Okay anonymous attendee says B6 xanthurenate of 3.7 kynurenate of 1.4 both in the high
red end on the ION test taking 45 milligrams a day of B6 at time of test.
Increased B6 further too.
Anonymous can you put in the chat whether you're a woman, whether you know anything
about your estrogen levels, whether you are on oral contraceptives, and whether you are
menopausal or not.
If you hear me and you can put that in the chat anonymously that would be great, and
I'll come back to your question if you do answer that, and I'll move on for now.
Ah..man higher estrogen levels than normal.
Okay estrogen.
So estrogen regulates the, what estrogen does is it increases the conversion of tryptophan
to niacin, and my guess is that this is probably, or that this is probably "designed"
to increase niacin status in women especially when they might have the opportunity to get
pregnant or they actually get pregnant to keep up with the energy demands of pregnancy
and to support the niacin status of the baby.
But it just so happens that there's no clear way for your body to know if you're a man
and your estrogen levels are too high for a man or if you're a woman and you're on oral
contraceptives, it's just that that's what estrogen does.
So you probably want to look at ways to reduce estrogen, I'm, right now I'm extremely well-versed
in niacin and fairly well versed in tryptophan and very not well versed in estrogen.
So I don't know that I have a good explanation of what to do about estrogen.
Certainly alcohol is known to increase estrogen, I believe there are environmental toxins that
can increase estrogen, over weight will increase estrogen.
I'm not sure off the top of my head what other things are relevant in a man, but I would
definitely say that that's from the estrogen, especially if your plasma levels of pyridoxal
5’-phosphate are normal.
So I would follow it up with that test just to be sure, but it's almost certainly the
estrogen increasing those and they're just, there just isn't, there just isn't good data
on how to alter that in a way that, there isn't good, so in this is mostly studied in
women, and it's mostly studied in the context of oral contraceptives.
And in the context of oral contraceptives we know that oral contraceptives make these
markers go into the urine, but no one has really shown how to fix that.
So what I would do with the B6 is I would be very careful about whether there is anything
that responds to the B6.
So the first important thing is that if you have xanthurenate and kynurenate the main
risk of that actual fact of those spilling into your urine is actually that quinolinate
would be building up.
Quinolinate is usually the last thing to rise in B6 deficiency.
You didn't mention quinolinate being elevated and so quinolinate might not be elevated,
and you might not have problems.
But quinolinate is an excitotoxin: it both can cause neurotoxicity like glutamate does
and it can also make you hypersensitive to glutamate, so it can effectively make you
have glutamate sensitivity.
And I have one client where she had very high levels of estrogen, and she had very severe
insomnia, and 100 milligrams of pyridoxal 5’-phosphate, which is the active form of
B6, it was one of the first things that actually moved the needle in her sleep, but it only
lasted a couple weeks, then the effect started wearing off.
And so he clarifies that his quinolinate is in the fourth quintile.
Okay so you're kind of in the zone where you're like geez the quinolinate might be a problem,
particularly if you have trouble sleeping, or if you have trouble with anxiety, or you
have anything that you might, you know like, google “glutamate sensitivity,” headaches
and other stuff like that.
If you have any of those symptoms that could be from quinolinate buildup.
In that case I would, my first line of defense against this would be to increase B6, I would
titrate it up to 100 milligrams, you're already at a P5P of 45, so I wouldn't more than double
that.
And okay someone's asking how did anonymous attendee
insert dozens of questions ahead of mine?
I don't know I think that I'm going in order here, but there might be something wrong with
my order.
Unfortunately I don't want to, I don't want to disrupt the flow too much because I don't
want to run out of time on this and I think I can get to everyone, but oh orders... oh
people are upvoting, that's why, okay.
I think I'll get to everyone and so I just want to go through this straight and definitely
if it feels like we're going to run out of time I will start being more selective with
what I answer, but I want to finish this.
Okay so B6 marker spilling out into the urine.
Quinolinate is the primary concern because it's neurotoxic.
If there are any signs that you would associate with excessive glutamate then, then that's
where I would be concerned, I would go on symptoms, increasing the B6 100 milligrams,
I'd be very cautious going higher than that even on symptoms.
I probably wouldn't stretch that too much.
My second choice of action would be to lower the tryptophan content of the diet because
that's what's spilling over into the quinolinate.
Oh iron and riboflavin are also involved in that same pathway.
In theory, in theory these are B6 markers, but maybe in some people if iron or riboflavin
are particularly limiting and B6 isn't maybe these are indicating need for those nutrients.
Okay so first course of action is leveraged up the B6 to the optimum point where there's
no negative symptoms and you are getting a benefit from
higher doses managing symptoms.
Don't go up to higher doses if they're not helping managing symptoms.
Don't go over 100 milligrams of P5P.
Don't take any pyridoxine hydrochloride ever.
Second course of action is look at iron and B2 levels, if there's any things wrong with
those fix them.
Third course of action is if necessary reduce protein intake or search for low tryptophan
proteins and focus on those to meet your protein needs, providing that you don't go too low,
you're going to need at least a few hundred milligrams of tryptophan in your diet to be
okay, all of this is secondary to managing the estrogen which is probably the root cause
here.
All right.
Thank you for your question.