For me these hard problems to be able to approach them with the intention of alleviating suffering
in a large patient population, and globally – the opportunity to create accessible,
safe and efficacious products to go after and train, to unlock the body’s immune system
and actually solve these problems ourselves is amazing.
So by turning the body into the drug factory (because it’s naturally producing these
endobodies), I think that’s a revolution in terms of the way we’re going to approach
chronic illness.
And so I’m pretty excited about that part.
So these are all vaccine based approaches.
What I like about vaccines is that if we can turn your body on to activate against something
that is an agent of pain that your body itself is generating, then you can have a very easy
way to take the product – it’s a single shot once a year, potentially.
So you have a great compliance rate with your patients, so it’s easy on your patient.
The cost is absolutely affordable and attainable.
So the cost becomes something that is accessible.
And you are in effect having a long duration of that treatment.
That’s going to give us the best chances to, in my opinion anyway, it’s going to
be one of the approaches that maximize our chances against the opioids and against the
epidemic that’s outstanding.
In addition to that we have some other things in our pipeline that are focused on the absorption
of opioids or the replacement of opioids from a pleasure perspective.
That’s earlier and so not really worth incorporating into what we’re doing here, but it would
be in like soon.
Those first two are big.
So, for example, we have an IL-6 vaccine that I’m really excited about.
And there are indications surrounding sciatica there that are really compelling.
And I think that that’s a huge need in terms of being able to remove that suffering and
that pain in a long-acting, affordable, and accessible way.
So that’s an example.
Another one is, there’s been a lot of noise around CGRP and monoclonal antibodies that
have been improved around that for migraine.
And we’ve got a vaccine for CGRP that we’re extremely excited about, and if you think
about the benefits of that it means that—one of the big problems with getting people to
take drugs is when they feel better they don’t want to take them.
But if your body is fighting that same target then you don’t have that same compliance
issue.
And so you actually make it easier for the patients to take the products that they’re
supposed to take in a timely manner and then maintain the benefits of those products.
So I think that’s going to be a really interesting product that we’re going to bring to market
and I think that’s a huge need.
And there’s a bunch of indications around that that are in the pipeline for the non-opioid
pain alternative, so it’s pretty exciting and it’s cool.
You have unbelievable rates of overdose happening in this country that are unprecedented.
And we have an opportunity to—some of that is driven by genuine need and pain.
And so some of those alternatives which are not particularly effective (and there’s
been more studies coming out around this over and over and over again) that I think we can
find more effective alternatives that are safer than opioids.
And I think that’s really one of the other focuses of United Neuroscience and something
that I’m personally passionate about, because the Alzheimer’s and the unintentional deaths
statistics are what are driving down our longevity for the first time in there consecutive years
since the Spanish flu.
So we should, morally, and we are, practically, focused on addressing those biggest possible
problems.
So it’s only consistent and it’s only right that we’re also dedicating some resource
and time and energy to addressing both the Alzheimer’s epidemic, the Parkinson’s
epidemic, and also the non-opioid pain epidemic.
When we look at this going forward, just to underline it I guess, these are diseases that
don’t discriminate.
I can’t articulate that enough.
These diseases don’t discriminate.
They don’t care how much money you have.
They don’t care where you live.
They don’t care what color your skin is.
And the bottom line is that our medicines can’t discriminate either.
And so our platform technology enables us to be accessible.
It enables us to actually go where the need is.
And for that I’m eternally optimistic.
So that’s pretty much it.