Welcome to this video tutorial on immunomodulators and immunosuppressive agents.
The body's immune system is a normally-occurring protective mechanism that helps the body defend
itself against potentially harmful agents.
However, sometimes the immune system perceives normally harmless substances,
such as allergens or the person's own body tissues,
as harmful invaders and tries to eliminate them.
This inappropriate activation of the immune response is a major factor in allergic and autoimmune disorders.
Let's start with some definitions.
Immunomodulators are natural or synthetic substances that modulate or modify the immune response.
They help regulate or normalize the immune system by either stimulating or suppressing the immune system.
Immunostimulants, such as vaccines and interferons, enhance the body's resistance against infections.
Immunosuppressive agents are drugs that suppress the immune system to reduce the risk of rejection
of foreign bodies with organ transplant or in autoimmune diseases.
Immunosuppressant drugs are used to decrease the immune response by interfering with the
production or function of immune cells and cytokines.
When foreign tissue or an organ is transplanted into the body,
the body has an appropriate but undesirable immune response.
If the immune response is not suppressed,
the body reacts by attempting to destroy the foreign tissue.
Immunosuppressant drugs are used to decrease this undesirable immune response
with transplants and autoimmune disorders.
Drug-induced immunosuppression is a major factor in tissue and organ transplantation.
There is a fine balance to adequate immunosuppression for the body to accept the transplant
without suppressing the immune system too much where the patient develops
serious infections and other adverse effects.
Immunosuppressant drugs are also given for autoimmune disorders
to decrease the undesirable immune response of the body.
Autoimmune disorders occur when a person's immune system attacks the healthy cells in the body by mistake.
The body has lost its ability to differentiate between antigens on its own cells
(self-antigens)
and antigens on foreign cells.
Generally, all autoimmune disorders share inflammation as a major mechanism of tissue damage.
There are many autoimmune diseases.
We'll take a look at a few common ones.
In multiple sclerosis (MS),
the immune system attacks nerve cells,
causing symptoms that can include muscle spasms, weakness,
poor coordination, pain, and blindness.
Rheumatoid arthritis occurs when the immune system produces antibodies that attach to the linings of joints,
which get attacked by immune system cells, causing inflammation, swelling, and pain.
In lupus (SLE), autoimmune antibodies attach to tissues throughout the body,
affecting the lungs, nerves, blood cells, joints, and kidneys.
Type 1 diabetes (mellitus) occurs when the immune system antibodies attack and destroy
insulin-producing cells in the pancreas.
Inflammatory bowel disease (IBD) occurs when the immune system attacks the lining of the intestines,
causing episodes of abdominal pain, diarrhea, urgent bowel movements, fever, and weight loss.
There are two forms of IBD: Crohn's disease and ulcerative colitis.
In psoriasis, overactive immune system T cells in the skin,
stimulating the skin cells to reproduce rapidly, forming scaly plaques on the skin.
In Myasthenia Gravis, antibodies bind to nerves and make them unable to stimulate muscles properly.
Seen as weakness that gets worse with activity.
Graves' disease occurs when the immune system produces antibodies that stimulate the thyroid
gland to release excess amounts of thyroid hormone,
causing hyperthyroidism.
Hashimoto's thyroiditus occurs when antibodies produced by the immune system
attack the thyroid gland,
slowly destroying the cells that produce thyroid hormone, leading to hypothyroidism.
Immunosuppressant drugs are diverse agents with often-overlapping mechanisms and sites of action.
Older drugs are generally non-specific and depress the entire immune response to all antigens,
greatly increasing the risk of serious infections and other side effects.
Immunosuppressants include corticosteroids,
cytotoxic antiproliferative agents, and conventional antirejection agents.
Corticosteroids are strong anti-inflammatory drugs that suppress the immune response at multiple levels.
They do have numerous side effects, so the duration of therapy should be as short as possible.
Examples include: Prednisone, dexamethasone,
hydrocortisone, betamethasone, and methylprednisolone.
Cytotoxic antiproliferative drugs damage or kill cells that are able to reproduce and
are primarily used in cancer chemotherapy.
However, in small doses some are also used to treat autoimmune disorders
and to prevent organ transplant rejection.
Examples include: Methotrexate and azathioprine.
