free and things like that. If you struggle with tinnitus, remember that you are
not alone. There are so many people that struggle with tinnitus as well. In fact, about 25 million
Americans have tinnitus. Isn't that incredible 25 million of us can hear ringing in our ears
that others cannot hear. So just remember if you have tinnitus, you are not alone. And hopefully,
a cure will come soon. If you have any questions please let me know in the comments below. I look
forward to making more great content for you. Stay strong, stay amazing and have a great day.