- Hello and welcome
to the Enterprise Fitness Education Series.
We've got the one and the only, Bob Guiel here.
In this video, we're gonna be talking about methylation.
Not a lot has really been explained I suppose
in an easy-to-understand way, methylation,
and we wanted to make this video to break it down
for the guys at home who may not be familiar
with the term methylation.
So Bob, very simply I'm gonna act dumb
and I know the next thing you're gonna say
is I don't have to act.
I'm gonna act dumb
and pretend I don't know anything about methylation.
So if we start from the beginning.
What is methylation and why is it important?
- Well, basically methylation is the process of by where
all chemical systems within your body,
particularly you transfer methyl groups
from one compound to another to make other compounds.
For instance, you convert amino acids into enzymes,
into proteins, okay?
And it's a very specific pathway
by using reducible gas into B12.
All right, with the amino acids like methionine.
Sounds simple, sounds basic,
but it takes place on the average
of about 4 billion times a minute in the human body, okay?
So it's one of the most important,
crucial biochemical pathways in the human body.
If we didn't methylate at all, we wouldn't live,
we wouldn't survive.
So when you look at that, and I know a lot of the training,
a lot of these guys went through,
you'll ask, "Well, what's methylation?"
And the instructor will say,
"Well, it's important for detox."
It's only one of the pathways it's important then, okay?
Without methylation now, there's about
almost 60 different methylation genetic snips
that are flaws now that they know of,
and they can relate to specific pathways.
And when you look at the variety of pathways involved
and how it can affect the human body,
let's just start with the very basic methylation pathways,
if you don't methylate correctly in certain pathways,
you don't make CoQ10,
you don't make glutathione, okay?
You don't make a carnitine.
You look at another end of the aspect of that,
you don't break down phenylalanine,
you don't make a dopamine, epinephrine, melatonin correctly.
You may not make serotonin correctly.
So there's your moods, anxieties, things like that.
- So you almost say that methylation is kind of like
the mother process in the body .
- Yeah, absolutely. - If that's off,
it's gonna really affect the whole system
from as you said, the liver,
and then when we look at things like carnitine pathways,
it's gonna affect the energy.
When we look at serotonin and dopamine pathways,
it's gonna affect people's moods,
anxiety, even maybe inducing depression
for some people who'd be mentally poor.
- Oh, most definitely, yes.
- Yeah, so this is where if you have people
who over methylate
and you can have also people who are under methylate.
- Right. - And let's say,
if you have someone who over methylates,
they're gonna push the glutamate pathway to heart,
and that would induce anxiety.
Is that all right?
- Yeah, that's one of the very, very likely potentials.
And those people keep putting out a methylate,
push that off and you'll see that you'll push that too hard,
and they'll tell you, they get anxious, they get wired.
Anxiety goes through the roof, they can't handle it,
they don't feel well.
You know, with those people...
Again, through the muscle testing, you can say,
"Okay, well, what we need to do with you,
is this, this and this."
And look at a series of single nutrients
that may help buffer that pathway for them.
- Because it might not just be the B9,
It might be the B12 or vice versa
- Or lithium, or phosphatidylserine, or even phenibut.
Maybe something...
It might be B6, niacin,
you don't know, that's why, as you noticed,
I don't go really big for the big formulations,
when I'm looking at things like this,
I look at single nutrients first,
bigger bang for less money.
- And the reason for that,
obviously you don't want to do big formulations is
because if it is, as you said,
if it's just, it's a B9 pathway
and the B12 pathway is already up regulated,
and it's doing it too well,
you give them more B12, it makes the problem worse.
- Yeah, you could potentially.
It's not the right balance for them.
- Yeah.
- You know and as we demonstrated in the classes
everybody's different balance.
I think the important thing to understand
with methylation too is,
and this is really kind of misunderstood,
is there are some doctors and some research looking at it,
but it hasn't hit the mainstream yet
because people don't understand it that well,
anything that can potentially be toxic to the human body,
whether you touch it, ingest it or breathe it in,
can interfere with methylation pathways.
We live in one of the most toxic worlds ever.
I read some research that said that,
you know, it's always been suspected
that maybe six to 10% of the population
was methylation deficient at some level.
Now the research is suggesting
it's as much as 60% of the population.
- Alright. - Okay.
- And if you combine that with the fact
that we've dumped over 85,000 toxic chemicals
in our environment,
half of which have been tested on adults,
none of which have been tested on children
that exacerbates the issue even further,
because now we have all these, you know, 85,000-
- Well, what even exacerbates even further is
now they know that the average child is born
with over 280 toxic chemicals already in its system
that day it's born.
- And that was done by the Environmental Working Group.
- Yes. - Back in 2002 (indistinct)
- Right, in conjunction with the American Red Cross, yeah.
- Yeah, which was fascinating to read
'cause they even found things like rocket fuel,
in the baby's umbilical cord.