Conventional antirejection agents include drugs such as cyclosporeine, tacrolimus, and sirolimus,
which are fungal metabolites with strong immunosuppressive effects
used to prevent rejection reactions after organ transplants.
Extensive research has been done to develop drugs with a more specific immunosuppressive action,
causing fewer or less severe adverse effects than older immunosuppressants.
They are often referred to as biologic response modifiers, or biologics.
Biologics are antibodies made from biological proteins, human or animal based,
that stop certain proteins in the body from causing inflammation.
Biological products include a wide range of products, such as blood and blood components,
vaccines, allergenics, gene therapy, and recombinant therapeutic proteins.
The biologics we will be discussing here are immunosuppressive drugs
that have had a profound impact on the treatment of many diseases,
which, in most cases, have had no effective therapies available.
Biologics target overactive cells in the body and are designed to block diseases in the
immune system, rather than waiting to treat the symptoms of the disease.
Biologic therapies offer a distinct advantage in treatment of diseases, because their mechanisms
of action are more precisely targeted to the factors responsible for the disease
instead of affecting the whole body as some immunosuppressants do.
Biologics are used to treat many autoimmune diseases.
However, their cost is significantly higher than other conventional medications.
Some of the newer biologic agents used for immunosuppression include:
Antibody preparations (which include polyclonal antibodies and monoclonal antibodies),
cytokine inhibitors (which include
and tumor necrosis factor - alpha blocking agents).
Antibody preparations are produced in the laboratory or derived from animals injected
with human lymphoid tissue to stimulate an immune response.
These drugs are used in inflammatory autoimmune disorders, transplant rejection reactions, and cancer
Monoclonal antibody drugs end in -mab, such as basiliximab and daclizumab.
Cytokine inhibitors are biologic agents that inhibit cytokines
that cause chronic inflammatory autoimmune disorders,
such as rheumatoid arthritis (RA), Crohn's disease, and psoriasis.
They suppress the inflammation and promote tissue repair.
However, they also increase the risks of serious infections, such as TB,
pneumococcal infections, necrotizing fasciitis, and others.
An example of an interleukin-blocking agent is anakinra (kineret) used to treat moderate to severe RA.
Some examples of TNF alpha-blocking agents include:
Adalimumab (Humira),
Infliximab (Remicade),
and Etanercept (Enbrel).
These drugs are used to treat autoimmune diseases such as RA, Crohn's disease,
ulcerative colitis, psoriasis, and psoriatic arthritis.
Other immunosuppressants used to treat RA include a biologic (abatacept, brand name Orencia),
leflunomide (Arava,
which is in a drug class called "disease-modifying antirheumatic drugs, or DMARDs).
This class of drugs can decrease joint damage and disability caused by RA.
The general side effects of all immunosuppressive agents include increased risk of infection and cancer.
Immunosuppressant drugs are used to treat serious illnesses, but thorough assessment
must be done to verify that the benefits outweigh the risks.
Let's go over some general patient teaching guidelines for patients taking immunosuppressant drugs.
Wash hands often and thoroughly and practice meticulous personal hygiene.
This applies to patients and others around the patient.
Avoid contact with infectious people.
To enhance immune defenses, practice healthy lifestyle habits,
such as a nutritious diet, adequate sleep, and avoiding tobacco and alcohol.
Keep a list of drugs taken, dosage, provider's information,
and emergency instructions with you in case of emergency.
Report adverse drug effects to a health care provider,
including signs and symptoms of infection,
such as sore throat or fever,
easy bruising or bleeding if taking methotrexate,
or decreased urine output if taking cyclosporine.
See the doctor regularly for evaluation of drug responses,
dosage changes, adverse drug reactions,
and blood monitoring tests that may be needed.
Notify the doctor if other drugs need to be taken.
Immunosuppressant drugs may interact with other medications,
decreasing therapeutic effects or increasing adverse effects.
Some vaccines should also be avoided while taking immunosuppressants.
Patients of reproductive age should practice effective contraception during immunosuppressive therapy
due to the adverse effects of some of the drugs on the fetus and mother.
Protect the skin from sunlight, as some drugs increase the risk of sensitivity to the sun,
sunburn, and skin cancer.
Thank you for watching this video tutorial on immunomodulators and immunosuppressive agents.
Be sure to check out our other videos.