"How Much Longer Do You Live on Statins?"
In response to the charge that describing the benefits of statin drugs
only in terms of relative risk reduction is a statistical deception created
to give the appearance that statins are more effective than they really are,
it was pointed out that the problem with describing things in terms
of absolute risk reduction, or "number needed to treat,"
is that they can depend on the duration of the study.
For example, say there's some disease that has a 2% chance of killing you
every year, but there's some drug that cuts your risk 50%.
That sounds amazing, but then you realize that at the end of the year,
your risk will only have fallen from 2% down to 1%,
so the absolute reduction of your risk is only 1%.
If 100 people were treated with the drug,
instead of two people dying, one person would die.
So you'd have to treat 100 people to save one life, so there's like a 99% chance
that taking the drug all year will have no effect on you either way.
So to say the drug cuts your risk of dying by 50%
seems like you're overstating things.
But think about it. The benefits accrue over time. If you have a 2% chance
of dying every year, year after year, after a few decades the majority
of those who refused the drug would be dead,
whereas the majority who took the drug would be alive.
So, yeah, maybe in the first year you took it there was only like a 1% chance
it would save your life, but eventually you could end up with a decent chance
the drug would save your life after all.
This is the very reason why using relative risk makes sense.
Absolute risk changes depending on what time frame you're talking about,
but with relative risk you know that whatever risk you have,
you can cut that risk in half taking the drug.
Now statins only cut your risk 25%, but since cardiovascular disease
is the number one killer of men and women,
if you're unwilling to change your diet, that's a powerful argument
in favor of these kinds of drugs. You can see the same kind of
dependency on trial duration looking at the "postponement of death" by statin use.
How much longer do you get to live if you take statins?
The average "postponement of death" has some advantages over other
statistics because it may offer a better intuitive understanding
among the general public,
whereas a stat like "number needed to treat"
has more of a win-or-lose lottery-like quality.
So when a statin drug prevents like one heart attack out of a 100 people treated
over five years, it's not like the other 99 completely lost out.
Their cholesterol dropped too, and their heart disease progression
also presumably slowed down, just not enough to catch a heart attack
within that narrow time frame.
So, what's the effect of statins on average survival?
According to an early estimate, if you put all the randomized trials together,
the " average postponement of death" was calculated
at maybe three or four days.
What? Who would take a drug every day for years just to live a few days longer?
Okay, well first let's try to put that in context.
Three or four days is actually comparable to the gains in life expectancy
from other medical interventions. For example, it's nearly identical
to what you'd get from highly effective childhood vaccines.
Because vaccines have been so effective in wiping out infectious diseases,
these days they only add an average of about three extra days to a child's life.
But of course, if your child is the rare life that gets saved,
they gain an entire lifetime. That's why we vaccinate.
It just seems like such a small average benefit because it gets distributed
over the many millions of kids who get the vaccine.
Is that the same with statins? An updated estimate was published
in 2019, which explained that the prior estimate of three or four days
was plagued by important weaknesses, and the actual average "postponement
of death" was actually 10 whole days.
Headline writers went giddy from these data, but what they didn't understand
is that this was only for the duration of the trial. So, if your life expectancy
is only five years, then yes, statins may only increase your lifespan
by 10 days, but statins are meant to be taken a lot longer than that.
What you want to know is how much longer you get to live
if you stick with the drugs your whole life, and in that case,
it's not living 10 extra days, but living up to 10 extra years.
Taking statins can enable you to live years longer. That's because
for every millimole per liter you drop your bad LDL cholesterol
you may live three years longer, maybe even six years longer
depending on which study you're reading. A millimole in US units is 39 points.
Drop your LDL cholesterol about 39 points and you could live years longer.
Exercise your whole life, and you may only increase
your lifespan by six months;
stopping smoking may net you nine months;
but drop your LDL cholesterol about 39 points and you could live years longer.
You can accomplish that by taking drugs or achieve that within just two weeks
of eating a diet packed with fruits, vegetables, and nuts.
Want to know what's better than drugs? Something important and fundamental
has been lost in the controversy about the broad expansion of statin therapy.
It is imperative that patients be informed by their physicians
and, hey, what about drug labels too,
that not only their cholesterol levels but also their cardiovascular risk
can be reduced substantially by adoption of a plant-based dietary pattern,
and without drugs. In fact, dietary modifications for cardiovascular
risk reduction, including plant-based diets,
have been shown to improve cholesterol status as well as
obesity, hypertension, systemic inflammation, and on and on.
The importance of this plant- based approach is magnified
when one considers that, in contrast to statins, the side effects---
weight loss, more energy, improved quality of life---are beneficial.