So I mean, 200, I don't know if it's 85 or 87...
- Yeah 287 or something like that...
- Yeah, odd chemicals, foreign chemicals
found in babies umbilical cords as new born.
- So when you look at that and you look at the potential
for disrupting methylation pathways from day one,
it's a bigger problem than most people realize,
and the key thing is to understand
it doesn't just affect detox.
It can affect how you make digestive enzymes,
it can affect how your pancreas works,
it can affect dozens and dozens and dozens,
hundreds of pathways
- So if we look at kind of state-of-the-art testing,
I mean, I've been tested for methylation pathways,
via blood test for two snips.
And obviously there's over 60 snips, as you were saying.
One of...
I have one of the variants on a blood test
when we muscle tested me the other day,
said I'm a methylating machine, which is good for me.
But I mean, then you have the Asperger test as well people.
So I mean, there's a lot of different ways
to test for methylation.
In your opinion, what is the easiest, cheapest,
and best way to test for methylation?
- Muscle testing. - Right.
- And I'll tell you why,
you may have a snip, but is it heterozygous or homozygous?
Is it expressed itself?
At what rate are you not methylated?
Just because you have a snip,
doesn't mean, you know, there's different rates
because you had that snip, you know,
are you methylating still at 90, 95%,
are you Methylating only at 40%?
Obviously you're still functioning very well, okay?
Some people...
I had a client come in and had seven snips.
So everybody's affected differently.
Just like, I always say, you know,
we're not the same biochemically,
just because you had this snip
and you had this snip it doesn't mean
it's gonna affect yourself, your system's the same way.
- Another example that as you say that
with things like breast cancer, where people get tested
for the genetic markers of breast cancer.
And there's been cases where they come back
with all six variance to the genetic marker
to actually get breast cancer.
So they're very highly, high-risk group.
Then you have others who come in and they have
none of the genetic factors,
but yet they develop breast cancer.
Obviously there's more,
it's environment basically pulls the trigger
but the genetics load the gun.
- Yeah, exactly, and you said it,
you couldn't have said it said it more eloquently.
You can have a genetic factor.
When you look at holistically, how we maintain ourselves,
you have your genetics first,
and then you have your internal environment
and then the external environment,
and where they crash.
Where do they collide?
That's what throws off the balance.
So let's say you had two sets of twins,
they both have the same genetic marker.
This one either doesn't take care of themselves
and this one does,
this one's more likely to have a problem down the road
'cause they don't eat right,
they don't exercise, they don't take care of themselves.
Or if one gets an exposure to something
that the other one didn't,
then you're increasing the potential for that,
now that genetic factor to take hold
and cascade down the road.
- So what have you seen?
I mean, getting methylation right for someone
I mean what impact has that made in someone's life?
- I can honestly tell you that I've got a couple of clients
that came in to see me,
one is actually a nurse practitioner,
the only thing I did cause she didn't choose
a little leery of what we do.
I said, I'm just gonna put you on this
and I'm gonna put you on this methylation product,
come back and four weeks and tell me how you feel.
- So one supplement. - One supplement,
and yeah and that's it.
She couldn't believe, she can't stop raving
about how much it's turned her life around.
Now, not all results are that extreme,
but I can tell you that with...
Like I say, you know, in the BioSig world,
you learn it's important for detox
In my world, I see this important for mood enhancement,
for instamatic reduction, I've even got...
I have a client who, when she stops taking her methylator
her heartburn comes back.
So her gastro reflux comes back if she lets it slide.
So what does that tell you?
Is it potential that it plays a role in the feedback?
Possibly, because methylation doesn't just...
It's not just used to make things,
it's used for signaling mechanisms.
It regulates proteins
and protein function, regulates DNA expression,
a DNA signaling.
So its it's huge for a lot of factors in the human body.
- And I just wanna get one thing very clear
to the people at home is that we're not saying
that every single person needs to run out to the store
and buy Methyl-Guard Plus
and buy Methyl-Guard product or methylated product.
That's not what we're saying at all,
because potentially if you over methylate,
that's gonna cause harm as well.
The only real way to do it is to get himself muscle tested
you know, check if that's actually something
that is throwing off the balance of your body
and that you need.
Would you say that's a fair?
- Oh yeah, yeah,
I'm huge on not running out and buying something
'cause you heard it was good for you.
And there's some people who absolutely don't need it.
And not to mention the fact that,
there's different companies that make different formulas
with methylators in them,
and I have not seen one formula that everybody tests for.
So I have in my work or two,
I have about six different methylation formulas
from different companies
'cause everybody will test differently for it.
- Yeah, absolutely.
Well, I hope you've enjoyed this video.
I do thank you for watching,
make sure you subscribe to our channel on YouTube,
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check out the future list of course,
that we're gonna be running here at Enterprise Fitness
with the fabulous Bob Guiel.
Thanks for watching.