Paris Ball-Miller have you worked with any people that are APOE4/4 oh yes I certainly have
effect of that genetic anchor on cardiovascular disease so a lot of people will say that APOE4/4
is more of a heritage and more of an inflammatory type of marker it was made more sense for
hunter-gatherers etc etc I think that's a lot of that's conjecture the bottom line is that APOE4
first of all what does APO mean APO is the protein itself apolipoprotein A is the protein component
of HDL apolipoprotein B is the protein component of LDL as well as IDL intermittent density liquid
proteins and VLDLs APOE is another family so you've got APOA APOB and LDLs APOC APOD
and then APOE is another protein and you can go and get some studies it used to be an expensive
genetic study now it's fairly simple fairly easily obtained from national labs like Quest the APOE
family has three major variations APO you do have APOE1 but it's not really significant the three
significant variations that you see are 2 3 and 4 I am 3/3 that's the most common
2 is fairly uncommon and 4 is fairly uncommon 4 is a little bit more inflammatory now if you
go back and you look the standard statement is well you can't have any fats if you're on
APOE4 well the reality is as you start digging deeper into that science I think the predominance
of that science would indicate that you know what it's probably more important to have a
minimal to moderate amount of ketosis going on on a regular basis if you're APOE4 than it is to
worry so much about fats now when I use the term ketosis does that mean that you have to be on a
ketotic a keto diet the answer is no the reality is you have ketosis ketones in your blood mostly
BHB beta-hydroxybutyrate if you're burning fats so if the majority of your calories are coming from
fats you're going to be having significant ketosis or ketone spill now you're not going to spill them
all day and in fact if you go in and you start looking at the ketone meters you're going to say
oh I'm not ketotic this is not ketotic this is a low level of expression of ketones bottom line is
what we used to think about APOE4 maybe not holding up in terms of the more recent science
but it's a great topic it's a very interesting thank you for bringing it up
why wait for a disease and hope for a cure I used to be an ER doc my name is Ford Brewer
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